1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. 3β-HSD

3β-HSD

3β-HSD

3β-HSD (3β-Hydroxysteroid Dehydrogenase) is a key enzyme in the steroid hormone biosynthesis pathway, catalyzing the conversion of precursors such as pregnenolone and dehydroepiandrosterone (DHEA) into progesterone and androstenedione, which are further used to synthesize glucocorticoids, mineralocorticoids, androgens, and estrogens.
3β-HSD exists in multiple isoforms in both humans and mice. In humans, the main isoforms are HSD3B1 (placenta, skin, mammary gland) and HSD3B2 (adrenal glands, gonads), with HSD3B2 being essential for the biosynthesis of glucocorticoids, mineralocorticoids, and sex hormones. In mice, 3β-HSD I is predominantly expressed in the adrenal glands and gonads, playing a key role in steroidogenesis, whereas 3β-HSD VI is expressed in the decidua and trophoblast cells during early pregnancy, regulating progesterone synthesis and potentially supporting embryo survival through immune suppression.
3β-HSD plays a crucial role in steroid biosynthesis, placental function, sex hormone metabolism, and endocrine disorders. HSD3B2 mutations can cause congenital 3β-HSD deficiency, leading to adrenal insufficiency, abnormal sexual development, and electrolyte imbalance. Dysregulation of HSD3B1 and HSD3B2 activity can result in androgen excess, contributing to polycystic ovary syndrome (PCOS). Moreover, HSD3B1 dysfunction has been implicated in recurrent early pregnancy loss, while 3β-HSD V, primarily expressed in the male liver, may promote the progression of androgen-dependent prostate cancer when aberrantly expressed[1].

3β-HSD Isoform Specific Products:

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-14281
    Trilostane
    Inhibitor 99.81%
    Trilostane (Win 24540) is a competitive and orally active 3-β-hydroxysteroiddehydrogenase (3β-HSD) inhibitor. Trilostane is a synthetic nonhormonal steroid. Trilostane can be used for the research of breast cancer and prostate cancer.
    Trilostane
  • HY-105128
    Epostane
    ≥99.0%
    Epostane (WIN 32729) is an orally active inhibitor for 3β-hydroxysteroid dehydrogenase, with IC50 of 1.45 nM. Epostane blocks ovulation and pregnancy in rats.
    Epostane
  • HY-174244
    3βHSD1-IN-1
    Inhibitor
    3βHSD1-IN-1 (Compound 46) is a 3β-hydroxysteroid dehydrogenase 1 (3βHSD1) inhibitor with an IC50 of 55 nM. 3βHSD1-IN-1 can effectively inhibit androgen receptor activity. 3βHSD1-IN-1 can be used in the research of diseases such as prostate cancer.
    3βHSD1-IN-1

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