2. Signaling Pathways
  3. Cell Cycle/DNA Damage
    Cytoskeleton
  4. MASTL

MASTL

Microtubule‐associated serine/threonine kinase like

Microtubule‐associated serine/threonine kinase like (MASTL), also known as Greatwall (Gwl), is an important mitotic kinase that regulates mitotic progression of normal or transformed cells. The best-characterized substrates of MASTL kinase are cAMP-regulated phosphoprotein 19 (Arpp19) and endosulfine alpha (ENSA, identified due to its high homology with Arpp19), both of which contain the conserved MASTL phosphorylation motif FDSGDY. This kinase function of MASTL has primarily been associated with cell-cycle progression, where it facilitates effective mitotic exit through downregulation of the B55 subunit of protein phosphatase 2A (PP2A). This prevents excessive dephosphorylation by PP2A and mitotic collapse upon nuclear envelope breakdown.

MASTL Related Products (6):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-137552
    MKI-1
    		Inhibitor 98.13%
    MKI-1, an inhibitor of MASTL (microtubule-associated serine/threonine kinase-like) with an IC50 of 9.9 μM, exerts antitumor and radiosensitizer activities through PP2A activation in breast cancer.
    MKI-1
  • HY-156716
    MASTL-IN-2
    		Inhibitor 98.49%
    MASTL-IN-2 is an MASTL (microtubule-associated serine/threonine kinase-like) inhibitor. MASTL-IN-2 inhibits human epithelial MIA PaCa cancer cell proliferation with IC50 of 2.8 nM.
    MASTL-IN-2
  • HY-156715
    MASTL-IN-1
    		Inhibitor 99.54%
    MASTL-IN-1 is a MASTL (microtubule-associated serine/threonine kinase-like) inhibitor, which is involved in cell proliferation, migration, and invasion. MASTL-IN-1 has potential in cancer research.
    MASTL-IN-1
  • HY-W231513
    MASTL/Aurora A-IN-1
    		Inhibitor
    MASTL/Aurora A-IN-1 (Compound MA4) is a dual inhibitor of MASTL and Aurora A kinases with IC50 values of 0.56 μM and 0.16 μM, respectively. MASTL/Aurora A-IN-1 has broad-spectrum anticancer activity and has potent anticancer activity against SR (leukemia), K-562 (leukemia), MDA-MB-435 (melanoma), MOLT-4 (leukemia), and SK-MEL-2 (melanoma) cell lines in NCI-60 cancer cell lines with GI50 values of 0.023, 0.032, 0.037, 0.044, and 0.051 μM, respectively. MASTL/Aurora A-IN-1 inhibits Aurora A and MASTL kinases, inducing cell cycle G2/M arrest, thereby inhibiting cancer cell proliferation. MASTL/Aurora A-IN-1 can be used in cancer research, especially for tumors with dysregulated mitosis.
    MASTL/Aurora A-IN-1
  • HY-162731
    MASTL-IN-3
    		Inhibitor
    MASTL-IN-3 (compound 60) is a potent MASTL inhibitor with a pIC50 value of 9.10 M. MASTL-IN-3 shows anti-proliferative activity.
    MASTL-IN-3
  • HY-162732
    MASTL-IN-4
    		Inhibitor
    MASTL-IN-4(compound 70) is a potent MASTL inhibitor with a pIC50 value of 9.15. MASTL-IN-4 shows anti-proliferative activity.
    MASTL-IN-4