2. Signaling Pathways
  3. Neuronal Signaling
  4. Dimethylargininase (DDAH)

Dimethylargininase (DDAH)

Dimethylarginine Dimethylaminohydrolase

Dimethylarginase (DDAH) hydrolyzes asymmetric dimethylarginine (ADMA) to regulate the production of nitric oxide (NO) , and its two isozymes, DDAH1 and DDAH2, are expressed in various tissues. DDAH is a potential inhibitory target for diseases such as cardiovascular disease, neurodegenerative diseases, and cancer.

Dimethylargininase (DDAH) Related Products (3):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-16958
    PD 404182
    		Inhibitor 98.98%
    PD 404182 is a potent and competitive inhibitor of human dimethylarginine dimethylaminohydrolase 1 (DDAH1), with an IC50 of 9 μM. PD 404182 exhibits antiangiogenic and antiviral activity in vitro.
    PD 404182
  • HY-133126
    hDDAH-1-IN-1
    		Inhibitor
    hDDAH-1-IN-1 (compound 8a) is a potent and selective non-amino acid catalytic site inhibitor of human dimethylarginine dimethylaminohydrolase-1 (hDDAH-1), with a Ki of 18 μM. DDAH mediates ADMA metabolism, thereby regulating nitric oxide production in a variety of disease states.
    hDDAH-1-IN-1
  • HY-16958R
    PD 404182 (Standard)
    		Inhibitor
    Paris saponin VII (Standard) is the analytical standard of Paris saponin VII. This product is intended for research and analytical applications. Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia.
    PD 404182 (Standard)