2. Oligonucleotides
  3. Nucleoside Phosphoramidites

Nucleoside Phosphoramidites

Nucleoside phosphoramidites are derivatives of natural or synthetic nucleosides and are used to synthesize oligonucleotides, relatively short fragments of nucleic acid and their analogs. Nucleoside phosphoramidites were first introduced in 1981 by Beaucage and Caruthers. These nucleoside phosphoramidites permit the sequential addition of new bases to the DNA chain in an exquisitely simple and exceptionally efficient cyclic reaction. A standard phosphoramidite molecule contains a phosphite instead of the typical phosphate in nucleotides, as well as four specific protecting groups. These groups provide stable protection, but can be easily removed when necessary.

 

Nucleoside Phosphoramidites (158):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W008848
    DMT-dG(ib) Phosphoramidite 93183-15-4 99.71%
    DMT-dG(ib) Phosphoramidite is a phosphoramidite monomer that can be used in the synthesis of DNA and related molecules.
    DMT-dG(ib) Phosphoramidite
  • HY-138580
    2'-OMe-A(Bz) Phosphoramidite 110782-31-5 99.74%
    2'-OMe-A(Bz) Phosphoramidite is a modified phosphoramidite monomer, which can be used for the oligonucleotide synthesis.
    2'-OMe-A(Bz) Phosphoramidite
  • HY-W006102
    Bz-rA Phosphoramidite 104992-55-4 99.03%
    Bz-rA Phosphoramidite is used for ribonucleotides modification.
    Bz-rA Phosphoramidite
  • HY-W013068
    DMT-dT Phosphoramidite 98796-51-1 98.83%
    DMT-dT Phosphoramidite is typically used in the synthesis of DNA.
    DMT-dT Phosphoramidite
  • HY-148505
    5'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite) 1197033-17-2 99.17%
    5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is a potent nucleic acid analog. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite blongs to modified antisense oligonucleotide. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite allows the formation of a specific conformation of the furanose ring of the oligonucleotide through the introduction of a cEt modification, enhancing the ability to hybridize to complementary RNA. 5'-ODMT cEt N-Bzm5 C Phosphoramidite Amidite is mainly used in the research of regulation of gene expression related to metabolic diseases, cardiovascular diseases, cancers and the development of antisense compounds.
    5'-ODMT cEt N-Bzm5 C Phosphoramidite (Amidite)
  • HY-21242
    MMT-Hexylaminolinker Phosphoramidite 114616-27-2 98.0%
    MMT-Hexylaminolinker Phosphoramidite is a cleavable linker. MMT-Hexylaminolinker Phosphoramidite can be used to syntheses oligonucleotide gapmers or other nucleic acid molecules.
    MMT-Hexylaminolinker Phosphoramidite
  • HY-148506
    5'-ODMT cEt m5U Phosphoramidite (Amidite) 1197033-22-9 99.76%
    5'-ODMT cEt m5U Phosphoramidite Amidite is a locked nucleic acid (LNA) analog. 5'-ODMT cEt m5U Phosphoramidite Amidite shows excellent safety and antisense activity in mice.
    5'-ODMT cEt m5U Phosphoramidite (Amidite)
  • HY-W013059
    DMT-dA(bz) Phosphoramidite 98796-53-3 99.78%
    DMT-dA(bz) Phosphoramidite is typically used in the synthesis of DNA.
    DMT-dA(bz) Phosphoramidite
  • HY-45409
    DMT-2′Fluoro-dU Phosphoramidite 146954-75-8 99.98%
    DMT-2’ Fluoro-dU Phosphoramidite (2'-F-dU Phosphoramidite) is a uridine phosphoramidite with a fluorine in the 2’ position. DMT-2’ Fluoro-dU Phosphoramidite could be used for nucleoside modification and synthesis of DNA.
    DMT-2′Fluoro-dU Phosphoramidite
  • HY-138586
    DMT-dC(ac) Phosphoramidite 154110-40-4 99.76%
    DMT-dC(ac) Phosphoramidite (compound 30f) is a phosphoramidite derivative that can be used for the oligonucleotide synthesis.
    DMT-dC(ac) Phosphoramidite
  • HY-148503
    5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) 1197033-19-4 98.55%
    5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is a nucleoside phosphoramidite monomer used to synthesize locked nucleic acid (LNA) analog oligonucleotides. It can be used as a building block of antisense oligonucleotides (ASOs) to target complementary RNA sequences. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) locks the furanose ring into an N-type conformation through 2',4'-constrained ethyl (cEt) modification, enhancing hybridization affinity and mismatch discrimination with RNA, while significantly improving the resistance of oligonucleotides to exonuclease digestion. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) mediates RNase H-dependent mRNA degradation or inhibits translation by forming a stable hybrid with RNA, thereby achieving gene expression regulation. 5'-ODMT cEt N-Bz A Phosphoramidite (Amidite) is mainly used in the development of antisense drugs, gene function research and oligonucleotide synthesis related to disease treatment.
    5'-ODMT cEt N-Bz A Phosphoramidite (Amidite)
  • HY-W570886
    2'-O-MOE-U 163759-97-5
    2'-O-MOE-U is a phosphoramidite, can be used for oligonucleotide synthesis.
    2'-O-MOE-U
  • HY-W101391
    DMT-2'O-Methyl-rU Phosphoramidite 110764-79-9 99.70%
    DMT-2'O-Methyl-rU Phosphoramidite (2'-O-Me-U Phosphoramidite) is a 2'-O-Me derivative, and can be used for oligonucleotide synthesis.
    DMT-2'O-Methyl-rU Phosphoramidite
  • HY-138585
    DMT-dG(dmf) Phosphoramidite 330628-04-1 99.71%
    DMT-dG(dmf) Phosphoramidite is a phosphinamide monomer that can be used in the preparation of oligonucleotides
    DMT-dG(dmf) Phosphoramidite
  • HY-45491
    Dmt-2'-f-dc(ac) amidite 159414-99-0 99.53%
    Dmt-2'-f-dc(ac) amidite (2'-F-Ac-dC Phosphoramidite) is a phosphoramidite which can be used in the preparation of cyclic purine dinucleotides.
    Dmt-2'-f-dc(ac) amidite
  • HY-148504
    5'-ODMT cEt G Phosphoramidite (Amidite) 945628-66-0 99.05%
    5'-ODMT cEt G Phosphoramidite Amidite is a potent nucleic acid analog. 5'-ODMT cEt G Phosphoramidite Amidite shows excellent safety and antisense activity.
    5'-ODMT cEt G Phosphoramidite (Amidite)
  • HY-21648
    2'-OMe-Ac-C Phosphoramidite 199593-09-4 99.53%
    2'-OMe-Ac-C Phosphoramidite is a modified phosphoramidite and can be used for the oligonucleotide synthesis. 2'-OMe-Ac-C Phosphoramidite contributes to improving the stability and activity of oligonucleotides.
    2'-OMe-Ac-C Phosphoramidite
  • HY-138579
    2'-OMe-G(ibu) Phosphoramidite 150780-67-9 99.42%
    2'-OMe-G(ibu) Phosphoramidite (DMT-2'-O-Methyl-rG(ib) Phosphoramidite) is a modified phosphoramidite monomer that can be used for the oligonucleotide synthesis.
    2'-OMe-G(ibu) Phosphoramidite
  • HY-104014
    DMT-2'O-MOE-rG(ib) Phosphoramidite 251647-55-9
    DMT-2'O-MOE-rG(ib) Phosphoramidite belongs to cyanoethyl-protected nucleoside phosphoramidites. DMT-2'O-MOE-rG(ib) Phosphoramidite is a derivative of nucleotide and guanosine. DMT-2'O-MOE-rG(ib) Phosphoramidite can be used for the stereochemical synthesis of phosphorothioate oligonucleotides.
    DMT-2'O-MOE-rG(ib) Phosphoramidite
  • HY-W570885
    2'-O-MOE-rC 251647-54-8 98.0%
    2'-O-MOE-rC is a 2'-O-MOE modified nucleoside. 2'-O-MOE-rC can be used for synthesis of DNA.
    2'-O-MOE-rC