1. Recombinant Proteins
  2. Receptor Proteins
  3. Notch family

The Notch receptors are evolutionarily highly conserved single-pass transmembrane proteins that normally communicate signals upon binding to transmembrane ligands expressed on adjacent cells. The Notch family includes 4 receptors, NOTCH1, NOTCH2, NOTCH3, and NOTCH4, whose ligands include JAG1, JAG2, DLL1, DLL3, and DLL4. All of Notch receptors have an extracellular domain containing multiple epidermal growth factor (EGF)-like repeats and an intracellular region containing the RAM domain, ankyrin repeats, and a C-terminal PEST domain. Notch receptors function in highly conserved intercellular signaling pathway, which is highly conserved from Drosophila to humans, and play an important role in the regulation of cellular proliferation, differentiation and apoptosis. Constitutive activation of Notch signaling has been shown to result in excessive cellular proliferation and a wide range of malignancies, including leukemia, glioblastoma and lung and breast cancers.

Cat. No. Product Name / Synonyms Species Source
  • HY-P75294
    Delta-like protein 4/DLL4 Protein, Human (HEK293, Fc)

    Delta-like protein 4; Delta4; DLL4

    Human HEK293
    The DLL4 protein, a homolog of the Drosophila delta gene family, encodes Notch ligands with a DSL domain, EGF repeats, and a transmembrane domain. DLL4 is widely expressed in tissues, including placenta (RPKM 11.5), fat (RPKM 11.2), and 22 others. Delta-like protein 4/DLL4 Protein, Human (HEK293, Fc) is the recombinant human-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Delta-like protein 4/DLL4 Protein, Human (HEK293, Fc) is 498 a.a., with molecular weight of 100-110 kDa.
  • HY-P70111
    Delta-like protein 4/DLL4 Protein, Human (HEK293, His)

    rHuDelta-like protein 4/DLL4, His; Delta-like protein 4; Drosophila Delta homolog 4; Delta4; DLL4

    Human HEK293
    Delta-like protein 4 (DLL4) functions as a Notch ligand and activates NOTCH1 and NOTCH4 in the Notch signaling pathway. It regulates angiogenesis by inhibiting endothelial cell proliferation, migration, and angiogenesis. Delta-like protein 4/DLL4 Protein, Human (HEK293, His) is the recombinant human-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P75292
    Delta-like protein 4/DLL4 Protein, Mouse (HEK293, His)

    Delta-like protein 4; Delta4; DLL4

    Mouse HEK293
    Delta-like 4/DLL4 protein is a key player in the Notch signaling pathway, acting as a ligand to activate NOTCH1 and NOTCH4. In angiogenesis, DLL4 regulates endothelial cell proliferation, migration, and angiogenic sprouting. Delta-like protein 4/DLL4 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-His labeled tag. The total length of Delta-like protein 4/DLL4 Protein, Mouse (HEK293, His) is 525 a.a., with molecular weight of ~68 kDa.
  • HY-P72972
    Delta-like protein 4/DLL4 Protein, Human (HEK293)

    Delta-like protein 4; Delta4; DLL4

    Human HEK293
    Delta-like protein 4 (DLL4) functions as a Notch ligand and activates NOTCH1 and NOTCH4 in the Notch signaling pathway. It regulates angiogenesis by inhibiting endothelial cell proliferation, migration, and angiogenesis. Delta-like protein 4/DLL4 Protein, Human (HEK293) is the recombinant human-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with tag free. The total length of Delta-like protein 4/DLL4 Protein, Human (HEK293) is 498 a.a., with molecular weight of 55-70 kDa.
  • HY-P78115
    Delta-like protein 3/DLL3 Protein, Human (Biotinylated, HEK293, His)

    Delta3; DLL3; Pudgy; SCDO1; SCDO1delta3

    Human HEK293
    Delta-like protein 3/DLL3 stands out as a key regulator of neurogenesis and cell differentiation. As an inhibitor of primary neurogenesis, DLL3 plays a crucial role in guiding neurons along specific differentiation pathways. Delta-like protein 3/DLL3 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived Delta-like protein 3/DLL3 protein, expressed by HEK293 , with N-His labeled tag.
  • HY-P78116
    Delta-like protein 4/DLL4 Protein, Human (Biotinylated, HEK293, His)

    DLL4; MGC126344; notch ligand DLL4; Delta4; Delta-like 4

    Human HEK293
    Delta-like protein 4 (DLL4) functions as a Notch ligand and activates NOTCH1 and NOTCH4 in the Notch signaling pathway. It regulates angiogenesis by inhibiting endothelial cell proliferation, migration, and angiogenesis. Delta-like protein 4/DLL4 Protein, Human (Biotinylated, HEK293, His) is the recombinant human-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-His labeled tag. The total length of Delta-like protein 4/DLL4 Protein, Human (Biotinylated, HEK293, His) is 498 a.a., with molecular weight of 60-70 kDa.
  • HY-P73258
    Jagged-1/JAG1 Protein, Human (HEK293, His)

    AGS; Alagille syndrome; AWS; CD339; HJ1; JAG1; Jagged 1; JAGL1

    Human HEK293
    Jagged-1/JAG1 protein is a ligand for multiple Notch receptors and crucially mediates Notch signaling through interactions with NOTCH1, NOTCH2, and NOTCH3. Its role in hematopoiesis suggests its involvement in the regulation of blood cell development. Jagged-1/JAG1 Protein, Human (HEK293, His) is the recombinant human-derived Jagged-1/JAG1 protein, expressed by HEK293 , with C-10*His labeled tag.
  • HY-P72970
    Delta-like protein 1/DLL1 Protein, Mouse (HEK293, His)

    Delta-like protein 1; Delta1; Dll1-EC; Dll1-TMIC; Dll1

    Mouse HEK293
    DLL1 protein is a transmembrane ligand for NOTCH1, NOTCH2 and NOTCH3 receptors and participates in cis- and trans-interactions. Trans interactions trigger mechanical forces through clathrin-mediated endocytosis, involving ligand ubiquitination, EPN1 interactions, and actin polymerization. Delta-like protein 1/DLL1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Delta-like protein 1/DLL1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Delta-like protein 1/DLL1 Protein, Mouse (HEK293, His) is 499 a.a., with molecular weight of ~65 kDa.
  • HY-P77641
    Delta-like protein 3/DLL3 Protein, Cynomolgus (HEK293, His)

    Delta3; DLL3; Pudgy; SCDO1; SCDO1delta3

    Cynomolgus HEK293
    Delta-like protein 3/DLL3 stands out as a key regulator of neurogenesis and cell differentiation. As an inhibitor of primary neurogenesis, DLL3 plays a crucial role in guiding neurons along specific differentiation pathways. Delta-like protein 3/DLL3 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Delta-like protein 3/DLL3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Delta-like protein 3/DLL3 Protein, Cynomolgus (HEK293, His) is 451 a.a., with molecular weight of 52-62 kDa.
  • HY-P7841
    Delta-like protein 1/DLL1 Protein, Human (HEK293, His)

    rHuDelta-like protein 1/DLL1, His; Delta-like protein 1; Drosophila Delta homolog 1; Delta1; H-Delta-1; DLL1

    Human HEK293
    DLL1 protein is a transmembrane ligand for NOTCH1, NOTCH2 and NOTCH3 receptors and participates in cis- and trans-interactions. Trans interactions trigger mechanical forces involving clathrin-mediated endocytosis, ligand ubiquitination, EPN1 interactions, and actin polymerization. Delta-like protein 1/DLL1 Protein, Human (HEK293, His) is the recombinant human-derived Delta-like protein 1/DLL1 protein, expressed by HEK293 , with C-6*His labeled tag.
  • HY-P700456
    Delta-like protein 3/DLL3 Protein, Human (HEK293, His)

    SCDO1; DLL3; delta like canonical Notch ligand 3; Drosophila Delta homolog 3 ; Delta3

    Human HEK293
    Delta-like protein 3/DLL3 stands out as a key regulator of neurogenesis and cell differentiation. As an inhibitor of primary neurogenesis, DLL3 plays a crucial role in guiding neurons along specific differentiation pathways. Delta-like protein 3/DLL3 Protein, Human (HEK293, His) is the recombinant human-derived Delta-like protein 3/DLL3 protein, expressed by HEK293 , with C-6*His labeled tag.
  • HY-P72970A
    Delta-like protein 1/DLL1 Protein, Mouse (HEK293, C-His)

    Delta-like protein 1; Delta1; Dll1-EC; Dll1-TMIC; Dll1

    Mouse HEK293
    DLL1 protein is a transmembrane ligand for NOTCH1, NOTCH2 and NOTCH3 receptors and participates in cis- and trans-interactions. Trans interactions trigger mechanical forces through clathrin-mediated endocytosis, involving ligand ubiquitination, EPN1 interactions, and actin polymerization. Delta-like protein 1/DLL1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Delta-like protein 1/DLL1 protein, expressed by HEK293 , with C-His labeled tag.
  • HY-P70399
    Jagged-1/JAG1 Protein, Human (HEK293, Fc)

    rHuJagged-1/JAG1, Fc; Protein jagged-1 I; Jagged-1; JAGL1; HJ1; JAG1 and CD339

    Human HEK293
    Jagged-1/JAG1 protein is a ligand for multiple Notch receptors and crucially mediates Notch signaling through interactions with NOTCH1, NOTCH2, and NOTCH3. Its role in hematopoiesis suggests its involvement in the regulation of blood cell development. Jagged-1/JAG1 Protein, Human (HEK293, Fc) is the recombinant human-derived Jagged-1/JAG1 protein, expressed by HEK293 , with C-hFc labeled tag.
  • HY-P71167
    NOTCH2 Protein, Human (HEK293, His)

    AGS2; hN2; Notch homolog 2; Notch2; Notch-2; HJCYS

    Human HEK293
    NOTCH2 protein is a receptor for ligands such as JAG1, JAG2 and DLL1 and is critical for cell fate determination. Ligand activation promotes cleavage and releases NICD, which forms a transcription activator complex with RBPJ/RBPSUH, affecting cell differentiation, proliferation and apoptosis. NOTCH2 Protein, Human (HEK293, His) is the recombinant human-derived NOTCH2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of NOTCH2 Protein, Human (HEK293, His) is 505 a.a., with molecular weight of 60-70 kDa.
  • HY-P73324
    NOTCH1 Protein, Mouse (sf9, His)

    Neurogenic locus notch homolog protein 1; Notch 1; Motch A; mT14

    Mouse Sf9 insect cells
    NOTCH1 Protein acts as a receptor for membrane-bound ligands (JAG1, JAG2, and DLL1), determining cell fate.Upon activation, NICD forms a transcriptional activator complex, influencing differentiation, proliferation, and apoptosis.NOTCH1 negatively regulates angiogenesis, endothelial cell behavior, and impacts various developmental processes.It interacts with multiple partners, illustrating its involvement in signaling networks.NOTCH1 Protein, Mouse (sf9, His) is the recombinant mouse-derived NOTCH1 protein, expressed by Sf9 insect cells , with C-His labeled tag.
  • HY-P73742
    NOTCH1 Protein, Human (HEK293, Fc)

    Neurogenic locus notch homolog protein 1; Notch 1; Motch A; mT14

    Human HEK293
    NOTCH1 protein is a receptor for the ligands JAG1, JAG2 and DLL1 and is critical for cell fate decisions. Upon ligand activation, NICD forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes in the cleavage site enhancer. NOTCH1 Protein, Human (HEK293, Fc) is the recombinant human-derived NOTCH1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of NOTCH1 Protein, Human (HEK293, Fc) is 508 a.a., with molecular weight of ~79.7 kDa.
  • HY-P75295
    Delta-like protein 1/DLL1 Protein, Rat (HEK293, His)

    Delta-like protein 1; Delta1; Dll1-EC; Dll1-TMIC; Dll1

    Rat HEK293
    Delta-like protein 1 (DLL1) is a transmembrane ligand for NOTCH1, NOTCH2, and NOTCH3 receptors and participates in cis- and trans-interactions with their extracellular domains. Upon interaction, DLL1 induces mechanical forces that promote Notch signaling by triggering NICD nuclear accumulation. Delta-like protein 1/DLL1 Protein, Rat (HEK293, His) is the recombinant rat-derived Delta-like protein 1/DLL1 protein, expressed by HEK293 , with C-His labeled tag. The total length of Delta-like protein 1/DLL1 Protein, Rat (HEK293, His) is 517 a.a., with molecular weight of ~81.7 kDa.
  • HY-P76872
    Delta-like protein 4/DLL4 Protein, Rhesus Macaque (HEK293, His)

    Delta-like protein 4; Delta4; DLL4

    Rhesus Macaque HEK293
    delta-like protein 4 involves in the Notch signaling pathway as Notch ligand, and activates NOTCH1 and NOTCH4. delta-like protein 4 involves in angiogenesis. Delta-like protein 4/DLL4 Protein, Rhesus Macaque (HEK293, His) is the recombinant Rhesus Macaque-derived Delta-like protein 4/DLL4 protein, expressed by HEK293 , with C-His labeled tag. The total length of Delta-like protein 4/DLL4 Protein, Rhesus Macaque (HEK293, His) is 502 a.a., with molecular weight of ~56.1 KDa.
  • HY-P78009
    Notch3 Protein, Human (HEK293, Fc)

    CADASIL; CASILneurogenic locus notch homolog protein 3; Notch (Drosophila) homolog 3; notch 3Notch homolog 3 (Drosophila); Notch homolog 3; Notch3; Notch-3

    Human HEK293
    Notch 3 protein is a receptor for the ligands JAG1, JAG2 and DLL1 and plays a crucial regulatory role in cell fate determination. Upon ligand activation, NICD forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes within the enhancer of the cleavage site. Notch3 Protein, Human (HEK293, Fc) is the recombinant human-derived Notch3 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Notch3 Protein, Human (HEK293, Fc) is 428 a.a., with molecular weight of 75-83 kDa.
  • HY-P78501
    NOTCH1 Protein, Human (HEK293, His-Avi)

    Notch-1; TAN1; NOTCH1; 9930111A19Rik; lin-12; Mis6; N1

    Human HEK293
    NOTCH1 protein is a receptor for the ligands JAG1, JAG2 and DLL1 and is critical for cell fate decisions. Upon ligand activation, NICD forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes in the cleavage site enhancer. NOTCH1 Protein, Human (HEK293, His-Avi) is the recombinant human-derived NOTCH1 protein, expressed by HEK293 , with C-Avi, C-His labeled tag. The total length of NOTCH1 Protein, Human (HEK293, His-Avi) is 508 a.a., with molecular weight of 70-80 kDa.
Cat. No. Product Name Effect Purity