2. Signaling Pathways
  3. Epigenetics
  4. DNA Glycosylase

DNA Glycosylase

DNA Glycosylase

The base excision repair machinery protects DNA in cells from the damaging effects of oxidation, alkylation, and deamination; it is specialized to fix single-base damage in the form of small chemical modifications. DNA glycosylases play a key role in the elimination of such DNA lesions; they recognize and excise damaged bases, thereby initiating a repair process that restores the regular DNA structure with high accuracy. All glycosylases share a common mode of action for damage recognition; they flip bases out of the DNA helix into a selective active site pocket, the architecture of which permits a sensitive detection of even minor base irregularities. Accordingly, cells lacking DNA glycosylase functions generally show increased levels of base damage in their DNA, elevated mutation rates, and hypersensitivity to specific DNA damaging agents[1][2][3].

DNA Glycosylase Related Products (1):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-125276
    TH5487
    		Inhibitor 98.76%
    TH5487 is a potent 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC50 of 342 nM. TH5487 stops OGG1 from recognizing its DNA substrate, inhibits DNA repair and modifies OGG1 chromatin dynamics, which results in the inhibition of proinflammatory pathway genes.
    TH5487