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(E/Z)-Capsaicin-d<sub>3</sub>

" in MedChemExpress (MCE) Product Catalog:

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8338

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

135

Biochemical Assay Reagents

142

Peptides

MCE Kits

Inhibitory Antibodies

706

Natural
Products

690

Recombinant Proteins

3829

Isotope-Labeled Compounds

227

Antibodies

117

Click Chemistry

226

Oligonucleotides

Targets Recommended: P-glycoprotein

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-U00050S

(E)-10-Hydroxynortriptyline-d3 E-10-OH-NT-d<sub>3sub>	Isotope-Labeled Compounds Drug Metabolite	Neurological Disease
(E)-10-Hydroxynortriptyline-d₃ is a deuterium labeled (E)-10-Hydroxy Nortriptyline. (E)-10-Hydroxy Nortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression .

HY-N0060BS

(E)-Ferulic acid-d3 (E)-Coniferic acid-d<sub>3sub>	β-catenin Bcl-2 Family Ferroptosis Endogenous Metabolite	Cancer
(E)-Ferulic acid-d₃ is the deuterium labeled (E)-Ferulic acid. (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299 .

HY-10448S

*(E/Z)-Capsaicin-d3*	Apoptosis Autophagy Endogenous Metabolite TRP Channel Isotope-Labeled Compounds	Others
(E/Z)-Capsaicin-d₃ is the deuterium labeled (E/Z)-Capsaicin[1].

HY-RS13999

SUB1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SUB1 Human Pre-designed siRNA Set A SUB1 Human Pre-designed siRNA Set A

HY-RS18793

Sub1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sub1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sub1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sub1 Mouse Pre-designed siRNA Set A Sub1 Mouse Pre-designed siRNA Set A

HY-RS25282

Sub1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sub1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sub1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sub1 Rat Pre-designed siRNA Set A Sub1 Rat Pre-designed siRNA Set A

HY-146227

DNA topoisomerase II inhibitor 1	Topoisomerase Apoptosis	Cancer
DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .

HY-114524S

(E)-4-Oxo-2-nonenal-d3 4-ONE-d<sub>3sub>	TRP Channel Isotope-Labeled Compounds	Others
(E)-4-Oxo-2-nonenal-d₃ is the deuterium labeled (E)-4-Oxo-2-nonenal .

HY-10448S1

Capsaicin-d3 (E)-Capsaicin-d<sub>3sub>	Isotope-Labeled Compounds TRP Channel Autophagy Apoptosis Endogenous Metabolite	Cancer
Capsaicin-d₃ is the deuterium labeled Capsaicin. Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects[1][2].

HY-W015084AS

(E)-β-Ionone-d3 β-Lonone-d<sub>3sub>	Apoptosis Isotope-Labeled Compounds	Cancer
(E)-β-Ionone-d₃ (β-Lonone-d₃) is deuterium-labeled (E)-β-Ionone (HY-W015084A) .

HY-10844S1

Pretomanid-d5 PA-824-d<sub>5sub>; (S)-PA 824-d<sub>5sub>	Antibiotic Bacterial Isotope-Labeled Compounds	Infection Cancer
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-P10215

Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2	Parasite	Infection
Ac-{Cpg}-Thr-Ala-{Ala(CO)}-Asp-{Cpg}-NH2 (compound 40) is a potent **Plasmodium subtilisin-like protease 1 (SUB1)** inhibitor. SUB1-IN-1 shows IC₅₀ values of 12 nM and 10 nM against P. vivax and P. falciparum SUB1 (Pv- and PfSUB1), respectively .

HY-B0234S

Estrone-13C3 E1-¹³C<sub>3sub>; Oestrone-¹³C<sub>3sub>	Isotope-Labeled Compounds Estrogen Receptor/ERR Endogenous Metabolite	Endocrinology Cancer
Estrone- ¹³C₃ is the ¹³C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells .

HY-N0367S

Trans-Anethole-d3 (E)-Anethole-d<sub>3sub>	Isotope-Labeled Compounds Endogenous Metabolite	Endocrinology
Trans-Anethole-d3 is deuterated labeled Trans-Anethole (HY-N0367). Trans-Anethole ((E)-Anethole) is an orally active phenylpropene derivative found in Foeniculum vulgare that is estrogenic at low concentrations and cytotoxic at high concentrations in tumor cell lines. Trans-Anethole also has anti-aflatoxin, anti-thrombotic and anti-diabetic activities. Trans-Anethole is an important odor component in plants such as fennel, myrtle, liquorice, and camphor ^[3] .

HY-10581AS

Gatifloxacin-d3 hydrochloride AM-1155-d<sub>3sub> hydrochloride; BMS-206584-d<sub>3sub> hydrochloride; PD135432-d<sub>3sub> hydrochloride	Isotope-Labeled Compounds Bacterial Topoisomerase Antibiotic	Infection
Gatifloxacin-d₃ (hydrochloride) is the deuterium labeled Gatifloxacin (hydrochloride). Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.

HY-N0683S1

2-ambo-Vitamin E-13C3 2-ambo-α-Tocopherol-¹³C<sub>3sub>	Isotope-Labeled Compounds Bacterial Influenza Virus Reactive Oxygen Species Ferroptosis Endogenous Metabolite	Infection Cancer
α-Vitamin E- ¹³C₃ is the ¹³C-labeled α-Vitamin E. α-Vitamin E ((+)-α-Tocopherol), a naturally occurring vitamin E form, is a potent antioxidant .

HY-16950BS

(E)-4-Hydroxytamoxifen-d5 (E)-Afimoxifene-d<sub>5sub>	Isotope-Labeled Compounds Estrogen Receptor/ERR	Cancer
(E)-4-Hydroxytamoxifen-d5 ((E)-Afimoxifene-d5) is the deuterium labeled (E)-4-Hydroxytamoxifen. (E)-4-Hydroxytamoxifen ((E)-Afimoxifene), the less active isomer of (Z)-4-hydroxytamoxifen, is an estrogen receptor modulator.

HY-Y0248AS

(E,E)-Farnesol-d6 trans,trans-Farnesol-d<sub>6sub>; (2E,6E)-Farnesol-d<sub>6sub>	Isotope-Labeled Compounds Endogenous Metabolite Bacterial Antibiotic	Infection Cancer
(E,E)-Farnesol-d₆ is deuterium labeled Farnesol. Farnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candida albicans, and has the activity in inhibiting bacteria.

HY-B0456S3

Riboflavin-d3 Vitamin B2-d<sub>3sub>; E101-d<sub>3sub>	Isotope-Labeled Compounds Endogenous Metabolite	Others
Riboflavin-d₃ is the deuterium labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.

HY-Y1311S

Malic acid-d3 Hydroxybutanedioic acid-d<sub>3sub>; E 296-d<sub>3sub>	Endogenous Metabolite	Others
Malic acid-d₃ is the deuterium labeled Malic acid. Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that is naturally found in fruits such as apples and pears. It plays a role in many sour or tart foods .

HY-B0131S2

Prostaglandin E1-d9 Alprostadil-d<sub>9sub>; PGE1-d<sub>9sub>	Isotope-Labeled Compounds Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Prostaglandin E1-d₉ is deuterium labeled Prostaglandin E1.Prostaglandin E1 is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inh

HY-Y1069S

(S)-Malic acid-d3 1 Publications Verification (S)-Hydroxybutanedioic acid-d<sub>3sub>; (S)-E 296-d<sub>3sub>; L-Malic acid-d<sub>3sub>	Endogenous Metabolite	Metabolic Disease
(S)-Malic acid-d₃ is the deuterium labeled (S)-Malic acid. (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form, contributes to the pleasantly sour taste of fruits and is used as a food additive .

HY-W700392

IMPDH-IN-2	IMPDH	Cancer
IMPDH-IN-2 (compound 2) is an inhibitor of inosine monophosphate dehydrogenase (IMPDH) with *IC_{50 for IMPDH I and IMPDH II >}*Values are 0.15 and 0.17 μM, respectively. IMPDH-IN-2 has antitumor activity .

HY-B1689AS

Methantheline-d3 bromide MTB 51-d<sub>3sub>; Mantheline-d<sub>3sub>; Metantyl-d<sub>3sub>; Metanyl-d<sub>3sub>; Metaxan-d<sub>3sub>; Methanide-d<sub>3sub>	Isotope-Labeled Compounds	Others
Methantheline-d₃ (bromide) is the deuterium labeled Methantheline bromide .

HY-101952S1

Prostaglandin E2-d9 PGE2-d<sub>9sub>; Dinoprostone-d<sub>9sub>	Isotope-Labeled Compounds Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Prostaglandin E2-d₉ is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation .

HY-101952S

Prostaglandin E2-d4 PGE2-d<sub>4sub>; Dinoprostone-d<sub>4sub>	Prostaglandin Receptor Endogenous Metabolite	Cardiovascular Disease Endocrinology
Prostaglandin E2-d₄ is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation .

HY-W067056S1

Methyl(E)-cinnamate-d7 Methyl(E)-3-phenylpropenoate-d<sub>7sub>	Isotope-Labeled Compounds	Inflammation/Immunology
Methyl(E)-cinnamate-d₇ is the deuterium labeled Methyl (E)-cinnamate . Methyl (E)-cinnamate (EMC), a phytochemical constituent isolated from Alpinia katsumadai Hayata, is a natural flavor compound with anti-inflammatory properties. Methyl (E)-cinnamate is widely used in the food and commodity industry .

HY-W067056S

Methyl (E)-cinnamate-d5 Methyl(E)-3-phenylpropenoate-d<sub>5sub>	Isotope-Labeled Compounds	Inflammation/Immunology
Methyl (E)-cinnamate-d₅ is the deuterium labeled Methyl (E)-cinnamate . Methyl (E)-cinnamate (EMC), a phytochemical constituent isolated from Alpinia katsumadai Hayata, is a natural flavor compound with anti-inflammatory properties. Methyl (E)-cinnamate is widely used in the food and commodity industry .

HY-10984S1

Pomalidomide-d3 CC-4047-d<sub>3sub>	Ligands for E3 Ligase Molecular Glues Apoptosis	Cancer
Pomalidomide-d₃ is the deuterium labeled Pomalidomide. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors .

HY-113465S

Leukotriene E4-d5 LTE4-d<sub>5sub>	Endogenous Metabolite	Inflammation/Immunology
Leukotriene E4-d₅ is the deuterium labeled Leukotriene E4. Leukotriene E4 (LTE4) is produced by the action of dipeptidase on LTD4. Leukotriene E4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A). Leukotriene E4 accumulates in both plasma and urine and urinary excretion of Leukotriene E4 is most often used as an indicator of asthma.

HY-113323S

3-Methoxy-4-hydroxyphenylglycol-d3 HMPG-d<sub>3sub>; MHPG-d<sub>3sub>; MOPEG-d<sub>3sub>	Endogenous Metabolite	Others
3-Methoxy-4-hydroxyphenylglycol-d₃ is the deuterium labeled 3-Methoxy-4-hydroxyphenylglycol.

HY-125833

Alpha-Naphthoflavone 5+ Cited Publications	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis	Cancer
Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis ^[3] .

HY-B1773AS5

Sodium Propionate-d3 Mycoban-d<sub>3sub>; Napropion-d<sub>3sub>; Ocuseptine-d<sub>3sub>	Isotope-Labeled Compounds	Others
Sodium Propionate-d₃ is the deuterium labeled Sodium Propionate .

HY-17413S

Zidovudine-d3 Azidothymidine-d<sub>3sub>; AZT-d<sub>3sub>; ZDV-d<sub>3sub>	Isotope-Labeled Compounds HIV	Infection Cancer
Zidovudine-d₃ is the deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection.

HY-B0621S

Triclabendazole-d3 CGA89317-d<sub>3sub>	Parasite Microtubule/Tubulin Isotope-Labeled Compounds	Others
Triclabendazole-d₃ is the deuterium labeled Triclabendazole (HY-B0621). Triclabendazole is an orally active parasite inhibitor. Triclabendazole has anti-Leishmania activity and induces gasdermin E (GSDME)-dependent pyroptosis by caspase-3 activation. Triclabendazole can be used for the research of fasciola hepatica ^[3].

HY-W018811

Antibacterial agent 268	Bacterial	Infection
Antibacterial agent 268 (Compound 10e) is an antibacterial agent with antimycobacterial properties. Antibacterial agent 268 shows high anti-bacterial properties at sub-micromolar values (MIC=0.44-0.07 μM) .

HY-W392083S

(1,3E,5E)-Undeca-1,3,5-triene-d5 (1,3E,5E)-UNDECATRIENE-d<sub>5sub>	Isotope-Labeled Compounds	Others
(1,3E,5E)-Undeca-1,3,5-triene-d₅ is deuterated labeled (1,3E,5E)-Undeca-1,3,5-triene.

HY-B0715S3

Pentoxifylline-d3 BL-191-d<sub>3sub>; PTX-d<sub>3sub>; Oxpentifylline-d<sub>3sub>	Isotope-Labeled Compounds Autophagy Phosphodiesterase (PDE) HIV	Cardiovascular Disease Cancer
Pentoxifylline-d₃ (BL-191-d₃) is deuterium labeled Pentoxifylline. Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation ^[3].

HY-B0607S

Nitisinone-d3 NTBC-d<sub>3sub>; Nitisone-d<sub>3sub>; SC0735-d<sub>3sub>	Isotope-Labeled Compounds HPPD	Metabolic Disease
Nitisinone-d₃ (NTBC-d₃) is deuterium labeled Nitisinone. Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC₅₀ of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism ^[3] .

HY-N0683S6

α-Vitamin E-d11 (+)-α-Tocopherol-d<sub>11sub>; D-α-Tocopherol-d<sub>11sub>	Isotope-Labeled Compounds Bacterial Ferroptosis Reactive Oxygen Species Influenza Virus Endogenous Metabolite	Infection Cancer
α-Vitamin E-d11 ((+)-α-Tocopherol-d11) is the deuterium labeled α-Vitamin E (HY-N0683). α-Vitamin E ((+)-α-Tocopherol), a naturally occurring vitamin E form, is a potent antioxidant .

HY-B0497S2

Niclosamide-d3 BAY2353-d<sub>3sub>	Isotope-Labeled Compounds Antibiotic STAT Parasite	Infection Cancer
Niclosamide-d₃ (BAY2353-d₃) is deuterium labeled Niclosamide. Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research . Niclosamide is a *STAT3* inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells ^[3] .

HY-70002S

Deutenzalutamide Enzalutamide-d<sub>3sub>; MDV3100-d<sub>3sub>	Androgen Receptor Autophagy	Cancer
Deutenzalutamide (Enzalutamide-d₃) is a developed deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells .

HY-134928AS

Pyridinium bisretinoid A2E-d4 TFA A2E-d<sub>4sub> TFA	Isotope-Labeled Compounds	Cancer
Pyridinium bisretinoid A2E-d₄ TFA is the deuterium-labeled Pyridinium bisretinoid A2E (HY-134928). Pyridinium bisretinoid A2E (A2E)is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species ^[3] .

HY-W008794S

Normetanephrine-d3 hydrochloride (±)-Normetanephrine-d<sub>3sub> hydrochloride; DL-Normetanephrine-d<sub>3sub> hydrochloride; (Rac)-Normetanephrine-d<sub>3sub> hydrochloride	Endogenous Metabolite	Metabolic Disease
Normetanephrine-d₃ (hydrochloride) is the deuterium labeled Normetanephrine hydrochloride. Normetanephrine ((±)-Normetanephrine) hydrochloride is the O-methylated metabolite of norepinephrine (NE) .

HY-B0457AS

Clomipramine-d3 Chlorimipramine-d<sub>3sub>; G-34586-d<sub>3sub>; NSC-169865-d<sub>3sub>	Isotope-Labeled Compounds Serotonin Transporter Dopamine Receptor	Neurological Disease
Clomipramine-d₃ is the deuterium labeled Clomipramine. Clomipramine is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with K_i of 0.14, 54 and 3 nM, respectively .

HY-66005S1

Acetaminophen-d3 Paracetamol-d<sub>3sub>; 4-Acetamidophenol-d<sub>3sub>; 4'-Hydroxyacetanilide-d<sub>3sub>	COX Histone Acetyltransferase Endogenous Metabolite	Inflammation/Immunology
Acetaminophen-d₃ is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent ^[3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-B0141AS

Alpha-Estradiol-d3 Alfatradiol-d<sub>3sub>; Epiestradiol-d<sub>3sub>; Epiestrol-d<sub>3sub>	5 alpha Reductase Endogenous Metabolite	Inflammation/Immunology
Alpha-Estradiol-d₃ is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.

HY-N0176S

Dihydroartemisinin-d3 Dihydroqinghaosu-d<sub>3sub>; β-Dihydroartemisinin-d<sub>3sub>; Artenimol-d<sub>3sub>	Parasite NF-κB Autophagy Apoptosis	Infection Cancer
Dihydroartemisinin-d₃ is the deuterium labeled Dihydroartemisinin. Dihydroartemisinin is a potent anti-malaria agent.

HY-13756S2

Tacrolimus-d3 FK506-d<sub>3sub>; Fujimycin-d<sub>3sub>; FR900506-d<sub>3sub>	Isotope-Labeled Compounds Autophagy FKBP Bacterial Antibiotic Phosphatase	Infection Inflammation/Immunology Cancer
Tacrolimus-d₃ (FK506-d₃) is deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

HY-30151S

Methoxsalen-d3 8-Methoxypsoralen-d<sub>3sub>; Xanthotoxin-d<sub>3sub>; 8-MOP-d<sub>3sub>	Cytochrome P450	Inflammation/Immunology
Methoxsalen-d₃ is the deuterium labeled Methoxsalen[1]. Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight[2].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-125833

Alpha-Naphthoflavone 5+ Cited Publications	Flavonoids Flavones Source classification Indigofera heterantha Wall. ex Brand. Plants Compositae Disease Research Fields Cancer	Cytochrome P450 Aryl Hydrocarbon Receptor Apoptosis
Alpha-Naphthoflavone is an orally active flavonoid that is a potent, competitive inhibitor of aromatase< b>aromatase. < b > IC < sub > 50 < / sub > < / b > and < b > K < sub > I < / sub > < / b > value were 0.5 and 0.2 microns. Alpha-Naphthoflavone can inhibit cell proliferation and induce apoptosis ^[3] .

HY-B0504S

Creatinine-d3 4 Publications Verification NSC13123-d<sub>3sub>	Classification of Application Fields Metabolic Disease Disease Research Fields	Isotope-Labeled Compounds Endogenous Metabolite
Creatinine-d₃ is a deuterium labeled Creatinine. Creatinine is a break-down product of creatine phosphate in muscle .

HY-W011474

Geranylgeraniol	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model ^[3] .

HY-P2274

Argifin	Infection Structural Classification Natural Products Microorganisms Classification of Application Fields Source classification Disease Research Fields	Parasite
Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC₅₀s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively .

HY-W011474R

Geranylgeraniol (Standard)	Structural Classification Natural Products Microorganisms	NF-κB
Geranylgeraniol (Standard) is the analytical standard of Geranylgeraniol. This product is intended for research and analytical applications. Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model ^[3][4].

HY-N0662

Amentoflavone 5+ Cited Publications Didemethyl-ginkgetin	Structural Classification Flavonoids Classification of Application Fields Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Cancer	Reactive Oxygen Species Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase ^[3] .

HY-N0007

(E,E)-Bisdemethoxycurcumin 4 Publications Verification (E,E)-Curcumin III; (E,E)-Didemethoxycurcumin	Zingiber officinale Roscoe Structural Classification Classification of Application Fields Source classification Phenols Polyphenols Plants Disease Research Fields Zingiberaceae Cancer	Apoptosis Autophagy
(E,E)-Bisdemethoxycurcumin ((E,E)-Curcumin III) is a curcumin derivative with anti-inflammatory and anticancer activities ^[3] .

HY-N11799

Neochilenin 3-O-Methylquercetin 4′-O-glucoside	Structural Classification Flavonoids Source classification Plants Compositae Other Flavonoids	Others
Neochilenin (3-O-Methylquercetin 4 '-O-glucoside) is a glycoside of 3-O-methylquercetin, which can be isolated from the sub-family Cereoideae (Cactaceae). .

HY-N15356

9-Oxooctadecanedioic acid	Structural Classification Ketones, Aldehydes, Acids Source classification Plants Quercus suber L. Fagaceae	Bacterial
9-Oxooctadecanedioic acid is an α,ω-dicarboxylic fatty acid monomer found in the cork suberin of Quercus suber. It contributes to the formation of the hydrophobic barrier structure in plant cell walls and may play an important role in functions such as water resistance and protection against microbial penetration .

HY-N10192

Aculene D	Infection Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Source classification Disease Research Fields	Endogenous Metabolite Bacterial
Aculene D, a fungal metabolite, shows quorum sensing (QS) inhibitory activity against Chromobacterium violaceum CV026, and could significantly reduce violacein production in N-hexanoyl-l-homoserine lactone (C6-HSL) induced C. violaceum CV026 cultures at sub-inhibitory concentrations .

HY-W011370

Pelargonidin chloride	Structural Classification Anthocyans Flavonoids Classification of Application Fields Leguminosae Source classification Other Diseases Phenols Polyphenols Plants Phaseolus vulgaris Linn. Disease Research Fields	Reactive Oxygen Species
Pelargonidin chloride is an anthocyanidin and also is a scavenger of nitric oxide radical and has antioxidant activities. Pelargonidin inhibits cell viability and induces cell cycle arrest at sub-G1 phase. Pelargonidin chloride increases the mRNA and protein expression of HO-1, NQO1, Nrf2. Pelargonidin chloride improves Aβ-induced memory and learning impairment ^[3].

HY-N15496

Fusaproliferin FUS	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source classification	Reactive Oxygen Species NO Synthase Interleukin Related TNF Receptor p38 MAPK ERK IKK NF-κB
Fusaproliferin is a sesterterpene mycotoxin isolated from Fusarium solani. Fusaproliferin reverse Lipopolysaccharides (HY-D1056) stimulation and the NF-κB and MAPKs signaling pathways contribute to the anti-inflammatory process. Fusaproliferin exhibits affinity for the TLR4 protein with K_D values of 28.6 μM. Fusaproliferin shows cytotoxicity against pancreatic cancer cell with rapid and sub-micromolar IC₅₀ .

HY-P2274R

Argifin (Standard)	Structural Classification Natural Products Microorganisms Source classification	Parasite
Argifin (Standard) is the analytical standard of Argifin. This product is intended for research and analytical applications. Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC50s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively[1].

HY-N0007R

(E,E)-Bisdemethoxycurcumin (Standard)	Zingiber officinale Roscoe Structural Classification Source classification Phenols Polyphenols Plants Zingiberaceae	Apoptosis Autophagy
(E,E)-Bisdemethoxycurcumin (Standard) is the analytical standard of (E,E)-Bisdemethoxycurcumin. This product is intended for research and analytical applications. (E,E)-Bisdemethoxycurcumin ((E,E)-Curcumin III) is a curcumin derivative with anti-inflammatory and anticancer activities ^[3] .

HY-N0662R

Amentoflavone (Standard)	Structural Classification Flavonoids Source classification Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring	Reactive Oxygen Species Apoptosis Bacterial Fungal RSV GABA Receptor
Amentoflavone (Standard) is the analytical standard of Amentoflavone. This product is intended for research and analytical applications. Amentoflavone (Didemethyl-ginkgetin) is a potent and orally active GABA(A) negative modulator. Amentoflavone also shows anti-inflammatory, antioxidative, anti-viral, anti-tumor, anti-radiation, anti-fungal, antibacterial activity. Amentoflavone induces apoptosis and cell cycle arrest at sub-G1 phase ^[3] .

HY-N12873

(E,E,E,)-10,12,14-Hexadecatrienal	Structural Classification Natural Products Animals Source classification	Others
(E,E,E,)-10,12,14-Hexadecatrienal is a pheromone that can be produced by female Manduca sexta .

HY-N0359A

(E)-Cynarin (E)-Cynarine; (E)-Plemocil	Structural Classification Source classification Phenols Polyphenols Cynara scolymus L. Plants Compositae	Reactive Oxygen Species
(E)-Cynarin ((E)-Cynarine) is the E-isomer of Cynarin (HY-N0359). Cynarin is an anti-asphyxiant with multiple biological activities, possessing antioxidant, antihistamine, and antiviral activities, etc.

HY-N12902

(E)-9-Hexadecenyl acetate (E)-9-HDA	Structural Classification Natural Products Animals Source classification	Others
(E)-9-Hexadecenyl acetate ((E)-9-HDA) is an insect pheromone that can be isolated from Elasmopalpus lignosellus .

HY-N1378

(E)-Cardamonin 1 Publications Verification (E)-Cardamomin; (E)-Alpinetin chalcone	Structural Classification Alpinia katsumadai Hayata Neurological Disease Classification of Application Fields Source classification Plants Chalcones Flavonoids Phenols Polyphenols Disease Research Fields Zingiberaceae Cancer	TRP Channel Apoptosis
(E)-Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC₅₀ of 454 nM.

HY-N1214A

(E/Z)-Squalene (E/Z)-Super Squalene; (E/Z)-AddaVax	Structural Classification Natural Products Animals Source classification	Apoptosis
(E/Z)-Squalene ((E/Z)-Super Squalene; (E/Z)-AddaVax) is a triterpenic compound. (E/Z)-Squalene accumulates and reduces liver cholesterol and triglycerides in the liver. (E/Z)-Squalen regulates the production of intracellular active oxidants (ROS) and induces apoptosis and necrosis in a concentration-and time-dependent manner .

HY-N10751

(2E,4E)-Decadienoic acid	Structural Classification Ketones, Aldehydes, Acids Source classification Piperaceae Plants Piper nigrum Linn.	Bacterial
(2E,4E)-Decadienoic acid is an anti-oomycete aliphatic compound that can be found in Coculture of Bacillus subtilis and Trichoderma asperellum .

HY-N5097

13-Oxo-9E,11E-octadecadienoic acid	Natural Products other families Classification of Application Fields Source classification Metabolic Disease Plants Disease Research Fields	PPAR
13-Oxo-9E,11E-octadecadienoic acid, an isomer of 9-oxo-ODA, is a potent PPARα activator derived from tomato juice. 13-Oxo-9E,11E-octadecadienoic acid decreases plasma and hepatic triglyceride in obese diabetic mice .

HY-W230975

(E/Z)-Piperine (E/Z)-Bioperine; (E/Z)-1-Piperoylpiperidine	Structural Classification Alkaloids Piperidine Alkaloids Source classification Piperaceae Plants Piper nigrum Linn.	Cytochrome P450 P-glycoprotein
(E/Z)-Piperine ((E/Z)-Bioperine) is an alkaloid with a pungent property. (E/Z)-Piperine shows anti-inflammation, immunomodulatory and anti-cancer, antispasmodic and anti-secretory effects. (E/Z)-Piperine demonstrates significant neuroprotective effect in Alzheimer’s disease and Parkinson’s disease .

HY-W742595

(E,E)-10,12-Hexadecadienol	Structural Classification Natural Products Animals Source classification	Sex Pheromone
(E,E)-10,12-Hexadecadienol is a female pheromone isolated from legume pod borer .

HY-W701835

(E,E)-10,12-Hexadecadienal	Structural Classification Natural Products Animals Source classification	Sex Pheromone
(E,E)-10,12-Hexadecadienal is a female pheromone isolated from female Earias insulana .

HY-N15223

[(2E,4E)-Octadienoyl]-N-isobutylamide	Structural Classification Natural Products Source classification Piperaceae Plants Piper nigrum Linn.	Endogenous Metabolite
[(2E,4E)-Octadienoyl]-N-isobutylamide (compound 2) is an isobutylamide that can be isolated from pepper seeds .

HY-N14448

11-Keto-9(E),12(E)-octadecadienoic acid	Structural Classification Natural Products Microorganisms Source classification	Others
11-Keto-9(E),12(E)-octadecadienoic acid has enhanced endothelial cell fibrinolytic activity .

HY-W709856

Dodeca-2E,4E,8Z,10Z/E-N-tetraenoic acid isobutylamide	Structural Classification Alkaloids Other Alkaloids Source classification Plants Compositae Echinacea angustifolia DC.	Influenza Virus
Dodeca-2E,4E,8Z,10Z/E-N-tetraenoic acid isobutylamide is a brain-penetrant substance and the main alkamide in Echinacea preparations, which might be used for research of common cold and various upper respiratory infections .

HY-N12922

(E,E)-8,10-dodecadienyl acetate	Structural Classification Natural Products Animals Source classification	Others
(E,E)-8,10-dodecadienyl acetate is isolated from attractants of pine shoot moths (Rhyacionia rigidana) .

HY-59097

(E/Z)-Tapinarof (E/Z)-WBI-1001; (E/Z)-Benvitimod; (E/Z)-GSK2894512	Structural Classification Microorganisms Antibiotics Source classification Phenols Polyphenols	Antibiotic Bacterial Fungal
(E/Z)-Tapinarof ((E/Z)-WBI-1001; 3,5-dihydroxy-4-isopropylstilbene) is a broad-spectrum antibiotic. (E/Z)-Tapinarof has anti-bacterial, anti-fungal and anti-nematode activities .

HY-W018643A

(E)-Ferulic acid methyl ester Methyl (E)-ferulate	Structural Classification Monophenols Ginkgoaceae Classification of Application Fields Simple Phenylpropanols Source classification Other Diseases Phenols Phenylpropanoids Plants Ginkgo biloba Disease Research Fields	COX
(E)-Ferulic acid methyl ester (Methyl (E)-ferulate) exhibits strong DPPH and ABTS ⁺ radical scavenging activities .

HY-N0060B

(E)-Ferulic acid (E)-Coniferic acid	Structural Classification Classification of Application Fields Source classification Plants Endogenous metabolite Human Gut Microbiota Metabolites Monophenols Microorganisms other families Simple Phenylpropanols Phenols Phenylpropanoids Disease Research Fields Cancer	β-catenin Bcl-2 Family Ferroptosis Endogenous Metabolite
(E)-Ferulic acid is an isomer of ferulic acid, an aromatic compound abundant in plant cell walls. (E)-Ferulic acid causes phosphorylation of β-catenin (β-catenin), leading to proteasome degradation, increasing the expression of pro-apoptotic factor Bax and reducing pro-apoptotic factor Expression of the survival factor survivin. (E)-Ferulic acid can effectively remove reactive oxygen species (ROS) and inhibit lipid peroxidation. (E)-Ferulic acid exerts antiproliferative and antimigratory effects in the human lung cancer cell line H1299.

HY-W012952R

(2E,4E)-Hepta-2,4-dienal (Standard)	Structural Classification Natural Products Vaccinium macrocarpon Aiton Source classification Ericaceae Plants	Biochemical Assay Reagents
(2E,4E)-Hepta-2,4-dienal (Standard) is the analytical standard of (2E,4E)-Hepta-2,4-dienal. This product is intended for research and analytical applications. (2E,4E)-Hepta-2,4-dienal is a naturally occurring organic compound that belongs to the group of aldehydes. It is an unsaturated aldehyde with two conjugated double bonds, giving it unique chemical and physical properties. (2E,4E)-Hepta-2,4-dienal is commonly found in various plant sources, especially in spices such as parsley and coriander. It is used as a flavoring agent and food additive in the formulation of various foods such as baked goods, snacks and beverages. It is also used in the fragrance industry, especially in the production of perfume and cologne.

HY-N3149

(E)-2-Hydroxycinnamaldehyde	Structural Classification Monophenols Cinnamomum cassia (L.) D. Don Source classification Phenols Plants Lauraceae	STAT Apoptosis Reactive Oxygen Species
(E)-2-Hydroxycinnamaldehyde is an aldehyde that can be separated from the stem bark of cinnamon. (E)-2-Hydroxycinnamaldehyde inhibits cell proliferation and induces apoptosis by inhibiting signal transduction of *STAT3* and reactive oxygen species production. (E)-2-Hydroxycinnamaldehyde has antitumor activity .

HY-N0120

(E/Z)-Polydatin (E/Z)-Piceid	Structural Classification Stilbenes Classification of Application Fields Polygonaceae Reynoutria japonica Houtt. Source classification Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields	Others
(E/Z)-Polydatin ((E/Z)-Piceid) is the E/Z mixture of Polydatin (HY-N0120A). Polydatin is a monocrystalline compound originally isolated from the root and rhizome of Polygonum cuspidatum. (E/Z)-Polydatin has anti-platelet aggregation, anti-oxidative action of low-density lipoprotein (LDL), cardioprotective activity, anti-inflammatory and immune-regulating functions .

HY-N7781R

(-)-(E)-Guggulsterone (Standard) (E)-Guggulsterone (Standard)	Structural Classification Classification of Application Fields Commiphora myrrha (Nees) Engl. Source classification Metabolic Disease Plants Burseraceae Disease Research Fields Steroids	Drug Metabolite
(-)-(E)-Guggulsterone (Standard) is the analytical standard of (-)-(E)-Guggulsterone. This product is intended for research and analytical applications. (-)-(E)-Guggulsterone is the metabolite of Z-guggulsterone. Guggulsterone is an active constituent of guggulipid, an ayurvedic agent derived from Commiphora mukul. Guggulsterone has hypolipidaemic activity .

HY-W753500

(E,E)-9,11-Tetradecadienyl acetate	Structural Classification Natural Products Animals Source classification	Others
(E,E)-9,11-Tetradecadienyl acetate is a female sex pheromone isolated from light-induced isomerization products in female coastal noctuid moths .

HY-N1378R

(E)-Cardamonin (Standard)	Structural Classification Chalcones Flavonoids Alpinia katsumadai Hayata Source classification Phenols Polyphenols Plants Zingiberaceae	TRP Channel Apoptosis
(E)-Cardamonin (Standard) is the analytical standard of (E)-Cardamonin. This product is intended for research and analytical applications. (E)-Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM.

HY-N7047

8-Epidiosbulbin E acetate 8-Epidiosbulbin E acetate	Infection Structural Classification Natural Products Classification of Application Fields Verbenaceae Source classification Plants Disease Research Fields Premna cavaleriei Levl.	Bacterial
8-Epidiosbulbin E acetate, a furanoid, is abundant in Dioscorea bulbifera L.. 8-Epidiosbulbin E acetate exhibits broad-spectrum plasmid-curing activity against multidrug-resistant (MDR) bacteria. 8-Epidiosbulbin E acetate induces liver injury in mice .

HY-N12191

Cangorinine E-1	Structural Classification Alkaloids Terpenoids Other Alkaloids Sesquiterpenes Source classification Celastraceae Plants Tripterygium wilfordii Hook. f.	HSV
Cangorinine E-1 (compound 11) is a dihydroagarofuran derivative of the sesquiterpenoid family. Cangorinine E-1 exhibits weak inhibitory effects on herpes simplex virus type II (HSV) .

HY-N14398

Sannamycin E	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Bacterial
Sannamycin E is an aminoglycoside antibiotic. Sannamycin E can be found in Streptomyces sannanensis KC-7038. Sannamycin E has weak antibacterial activity against Gram-positive bacteria .

HY-N9983

Effusanin E	Labiatae Artemisia dracunculus L. Plants	Others
Effusanin E is a diterpenoid. Effusanin E, a 7α, 20-Epoxy-ent-kauranoid, can be obtained from Isodon parvifolius. Effusanin E can be used for the research of cancer .

HY-N14887

Phleomycin E	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial
Phleomycin E is a heteropeptide antibiotic. Phleomycin E has anti-Gram-positive bacteria, negative bacteria and mycobacterium effects. Phleomycin E extends the survival time of mice transplanted with Ehrman's ascites cancer. Phleomycin E inhibits airy entity carcinoma in mice with an IC₅₀ of 0.31 μg/mL .

HY-N9376

Kansuinine E	Structural Classification Classification of Application Fields Terpenoids Source classification Euphorbia kansui T. N. Liou ex S. B. Ho Diterpenoids Euphorbiaceae Plants Inflammation/Immunology Disease Research Fields	NO Synthase
Kansuinine E is a plant-derived nitric oxide inhibitor (IC₅₀=6.3 μM). Kansuinine E belongs to jatrophane-type diterpenoids and is isolated from the roots of E. kansui .

HY-N9768

(10E,12E)-9-Oxo-10,12-octadecadienoic acid 9-oxo-ODA	Structural Classification Microorganisms Ketones, Aldehydes, Acids Source classification	Fungal PPAR
(10E,12E)-9-Oxo-10,12-octadecadienoic acid (9-oxo-ODA) is a PPARα agonist that can be isolated from the basidiomycete Gomphus floccosus. (10E,12E)-9-Oxo-10,12-octadecadienoic acid enhances fatty acid oxidation through PPARα activation, thereby inhibiting triglyceride accumulation. (10E,12E)-9-Oxo-10,12-octadecadienoic acid also has antifungal (Fungal) activity .

HY-N2809

Acantrifoside E	Structural Classification Natural Products Salacia cochinchinensis Lour. Source classification Celastraceae Plants	Others
Acantrifoside E (Compound 8) is a nature compound. Acantrifoside E can be isolated from the 90% ethanol extract of Salacia cochinchinensis. Acantrifoside E has none α-glucosidase inhibitory activity .

HY-133220

Guajadial E	Structural Classification Source classification Psidium guajava Linn. Phenols Polyphenols Myrtaceae Plants	Others
Guajadial E is a natural product that can be found in Psidium guajava. Guajadial E shows cytotoxicity .

HY-N14826

Nanaomycin E	Structural Classification Microorganisms Antibiotics Source classification Other Antibiotics	Antibiotic Bacterial Fungal
Nanaomycin E is an antibiotic. Nanaomycin E has activity against Gram-positive bacteria and fungi .

HY-N12874

(E,E,Z)-10,12,14-Hexadecatrienal	Structural Classification Natural Products Animals Source classification	Others
(E,E,Z)-10,12,14-Hexadecatrienal is a pheromone that can be produced by female Manduca sexta .

HY-N12921

(E)-8-Dodecenol	Structural Classification Natural Products Animals Source classification	Others
(E)-8-Dodecenol is a pheromone that increases the frequency of electro-pulse spikes in mid-receptor neurons of codling moth (Cydia pomonella L.). (E)-8-Dodecenol is isolated from female codling moths .

Cat. No.	Product Name	Chemical Structure

HY-U00050S

(E)-10-Hydroxynortriptyline-d3
(E)-10-Hydroxynortriptyline-d₃ is a deuterium labeled (E)-10-Hydroxy Nortriptyline. (E)-10-Hydroxy Nortriptyline is a metabolite of Nortriptyline. Nortriptyline is a tricyclic antidepressant and the main active metabolite of Amitriptyline, and is used to relieve the symptoms of depression .

HY-N0060BS

(E)-Ferulic acid-d3

(E)-Ferulic acid-d₃ is the deuterium labeled (E)-Ferulic acid. (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299 .

HY-B0234S

Estrone-13C3
Estrone- ¹³C₃ is the ¹³C-labeled Estrone. Estrone (E1) is a natural estrogenic hormone. Estrone is the main representative of the endogenous estrogens and is produced by several tissues, especially adipose tissue. Estrone is the result of the process of aromatization of androstenedione that occurs in fat cells .

HY-10448S

*(E/Z)-Capsaicin-d3*
(E/Z)-Capsaicin-d₃ is the deuterium labeled (E/Z)-Capsaicin[1].

HY-114524S

(E)-4-Oxo-2-nonenal-d3
(E)-4-Oxo-2-nonenal-d₃ is the deuterium labeled (E)-4-Oxo-2-nonenal .

HY-10448S1

Capsaicin-d3
Capsaicin-d₃ is the deuterium labeled Capsaicin. Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects[1][2].

HY-W015084AS

(E)-β-Ionone-d3
(E)-β-Ionone-d₃ (β-Lonone-d₃) is deuterium-labeled (E)-β-Ionone (HY-W015084A) .

HY-10844S1

Pretomanid-d5
Pretomanid-d₅ is deuterated labeled Pretomanid (HY-10844). Pretomanid (PA-824) is an antibiotic used for the research of multi-drug-resistant tuberculosis affecting the lungs. Pretomanid exhibits a sub-micromolar MIC against M. tuberculosis (MTB). The MIC values of PA-824 against a panel of MTB pan-sensitive and Rifampin mono-resistant clinical isolates range from 0.015 to 0.25 μg/mL.

HY-N0367S

Trans-Anethole-d3

Trans-Anethole-d3 is deuterated labeled Trans-Anethole (HY-N0367). Trans-Anethole ((E)-Anethole) is an orally active phenylpropene derivative found in Foeniculum vulgare that is estrogenic at low concentrations and cytotoxic at high concentrations in tumor cell lines. Trans-Anethole also has anti-aflatoxin, anti-thrombotic and anti-diabetic activities. Trans-Anethole is an important odor component in plants such as fennel, myrtle, liquorice, and camphor ^[3] .

HY-10581AS

Gatifloxacin-d3 hydrochloride

Gatifloxacin-d₃ (hydrochloride) is the deuterium labeled Gatifloxacin (hydrochloride). Gatifloxacin hydrochloride (AM-1155; BMS-206584; PD135432) is a potent fluoroquinolone antibiotic with broad-spectrum antibacterial activity. Gatifloxacin hydrochloride inhibits bacterial type II topoisomerases (IC50=13.8 μg/ml for S. aureus topoisomerase IV) and E. coli DNA gyrase (IC50 = 0.109 μg/ml). Gatifloxacin hydrochloride can be used to treat bacterial conjunctivitis in vivo.

HY-N0683S1

2-ambo-Vitamin E-13C3
α-Vitamin E- ¹³C₃ is the ¹³C-labeled α-Vitamin E. α-Vitamin E ((+)-α-Tocopherol), a naturally occurring vitamin E form, is a potent antioxidant .

HY-16950BS

(E)-4-Hydroxytamoxifen-d5
(E)-4-Hydroxytamoxifen-d5 ((E)-Afimoxifene-d5) is the deuterium labeled (E)-4-Hydroxytamoxifen. (E)-4-Hydroxytamoxifen ((E)-Afimoxifene), the less active isomer of (Z)-4-hydroxytamoxifen, is an estrogen receptor modulator.

HY-Y0248AS

(E,E)-Farnesol-d6
(E,E)-Farnesol-d₆ is deuterium labeled Farnesol. Farnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candida albicans, and has the activity in inhibiting bacteria.

HY-B0456S3

Riboflavin-d3
Riboflavin-d₃ is the deuterium labeled Riboflavin. Riboflavin is an easily absorbed micronutrient with a key role in maintaining health in humans and other animals.

HY-Y1311S

Malic acid-d3
Malic acid-d₃ is the deuterium labeled Malic acid. Malic acid (Hydroxybutanedioic acid) is a dicarboxylic acid that is naturally found in fruits such as apples and pears. It plays a role in many sour or tart foods .

HY-B0131S2

Prostaglandin E1-d9
Prostaglandin E1-d₉ is deuterium labeled Prostaglandin E1.Prostaglandin E1 is a prostanoid receptor ligand, with Kis of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3, EP4, EP2, IP and EP1, respectively. Prostaglandin E1 induces vasodilation and inh

HY-Y1069S

(S)-Malic acid-d3 1 Publications Verification
(S)-Malic acid-d₃ is the deuterium labeled (S)-Malic acid. (S)-Malic acid ((S)-2-Hydroxysuccinic acid) is a dicarboxylic acid in naturally occurring form, contributes to the pleasantly sour taste of fruits and is used as a food additive .

HY-B1689AS

Methantheline-d3 bromide
Methantheline-d₃ (bromide) is the deuterium labeled Methantheline bromide .

HY-101952S1

Prostaglandin E2-d9
Prostaglandin E2-d₉ is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation .

HY-101952S

Prostaglandin E2-d4
Prostaglandin E2-d₄ is the deuterium labeled Prostaglandin E2. Prostaglandin E2 (PGE2) is a hormone-like substance that participate in a wide range of body functions such as the contraction and relaxation of smooth muscle, the dilation and constriction of blood vessels, control of blood pressure, and modulation of inflammation .

HY-W067056S1

Methyl(E)-cinnamate-d7
Methyl(E)-cinnamate-d₇ is the deuterium labeled Methyl (E)-cinnamate . Methyl (E)-cinnamate (EMC), a phytochemical constituent isolated from Alpinia katsumadai Hayata, is a natural flavor compound with anti-inflammatory properties. Methyl (E)-cinnamate is widely used in the food and commodity industry .

HY-W067056S

Methyl (E)-cinnamate-d5
Methyl (E)-cinnamate-d₅ is the deuterium labeled Methyl (E)-cinnamate . Methyl (E)-cinnamate (EMC), a phytochemical constituent isolated from Alpinia katsumadai Hayata, is a natural flavor compound with anti-inflammatory properties. Methyl (E)-cinnamate is widely used in the food and commodity industry .

HY-10984S1

Pomalidomide-d3
Pomalidomide-d₃ is the deuterium labeled Pomalidomide. Pomalidomide, the third-generation immunomodulatory agent, acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors .

HY-113465S

Leukotriene E4-d5
Leukotriene E4-d₅ is the deuterium labeled Leukotriene E4. Leukotriene E4 (LTE4) is produced by the action of dipeptidase on LTD4. Leukotriene E4 is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A). Leukotriene E4 accumulates in both plasma and urine and urinary excretion of Leukotriene E4 is most often used as an indicator of asthma.

HY-113323S

3-Methoxy-4-hydroxyphenylglycol-d3
3-Methoxy-4-hydroxyphenylglycol-d₃ is the deuterium labeled 3-Methoxy-4-hydroxyphenylglycol.

HY-B1773AS5

Sodium Propionate-d3
Sodium Propionate-d₃ is the deuterium labeled Sodium Propionate .

HY-17413S

Zidovudine-d3
Zidovudine-d₃ is the deuterium labeled Zidovudine. Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI), widely used to treat HIV infection.

HY-B0621S

Triclabendazole-d3
Triclabendazole-d₃ is the deuterium labeled Triclabendazole (HY-B0621). Triclabendazole is an orally active parasite inhibitor. Triclabendazole has anti-Leishmania activity and induces gasdermin E (GSDME)-dependent pyroptosis by caspase-3 activation. Triclabendazole can be used for the research of fasciola hepatica ^[3].

HY-W392083S

(1,3E,5E)-Undeca-1,3,5-triene-d5
(1,3E,5E)-Undeca-1,3,5-triene-d₅ is deuterated labeled (1,3E,5E)-Undeca-1,3,5-triene.

HY-B0715S3

Pentoxifylline-d3

Pentoxifylline-d₃ (BL-191-d₃) is deuterium labeled Pentoxifylline. Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation ^[3].

HY-B0607S

Nitisinone-d3

Nitisinone-d₃ (NTBC-d₃) is deuterium labeled Nitisinone. Nitisinone is an orally active, competitive and reversible 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) inhibitor with an IC₅₀ of 173 nM. Nitisinone promotes tyrosine accumulation in a dose-dependent manner. nitisinone can be used in studies of hereditary tyrosinemia type 1 (HT-1) (a rare genetic disorder) and albinism ^[3] .

HY-N0683S6

α-Vitamin E-d11
α-Vitamin E-d11 ((+)-α-Tocopherol-d11) is the deuterium labeled α-Vitamin E (HY-N0683). α-Vitamin E ((+)-α-Tocopherol), a naturally occurring vitamin E form, is a potent antioxidant .

HY-B0497S2

Niclosamide-d3
Niclosamide-d₃ (BAY2353-d₃) is deuterium labeled Niclosamide. Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research . Niclosamide is a *STAT3* inhibitor with an IC₅₀ of 0.25 μM in HeLa cells . Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells ^[3] .

HY-70002S

Deutenzalutamide
Deutenzalutamide (Enzalutamide-d₃) is a developed deuterium labeled Enzalutamide (MDV3100). Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells .

HY-134928AS

Pyridinium bisretinoid A2E-d4 TFA
Pyridinium bisretinoid A2E-d₄ TFA is the deuterium-labeled Pyridinium bisretinoid A2E (HY-134928). Pyridinium bisretinoid A2E (A2E)is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species ^[3] .

HY-W008794S

Normetanephrine-d3 hydrochloride
Normetanephrine-d₃ (hydrochloride) is the deuterium labeled Normetanephrine hydrochloride. Normetanephrine ((±)-Normetanephrine) hydrochloride is the O-methylated metabolite of norepinephrine (NE) .

HY-B0457AS

Clomipramine-d3
Clomipramine-d₃ is the deuterium labeled Clomipramine. Clomipramine is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with K_i of 0.14, 54 and 3 nM, respectively .

HY-66005S1

Acetaminophen-d3
Acetaminophen-d₃ is the deuterium labeled Acetaminophen. Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 25.8 μM; is a widely used antipyretic and analgesic agent ^[3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor .

HY-B0141AS

Alpha-Estradiol-d3
Alpha-Estradiol-d₃ is the deuterium labeled Alpha-Estradiol. Alpha-Estradiol is a weak estrogen and a 5α-reductase inhibitor which is used as a topical medication in the treatment of androgenic alopecia.

HY-N0176S

Dihydroartemisinin-d3
Dihydroartemisinin-d₃ is the deuterium labeled Dihydroartemisinin. Dihydroartemisinin is a potent anti-malaria agent.

HY-13756S2

Tacrolimus-d3
Tacrolimus-d₃ (FK506-d₃) is deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties .

HY-30151S

Methoxsalen-d3
Methoxsalen-d₃ is the deuterium labeled Methoxsalen[1]. Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight[2].

HY-B0457S

Clomipramine-d3 hydrochloride
Clomipramine-d₃ (hydrochloride) is a deuterium labeled Clomipramine hydrochloride. Clomipramine hydrochloride is a serotonin transporter (SERT), norepinephrine transporter (NET) dopamine transporter (DAT) blocker with K_i of 0.14, 54 and 3 nM, respectively .

HY-13777S1

Zoledronic acid-d3
Zoledronic acid-d3 is the deuterium labeled Zoledronic acid .

HY-N7148S

α-Vitamin E-d6
α-Vitamin E-d₆ is the deuterium labeled α-Vitamin E .

HY-A0070AS3

Liothyronine-d3
Liothyronine-d₃ is deuterated labeled Liothyronine (HY-A0070A). Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with K_is of 2.33 nM for hTRα and hTRβ, respectively ^[3].

HY-14566S3

Donepezil-d4
Donepezil-d₄ (E2020-d₄ (free base)) is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC₅₀s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively .

HY-W727525

Donepezil-d7
Donepezil-d₇ (E2020-d₇ (free base)) is deuterium labeled Donepezil. Donepezil (E2020 free base) is a specific and potent AChE inhibitor with IC₅₀s of 8.12 nM and 11.6 nM for bovine AChE and human AChE, respectively .

HY-B0647S1

Butylphthalide-d3
Butylphthalide-d₃ is the deuterium labeled Butylphthalide. Butylphthalide(3-n-Butylphthalide), an anti-cerebral-ischemia agent, is first isolated from the seeds of celery and showes efficacy in animal models of stroke.

HY-115127S

3-Methylanisole-d3
3-Methylanisole-d₃ is the deuterium labeled 3-Methylanisole (HY-115127) ^[1].3-Methylanisole is an intermediate in drug synthesis, which has antiseptic, antibacterial and protein stabilizing effects .

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Species:	Human (401) Virus (68) Rhesus Macaque (6) Rat (16) Mouse (61) Bovine (2) Xenopus laevis (1) Cynomolgus (21) E.coli (102) Rabbit (2) Staphylococcus aureus (2) Canine (5)
Tag:	SUMO (49) GST (45) Flag (22) GFP (2) His (469) Tag Free (91) Strep (27) Avi (47) Myc (26) HA (1) MBP (3) Trx (1) Fc (94) B2M (1)
Source:	HEK293 (281) E. coli Cell-free (4) CHO (1) CHO (3) Sf9 insect cells (88) P. pastoris (19) E. coli (294)


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(E/Z)-Capsaicin-d<sub>3</sub>

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