1. Signaling Pathways
  2. Autophagy
  3. AUTACs


Autophagy-targeting chimeras

Autophagy-targeting chimera (AUTAC) degrades target proteins via lysosomal pathway rather than common proteasome pathway. One end of AUTAC is target protein ligand, the other end is a site of K63 ubiquitin modification, and the two parts are connected by linker. AUTAC induces recognition of LC3 receptors of autophagosomes by K63-linked polyubiquitination and then the Target-AUTAC complex was phagocytosed and transferred into lysosomal for degradation.

AUTACs Related Products (10):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-134640
    AUTAC4 2267315-04-6 99.31%
    AUTAC4 is a mitochondria-targeting autophagy-targeting chimera (AUTAC). AUTAC4 downregulates cytosolic proteins and promotes targeted mitochondrial turnover via mitophagy.
  • HY-134183
    AUTAC1 2241669-09-8
    AUTAC1 is a MetAP2-targeting autophagy-mediated degrader (AUTAC). AUTACs contain a degradation tag and a warhead to provide target specificity. AUTAC1 contains an FBnG (p-Fluorobenzyl Guanine) and a Fumagillol moiety. Fumagillol binds covalently to MetAP2.
  • HY-150408
    FBnG-(Cys-acetamide)-CH2-PEG3-CH2-CH2-CH2-NH2 2241669-84-9 98.03%
    FBnG-(Cys-acetamide)-CH2-PEG3-CH2-CH2-CH2-NH2 is a linker of AUTAC4. AUTAC4 contains an p-fluorobenzylguanine (FBnG) and a phenylindole moiety, which can induce K63-linked polyubiquitination and degradation of mitochondria in HeLa cells.
  • HY-134184
    AUTAC2 2241669-08-7
    AUTAC2 is a FKBP12-targeting autophagy-mediated degrader (AUTAC). AUTAC2 contains an FBnG (p-Fluorobenzyl Guanine) and an SLF (c ligand of FKBP) moiety. SLF binds non-covalently to FKBP12.
  • HY-163127
    AUTAC2-2G is a second-generation AUTAC with a 100-fold increase in activity.
  • HY-129652
    Halo PROTAC 1 2241668-45-9
    Halo PROTAC 1 is a conjugate of ligands for E3 and 22-atom-length linker. The connector of linker is Halogen group. Halo PROTAC 1 is a ligand having activity to bind to an intracellular proteins fused with HaloTag and a structure having activity to induce autophagy of an intracellular molecule are linked via a PEG linker. Halo PROTAC 1 can be uesd for the synthesis of AUTAC.
    Halo PROTAC 1
  • HY-150409
    TSPO ligand-2 1160640-95-8 99.63%
    TSPO ligand-2 is a ligand of AUTAC1. AUTAC1 contains an p-fluorobenzylguanine (FBnG) and a Fumagillol moiety, which can silence endogenous MetAP2 in HeLa cells.
    TSPO ligand-2
  • HY-147225
    TSPO Ligand-Linker Conjugates 1
    TSPO Ligand-Linker Conjugates 1 contains a ligand for translocator protein (TSPO) and a linker, which is used for the synthesis of mitochondria-targeting autophagy-targeting chimera (AUTAC). AUTAC can bind the TSPO on the outer mitochondrial membrane (OMM) of mitochondria and degrades impaired mitochondria and proteins via mitophagy, and improves mitochondrial activity. TSPO Ligand-Linker Conjugates 1 can be used in mitochondrial dysfunction related research, including neurodegenerative diseases, cancer, and diabetes.
    TSPO Ligand-Linker Conjugates 1
  • HY-150411
    Cys-C-cGMP 2241669-85-0
    Cys-C-cGMP is a autophagy tag for AUTACs. Cys-C-cGMP can increase the K63-linked ubiquitination of mitochondria in HeLa cells.
  • HY-150410
    TSPO ligand-3 2241669-89-4
    TSPO ligand-3 is a ligand of AUTAC2. AUTAC2 contains an p-fluorobenzylguanine (FBnG) and an synthetic ligand of FKBP (SLF) moiety, which can cause significant silencing of FKBP12 in HeLa cells.
    TSPO ligand-3