Nucleoside Phosphoramidites

Nucleoside phosphoramidites are derivatives of natural or synthetic nucleosides and are used to synthesize oligonucleotides, relatively short fragments of nucleic acid and their analogs. Nucleoside phosphoramidites were first introduced in 1981 by Beaucage and Caruthers. These nucleoside phosphoramidites permit the sequential addition of new bases to the DNA chain in an exquisitely simple and exceptionally efficient cyclic reaction. A standard phosphoramidite molecule contains a phosphite instead of the typical phosphate in nucleotides, as well as four specific protecting groups. These groups provide stable protection, but can be easily removed when necessary.

Nucleoside Phosphoramidites (193):

Cat. No.	Product Name	CAS No.	Purity	Chemical Structure

HY-W008662

2'-Deoxy-5'-O-DMT-2'-fluorouridine	146954-74-7	99.94%
2'-Deoxy-5'-O-DMT-2'-fluorouridine, a nucleoside analogue, is a 5’-O-DMTr-5-FUDR derivative with potent anti-yellow fever (YFV) activity.

HY-W008848

DMT-dG(ib) Phosphoramidite	93183-15-4	99.71%
DMT-dG(ib) Phosphoramidite is typically used in the synthesis of DNA.

HY-W006102

Bz-rA Phosphoramidite	104992-55-4	99.03%
Bz-rA Phosphoramidite is used for ribonucleotides modification.

HY-21242

MMT-Hexylaminolinker Phosphoramidite	114616-27-2	≥98.0%
MMT-Hexylaminolinker Phosphoramidite is a cleavable linker. MMT-Hexylaminolinker Phosphoramidite can be used to syntheses oligonucleotide gapmers or other nucleic acid molecules.

HY-148505

5'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite)	1197033-17-2	99.17%
5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is a potent nucleic acid analog. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite blongs to modified antisense oligonucleotide. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite allows the formation of a specific conformation of the furanose ring of the oligonucleotide through the introduction of a cEt modification, enhancing the ability to hybridize to complementary RNA. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is mainly used in the research of regulation of gene expression related to metabolic diseases, cardiovascular diseases, cancers and the development of antisense compounds.

HY-148506

5'-ODMT cEt m5U Phosphoramidite (Amidite)	1197033-22-9	99.25%
5'-ODMT cEt m5U Phosphoramidite Amidite is a locked nucleic acid (LNA) analog. 5'-ODMT cEt m5U Phosphoramidite Amidite shows excellent safety and antisense activity in mice.

HY-45409

DMT-2′Fluoro-dU Phosphoramidite	146954-75-8	98.83%
DMT-2′Fluoro-dU Phosphoramidite could be used for nucleoside modification.

HY-W010702

5'-O-DMT-N2-ibu-dG	68892-41-1	≥98.0%
5'-O-DMT-N2-ibu-dG (N2-Isobutyryl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyguanosine) is a deoxynucleoside which can be used in the preparation of oligonucleotides.

HY-138610

5'-O-DMT-Bz-rC	81246-76-6	99.69%
5'-O-DMT-Bz-Rc is a modified nucleoside and can be used to synthesize DNA or RNA.

HY-W013059

DMT-dA(bz) Phosphoramidite	98796-53-3	99.78%
DMT-dA(bz) Phosphoramidite is typically used in the synthesis of DNA.

HY-W013068

DMT-dT Phosphoramidite	98796-51-1	98.74%
DMT-dT Phosphoramidite is typically used in the synthesis of DNA.

HY-21545

5'-O-DMT-Bz-rA	81246-82-4	≥98.0%
5'-O-DMT-Bz-rA is an intermediate for cyclic di-nucleotide compounds synthesis.

HY-20140

5'-O-DMT-dT	40615-39-2	99.09%
5'-O-DMT-dT (5'-O-(4,4'-Dimethoxytrityl)thymidine) is a nucleoside derivative which can be used in the preparation of oligonucleotides.

HY-W570886

2'-O-MOE-U	163759-97-5
2'-O-MOE-U is a phosphoramidite, can be used for oligonucleotide synthesis.

HY-138586

DMT-dC(ac) Phosphoramidite	154110-40-4	99.76%
DMT-dC(ac) Phosphoramidite (compound 30f) is a phosphoramidite derivative that can be used for the oligonucleotide synthesis.

HY-W013077

N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine	64325-78-6	≥98.0%
N6-Benzoyl-5′-O-(4,4′-dimethoxytrityl)-2′-deoxyadenosine can be used as an intermediate.

HY-138603

5'-O-DMT-N4-Bz-2'-F-dC	146954-77-0	99.85%
5'-O-DMT-N4-Bz-2'-F-dC is a nucleoside with protective and modification effects.

HY-W101391

DMT-2'O-Methyl-rU Phosphoramidite	110764-79-9	99.70%
DMT-2'O-Methyl-rU Phosphoramidite (2'-O-Me-U Phosphoramidite) is a 2'-O-Me derivative, and can be used for oligonucleotide synthesis.

HY-W102322

5'-O-DMT-2'-TBDMS-Uridine	81246-80-2	99.11%
5'-O-DMT-2'-TBDMS-Uridine is a deoxyribonucleoside used for the oligonucleotide synthesis.

HY-W570885

2'-O-MOE-rC	251647-54-8	≥98.0%
2'-O-MOE-rC is a 2'-O-MOE modified nucleoside. 2'-O-MOE-rC can be used for synthesis of DNA.

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