2. Signaling Pathways
  3. Stem Cell/Wnt
  4. sFRP-1

sFRP-1

Secreted frizzled related protein 1; SARP-2; FrzA

sFRP-1

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Secreted frizzled-related proteins (SFRPs) are soluble proteins that have highly restricted tissue distribution. SFRPs are capable of binding to Wnts and frizzled (Fz) receptors to interfere with Wnt signaling, which plays a major role in cell fate determination through the regulation of cell proliferation, differentiation, and apoptosis.

sFRP-1 contributes to the inhibition of apoptosis in fibroblast populations. sFRP-1 proteins are involved in apoptosis by negatively modulating wingless/int (WNT) signaling by interacting with either WNTs or Frizzled receptors. By sequestering WNTs, sFRP-1 removes the stimulus for β-catenin stabilization and mediates various biological processes.

SFRP proteins modulate Wnt signalling by interacting with either Wnt or frizzled receptors and are reported to affect epithelial/stromal interactions in prostate cancer.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-10858
    WAY 316606
    		Inhibitor 99.24%
    WAY 316606 is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. The affinity of WAY-316606 for sFRP-1 is determined using the FP binding assay with IC50 of 0.5 μM.
    WAY 316606
  • HY-10858A
    WAY 316606 hydrochloride
    		Inhibitor
    WAY 316606 hydrochloride is an inhibitor of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt. The affinity of WAY-316606 for sFRP-1 is determined using the FP binding assay with IC50 of 0.5 μM.
    WAY 316606 hydrochloride
  • HY-10860
    WAY-362692
    		Inhibitor
    WAY-362692 is a secreted frizzled-related protein (sFRP-1) inhibitor (IC50 of 0.02 μM), targeting the netrin domain of sFRP-1. WAY-362692 can competitively inhibit the interaction between sFRP-1 and Wnt proteins, and activate the Wnt/β-catenin signaling pathway (EC50 = 0.03 μM). WAY-362692 can activate osteoblasts and promote bone remodeling. WAY-362692 can be used for the research of metabolic disease, such as osteoporosis.
    WAY-362692
Cat. No. Product Name / Synonyms Application Reactivity