EHD Protein

Eps15 Homology Domain (EHD) Protein

The EHD protein family (Eps15 Homology Domain-containing proteins) is a key group of proteins in mammalian cells responsible for endocytic transport. They regulate the internalization and recycling of membrane proteins and receptors by controlling cellular endocytosis and exocytosis processes. The C-terminal of EHD proteins contains an Eps15 Homology Domain, which is crucial for regulating intracellular transport functions. EHD proteins can regulate membrane transport processes through interactions with proteins rich in NPF sequences and Rab GTPases. The EHD protein family includes four members: EHD1, EHD2, EHD3, and EHD4. Studies have shown that EHD1 primarily regulates the recycling of the transferrin receptor from the recycling endosome back to the cell membrane.
EHD protein activity is related to the development of Alzheimer's disease. By regulating the transport and processing of BACE1, it affects the production of β-amyloid, a key mechanism in the pathogenesis of the disease^[1]^[2]^[3].

References:

[1]. Traffic. 2008 Dec;9(12):2043-52. [Content Brief]

[2]. Trends Cell Biol. 2011 Feb;21(2):122-31.

[3]. Naslavsky N, et al. EHD proteins: key conductors of endocytic transport. Trends Cell Biol. 2011 Feb;21(2):122-31. [Content Brief]

[4]. Buggia-Prévot V, et al. A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer's disease Aβ production. Cell Rep. 2013 Dec 26;5(6):1552-63. [Content Brief]

EHD Protein Inhibitor (1)

EHD Protein Related Products (1):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-158415

ATPase-IN-4	Inhibitor
ATPase-IN-4 (Compound MS1) inhibits the ATPase activity of EHD4 (IC₅₀: 0.92 μM). ATPase-IN-4 also inhibits EHD2 enzymatic activity

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