DNA Glycosylase Inhibitor

DNA Glycosylase Inhibitor (1):

Cat. No.	Product Name	Effect	Purity

HY-125276

TH5487	Inhibitor	98.76%
TH5487 is a potent 8-oxoguanine DNA glycosylase 1 (OGG1) inhibitor with an IC₅₀ of 342 nM. TH5487 stops OGG1 from recognizing its DNA substrate, inhibits DNA repair and modifies OGG1 chromatin dynamics, which results in the inhibition of proinflammatory pathway genes.

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