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2024-04-26“ubiquitin-mediated protein degradation” won the Nobel Prize in Chemistry in 2004! In fact, proteasomes degrade not only ubiquitinated proteins but also non-ubiquitinated ones. The mechanism remains shrouded in mystery. After reading this piece today, you might have a lightbulb moment! -
2024-04-18SPR, which stands for Surface Plasmon Resonance, essentially works by detecting the interaction between ligands and analytes on a biosensor chip. This in turn allows us to probe the properties and structure of substances. With this technology, we can analyze molecules, proteins, DNA, and various organic and inorganic substances in samples in real-time with precision. -
2024-04-12Katalin Karikó and Drew Weissman were awarded the Nobel Prize in Physiology or Medicine in 2023 for their groundbreaking work in nucleoside modification, which paved the way for the creation of successful mRNA vaccines to fight against COVID-19. Let's now delve into the complete process of mRNA vaccine development.
- Anti-infection
- Antibody-drug Conjugate/ADC Related
- Apoptosis
- Autophagy
- Cell Cycle/DNA Damage
- Cytoskeleton
- Epigenetics
- GPCR/G Protein
- Immunology/Inflammation
- JAK/STAT Signaling
- MAPK/ERK Pathway
- Membrane Transporter/Ion Channel
- Metabolic Enzyme/Protease
- Neuronal Signaling
- NF-κB
- PI3K/Akt/mTOR
- PROTAC
- Protein Tyrosine Kinase/RTK
- Stem Cell/Wnt
- TGF-beta/Smad
- Vitamin D Related/Nuclear Receptor
- Others
Anti-infection
Cell Cycle/DNA Damage
Epigenetics
GPCR/G Protein
Immunology/Inflammation
Membrane Transporter/Ion Channel
Metabolic Enzyme/Protease
- 11β-HSD
- 15-PGDH
- 17β-HSD
- 5 alpha Reductase
- Acetolactate Synthase (ALS)
- Acetyl-CoA Carboxylase
- Acyltransferase
- ADAMTS
- Adiponectin Receptor
- Aldehyde Dehydrogenase (ALDH)
- Aldose Reductase
- Aminoacyl-tRNA Synthetase
- Aminopeptidase
- Amylases
- Angiotensin-converting Enzyme (ACE)
- Arginase
- ATGL
- ATP Citrate Lyase
- Carbonic Anhydrase
- Carboxypeptidase
Neuronal Signaling
Protein Tyrosine Kinase/RTK
Stem Cell/Wnt
- Compound Screening Libraries
- Bioactive Screening Libraries
- •Bioactive Compound Library
- Drug Repurposing Series
- •FDA-Approved Drug Library
- •Drug Repurposing Compound Library
- Natural Products Series
- •Natural Product Library
- •Natural Product-like Compound Library
- Metabolism Series
- •Human Endogenous Metabolite Compound Library
- Disease Related Compound Libraries
- Signaling Pathway Series
- Fragment Libraries
- Diversity Compound Libraries
- •50K Diversity Library
- •5K Scaffold Library
- •3D Diverse Fragment Library
- Virtual Screening
- •50K Virtual Diversity Library
- •10M Virtual Diversity Library
- Recombinant Proteins
- Cytokines and Growth Factors
- Immune Checkpoint Proteins
- CAR-T Related Proteins
- CD Antigens
- Fc Receptors
- Receptor Proteins
- Enzymes & Regulators
- Complement System
- Ubiquitin Related Proteins
- Viral Proteins
- Biotinylated Proteins
- Fluorescent-labeled Proteins
- GMP-grade Proteins
- Animal-free Recombinant Proteins
- Protein Expression Service
- Custom Synthesis Service
- ADC-Related Custom Services
- PROTAC-Related Custom Services
- Cytokines and Growth Factors
- Immune Checkpoint Proteins
- CAR-T Related Proteins
- CD Antigens
- Fc Receptors
- Receptor Proteins
- Enzymes & Regulators
- Complement System
- Ubiquitin Related Proteins
- Viral Proteins
- Biotinylated Proteins
- Fluorescent-labeled Proteins
- GMP-grade Proteins
- Animal-free Recombinant Proteins
- Others
- View More
CAR-T Related Proteins
- CD4
- CD19
- CD123
- CD138/Syndecan-1
- Epithelial Cell Adhesion Molecule (EpCAM)
- Folate Receptor 1
- GPC-3
- Guanylate Cyclase 2C
- ErbB2/HER2
- ErbB3/HER3
- c-Met/HGFR
- MSLN
- CA-125
- ROR1
- CEACAM-5
- Natural Killer Group 2, Member D (NKG2D)
- Prostate Specific Membrane Antigen
- CRACC/SLAMF7
- TROP-2
- Siglec-6
- Folate Receptor alpha (FR-alpha)
- CD7
- MUC-1/CD227
CD Antigens
- T Cell CD Proteins
- B Cell CD Proteins
- NK Cell CD Proteins
- Macrophage CD Proteins
- Monocyte CD Proteins
- Stem Cell CD Proteins
- Platelet CD Proteins
- Erythrocyte CD Proteins
- Dendritic Cell CD Proteins
- Epithelial cell CD Proteins
- Endothelial cell CD Proteins
- Signal Transduction-related CD Proteins
- Cell Adhesion-related CD Proteins
Receptor Proteins
- Receptor Tyrosine Kinases
- Receptor Serine/Threonine Kinases
- Receptor Tyrosine Phosphatase
- Receptor Guanylyl Cyclase Family
- Cell Adhesion Molecules (CAMs)
- G-Protein-Coupled Receptors (GPCRs)
- Nuclear Receptor Superfamily
- Pattern Recognition Receptors
- Notch family
- Siglec
- Leukocyte Immunoglobin-like Receptors
- Killer-Cell Immunoglobulin-like Receptors
- Cytokine Receptors
Enzymes & Regulators
- Oxidoreductases (EC 1)
- Transferases (EC 2)
- Hydrolases (EC 3)
- Lyases (EC 4)
- Isomerases (EC 5)
- Ligases (EC 6)
- Translocases (EC 7)
- Matrix Metalloproteinases
- ADAMs/ADAMTSs
- Cathepsin
- Carboxypeptidase
- Angiotensin-converting Enzymes
- Caspase
- Carbonic Anhydrase
- Serine/Threonine Kinase Proteins
- Protein Tyrosine Kinases
- Phosphatase
- Topoisomerase
- Protease Inhibitors
- Protein Kinase Inhibitor Peptide (PKI)
- Cyclin-Dependent Kinase Inhibitor Proteins
- Cystatin Family
- Molecular Biology
- •Nucleic Acid Gel Electrophoresis
- •Vector Construction
- •Nucleic acid extraction and purification
- •Restriction Endonuclease
- •Materials
- •PCR & qPCR
- •RT-PCR
- •Sequencing
- Protein Biology
- •Protein Sample Preparation
- •Protein Purification
- •Protein Electrophoresis & WB
- Cell Biology
- •Cell Culture
- •Cell Analysis
- •3D Cell Culture
- •Cell Isolation
- View More
- Custom Synthesis Service
- Bulk and Custom Synthesis Service
- ADC-Related Custom Services
- PROTAC-Related Custom Services
- Custom Reference Standard Products
- Custom Peptide Synthesis
- Protein Expression Service
- Protein Crystal Structure Elucidation
- Oligonucleotide Synthesis
- Fluorescent labeling Service
- Custom Synthesis of Stable Isotope-Labeled Compounds
- One-stop CDMO Service
- One-stop Compound Screening Platform
- Virtual Screening
- Molecular dynamics simulation
- Cell-based Compound Screening
- Ion Channel Screening
- Kinase Screening Service
- SPR Assay Service
- GPCR Bioassay Screening Services
- Nuclear Receptor Screening Services
- Affinity Mass Spectrometry
- DEL Synthesis and Screening
- Molarity Calculator
- Dilution Calculator
