Advance Your Research with Year-End Savings

Discover greater value with MedChemExpress (MCE): enjoy exclusive discounts on products and services, plus free standard shipping on every order (excludes free-sample-only and dry ice shipments).

Maximize your savings and accelerate breakthrough research today.

Promotion Period：September 1 to December 31, 2025
30% off Ready-to-Use Compound Libraries
20% off Peptides / Recombinant Proteins / Biochemical Assay Reagents / Dye Reagents / Antibodies / Kits
10% off Bulk Size Products / Custom Synthesis Services

•

Compound Screening Libraries
(26,000+ Bioactive Compounds / 80,000+ Lead-like Diversity Compounds)

• 10M MegaUni Virtual Diversity Compounds
• Molecular Interaction Assay Service (SPR, MST, BLI, ITC)
• Target-based Drug Screening (Kinase, GPCR, ion channel, nuclear receptor)
• Phenotype-based Drug Screening
• DEL Synthesis and Screening
• Drug Target Identification Service
• Lead Compound Optimization
• 200+ compound libraries
• 26,000+ in stock bioactive compounds with known targets
• Covering latest-reported molecules
• Cherry-picked Library: specific compounds, quantities, plate map, concentration, form (solid or solution)…
• Suitable for drug repurposing, target mechanism analysis, development of compound functions, omics research, and so on.
• 8,000+ Peptide Products: covering popular targets such as GLP-1R, AMTR, β-Amyloid, ion channels, PI3K, and more.
• Strict Quality Control: each product is tested by MS and HPLC to ensure high purity and reliability.
Biochemical Assay Reagents are essential tools for life science research and clinical diagnostics, covering a wide range of biological materials and organic compounds. MCE offers a comprehensive portfolio of reagents, including co-solvents, enzymes, enzyme substrates, cell assay reagents, and indicators. Designed to meet diverse experimental needs, MedChemExpress's reagents deliver robust performance and reliable results.

• 13,000+ products: including cytokines, target proteins, and enzymes, designed to meet the highest standards.

• Superior Purity: ＞ 95%
• Outstanding Bioactivity
• Excellent Lot-to-Lot Consistency
• Low Endotoxin Levels: <1 EU/μg
• Flexible Package Size: from 2 μg to 1 mg
Scientific Data

Purity: The purity of human IL-17F protein (HY-P70540) is greater than 95%, as determined by reducing SDS-PAGE analysis.

Bioactivity: Measured by human IL-17F protein’s (HY-P70540) ability to induce IL-6 secretion in NIH‑3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 12.46 ng/mL, corresponding to a specific activity is 8.026×104 U/mg.

Binding Affinity: When loaded on an NTA biosensor, human IL-17F protein (HY-P70540) binds Sonelokimab (HY-P99397) with an affinity constant of 2.859 × 10-10 M, as determined in BLI assay.

Customer Validation

In the MMP-9 (HY-P73807) treated group, anti-VEGF antibody(aV) release was higher than in controls. Addition of an MMP-9 inhibitor reduced aV release, indicating that MMP-9 specifically cleaves the peptide chain to release aV.
(Cited in: ACS Nano. 2024 Aug 20;18(33):22194-22207).

MCE offers 7,000+ premium primary antibodies and a wide range of high-quality secondary antibodies. The collection covers key signaling pathways such as autophagy, apoptosis, immunity, and cell cycle regulation, addressing a broad spectrum of popular targets to support research with confidence and efficiency.

• High Specificity and Affinity: recombinant monoclonal antibodies.
• Wide Applicability: suitable for WB, IF/ICC, IHC, FC, ELISA, etc.
• Rigorous Quality Control: each antibody batch undergoes rigorous testing to ensure consistent, reliable performance.
Scientific Data

Immunofluorescence analysis of RAB7 in NIH3T3 cells.
PAb: RAB7 Antibody (HY-P80295)
SAb: Alexa Fluor® 488-conjugated AffiniPure Goat Anti-Rabbit IgG H&L (HY-P8002)

Immunohistochemical analysis of ATF4 on paraffin-embedded rat colon tissue.
PAb: ATF4 Antibody (YA605) (HY-P80486)
SAb: HRP-conjugated AffiniPure Goat Anti-Rabbi IgG (H+L) (HY-P8001)

PAb: Hsp90 beta Antibody (HY-P80187)
SAb: HRP-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L) (HY-P8001)
Internal Reference: GAPDH Antibody (HRP) (HY-P80954A)

Customer Validation

Co-staining of SIRT1 (green,HY-P80319) and Iba1 (red) demonstrated that SIRT1 was upregulated in microglia 24 h after SAH.
(Cited in: J Inflamm Res. 2024 Mar 28:17:1971-1981.)

•

MCE offers 3,000+ high-quality fluorescent dye probes featuring high sensitivity, stability, and fluorescence intensity, helping ensure reliable results across a broad range of research needs.

•

Fluorescent dyes absorb specific wavelengths of light and emit longer wavelengths, enabling the characterization, localization, and quantification of target molecules through covalent binding or physical adsorption. Widely used in pharmacology, physiology, environmental science, and protein research, these dyes support diverse scientific application.

Customer Validation

Researchers evaluated the protective effects of Ru/def-Cu(OH)2 on cell survival under oxidative stress using live/dead fluorescence staining and the DCFH-DA probe (HY-D0940). The results showed that Ru/def-Cu(OH)2 significantly reduced the number of dead cells across various cell types exposed to H2O2.
(Cited in: Adv Mater. 2024 Nov;36(48):e2411618.)

MCE offers a broad range of high-quality, cost-effective, ready-to-use assay kits for the convenient and dependable analysis of molecular, protein, cell biology research.

•

Molecular Biology Kits: designed for cloning and genetic profiling, includes essentials like qPCR master mixes and restriction enzymes.

•

Protein Biology Kits: optimized for protein purification and analysis, features products such as protease inhibitor cocktails and magnetic beads.

•

Cell Biology Kits: tailored for cell culture and viability studies.

Customer Validation

HY-K0201 Anti-HA Magnetic Beads
Co-IP detection of HA-tagged protein expression in HepG2 cells.
(Nat Commun. 2024 Mar 8;15 (1) :1908.)

MCE offers 11,000+ high quality isotope-labeled compounds, which are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes.

• Compound Types: include inhibitors, vitamins, amino acids, metabolites, and others.
• Labeled Options: 2H (D), 13C, 15N, 17O/18O, and more.
• Quantitative Accuracy: reach up to PPM level.
• Longer Tracing Time: not limited by half-life.
Cat. No Names Category
HY-10201S Sorafenib-d3 Isotope-labeled Inhibitors
HY-13631AS Exatecan-d5 mesylate
HY-B0389A D-Glucose-13C6 Isotope-labeled Metabolites
HY-N0390S1 L-Glutamine-13C6
HY-I1124 L-Valine-d8 Isotope-labeled Amino Acids
HY-N0486S1 L-Leucine-13C
HY-N1446S1 Oleic acid-d2 Isotope-labeled Lipids
HY-N0830S3 Palmitic acid-1-13C
HY-B0617S S-Adenosyl-L-methionine-d3 Isotope-labeled Nucleic Acids
HY-113139S 1-Methylinosine-d3

MCE offers 8,000+ high-quality reference standards, each accompanied by detailed analytical documentation verifying structure, purity, and quantity in accordance with ISO 17025 standards.

• Broad Categories: covering fields such as biology, medicine, food and environmentcal science.
• Full Range of Sizes: available in various pre-packaged options.
• Rigorous Quality Testing: NMR, MS, KF, LOD, TGA and qNMR, with measurement traceability support.
Cat. No Names Category
HY-16561R Resveratrol (Standard) Natural Product Standards
HY-14649R Retinoic acid (Standard) Cosmetic Testing Standards
HY-B1103R Hydroxyhexamide (Standard) Drug Metabolite Standards
HY-13582R Carbendazim (Standard) Pesticide Standards
HY-B0196R Venlafaxine (Standard) Pharmacuetical Impurity Standards
HY-13757AR Tamoxifen (Standard) Pharmacuetical Components Standards
HY-B0166R L-Ascorbic acid (Standard) Human Metabolite Standards

•

29,000+ Pre-Designed siRNA Set: each set contains 3 siRNAs for target gene (human, mouse, or rat), a negative control, a positive control, and a FAM-labeled negative control. We guarantee that when the transfection efficiency exceeds 80%, at least one siRNA will achieve 70% target mRNA silencing; otherwise, we will synthesize 3 new siRNAs free of charge.

Component Quantity Description
siRNA-1 5 nmoL Three different siRNAs are designed for different regions of the target gene.
siRNA-2
siRNA-3
siRNA Negative Control 5 nmoL There is no homology between negative control sequence and the target gene sequence.
FAM-labeled siRNA
Negative Control		 5 nmoL It is used to detect the transfection efficiency.
GAPDH siRNA
Positive Control		 5 nmoL It is used to confirm that the RNAi experiments were performed correctly.

•

18,000+ miRNA Tools: including miRNA mimics, inhibitors, agomirs, and antagomirs, developed based on mature miRNA sequences from the miRBase database, for studying miRNA function.

Category Characteristic Description
miRNA mimic Mimics endogenous miRNA Transfection reagents are required. Suitable for cellular experiments.
miRNA inhibitor Inhibits miRNA function
miRNA agomir Mimics endogenous miRNA Using special chemical modification and end labeling techniques. Suitable for animal experiments.
miRNA antagomir Inhibits miRNA function
Please Note
1. This promotion is exclusively available in Europe (including the UK).
2. Free shipping can be combined with discounts and is only available to end customers.
3. For inquiries, please contact us at eu.sales@medchemexpress.com.
4. MCE reserves the right of final interpretation.
Advance Your Research with Year-End Savings

Discover greater value with MedChemExpress (MCE): enjoy exclusive discounts products and services.
Maximize your savings and accelerate breakthrough research today

Promotion Period：September 1 to December 31, 2025
25% off Ready-to-Use Compound Libraries
20% off Isotope-labeled compounds / Reference Standards / siRNAs / miRNAs
Peptides / Recombinant Proteins / Biochemical Assay Reagents / Antibodies / Dye Reagents / Kits
10% off Bulk Size Products / Custom Synthesis Services

•

Compound Screening Libraries
(26,000+ Bioactive Compounds / 80,000+ Lead-like Diversity Compounds)

• 10M MegaUni Virtual Diversity Compounds
• Molecular Interaction Assay Service (SPR, MST, BLI, ITC)
• Target-based Drug Screening (Kinase, GPCR, ion channel, nuclear receptor)
• Phenotype-based Drug Screening
• DEL Synthesis and Screening
• Drug Target Identification Service
• Lead Compound Optimization
• 200+ compound libraries
• 26,000+ in stock bioactive compounds with known targets
• Covering latest-reported molecules
• Cherry-picked Library: specific compounds, quantities, plate map, concentration, form (solid or solution)…
• Suitable for drug repurposing, target mechanism analysis, development of compound functions, omics research, and more.
• 8,000+ Peptide Products: covering popular targets such as GLP-1R, AMTR, β-Amyloid, ion channels, PI3K, and more.
• Strict Quality Control: each product is tested by MS and HPLC to ensure high purity and reliability.
Biochemical Assay Reagents are essential tools for life science research and clinical diagnostics, covering a wide range of biological materials and organic compounds. MCE offers a comprehensive portfolio of reagents, including co-solvents, enzymes, enzyme substrates, cell assay reagents, and indicators. Designed to meet diverse experimental needs, MCE's reagents deliver robust performance and reliable results.

• 13,000+ products: including cytokines, target proteins, and enzymes, designed to meet the highest standards.

• Superior Purity: ＞ 95%
• Outstanding Bioactivity
• Excellent Lot-to-Lot Consistency
• Low Endotoxin Levels: <1 EU/μg
• Flexible Package Size: from 2 μg to 1 mg
Scientific Data

Purity: The purity of human IL-17F protein (HY-P70540) is greater than 95%, as determined by reducing SDS-PAGE analysis.

Bioactivity: Measured by human IL-17F protein’s (HY-P70540) ability to induce IL-6 secretion in NIH‑3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 12.46 ng/mL, corresponding to a specific activity is 8.026×104 U/mg.

Binding Affinity: When loaded on an NTA biosensor, human IL-17F protein (HY-P70540) binds Sonelokimab (HY-P99397) with an affinity constant of 2.859 × 10-10 M, as determined in BLI assay.

Customer Validation

In the MMP-9 (HY-P73807) treated group, anti-VEGF antibody(aV) release was higher than in controls. Addition of an MMP-9 inhibitor reduced aV release, indicating that MMP-9 specifically cleaves the peptide chain to release aV.
(Cited in: ACS Nano. 2024 Aug 20;18(33):22194-22207).

MCE offers 7,000+ premium primary antibodies and a wide range of high-quality secondary antibodies. The collection covers key signaling pathways such as autophagy, apoptosis, immunity, and cell cycle regulation, addressing a broad spectrum of popular targets to support research with confidence and efficiency.

• High Specificity and Affinity: recombinant monoclonal antibodies.
• Wide Applicability: suitable for WB, IF/ICC, IHC, FC, ELISA, etc.
• Rigorous Quality Control: each antibody batch undergoes rigorous testing to ensure consistent, reliable performance.
Scientific Data

Immunofluorescence analysis of RAB7 in NIH3T3 cells.
PAb: RAB7 Antibody (HY-P80295)
SAb: Alexa Fluor® 488-conjugated AffiniPure Goat Anti-Rabbit IgG H&L (HY-P8002)

Immunohistochemical analysis of ATF4 on paraffin-embedded rat colon tissue.
PAb: ATF4 Antibody (YA605) (HY-P80486)
SAb: HRP-conjugated AffiniPure Goat Anti-Rabbi IgG (H+L) (HY-P8001)

PAb: Hsp90 beta Antibody (HY-P80187)
SAb: HRP-conjugated AffiniPure Goat Anti-Rabbit IgG (H+L) (HY-P8001)
Internal Reference: GAPDH Antibody (HRP) (HY-P80954A)

Customer Validation

Co-staining of SIRT1 (green,HY-P80319) and Iba1 (red) demonstrated that SIRT1 was upregulated in microglia 24 h after SAH.
(Cited in: J Inflamm Res. 2024 Mar 28:17:1971-1981.)

•

MCE offers 3,000+ high-quality fluorescent dye probes featuring high sensitivity, stability, and fluorescence intensity, helping ensure reliable results across a broad range of research needs.

•

Fluorescent dyes absorb specific wavelengths of light and emit longer wavelengths, enabling the characterization, localization, and quantification of target molecules through covalent binding or physical adsorption. Widely used in pharmacology, physiology, environmental science, and protein research, these dyes support diverse scientific application.

Customer Validation

Researchers evaluated the protective effects of Ru/def-Cu(OH)2 on cell survival under oxidative stress using live/dead fluorescence staining and the DCFH-DA probe (HY-D0940). The results showed that Ru/def-Cu(OH)2 significantly reduced the number of dead cells across various cell types exposed to H2O2.
(Cited in: Adv Mater. 2024 Nov;36(48):e2411618.)

MCE offers a broad range of high-quality, cost-effective, ready-to-use assay kits for the convenient and dependable analysis of molecular, protein, cell biology research.

•

Molecular Biology Kits: designed for cloning and genetic profiling, includes essentials like qPCR master mixes and restriction enzymes.

•

Protein Biology Kits: optimized for protein purification and analysis, features products such as protease inhibitor cocktails and magnetic beads.

•

Cell Biology Kits: tailored for cell culture and viability studies.

Customer Validation

HY-K0201 Anti-HA Magnetic Beads
Co-IP detection of HA-tagged protein expression in HepG2 cells.
(Nat Commun. 2024 Mar 8;15 (1) :1908.)

MCE offers 11,000+ high quality isotope-labeled compounds, which are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes.

• Compound Types: include inhibitors, vitamins, amino acids, metabolites, and others.
• Labeled Options: 2H (D), 13C, 15N, 17O/18O, and more.
• Quantitative Accuracy: reach up to PPM level.
• Longer Tracing Time: not limited by half-life.
Cat. No Names Category
HY-10201S Sorafenib-d3 Isotope-labeled Inhibitors
HY-13631AS Exatecan-d5 mesylate
HY-B0389A D-Glucose-13C6 Isotope-labeled Metabolites
HY-N0390S1 L-Glutamine-13C6
HY-I1124 L-Valine-d8 Isotope-labeled Amino Acids
HY-N0486S1 L-Leucine-13C
HY-N1446S1 Oleic acid-d2 Isotope-labeled Lipids
HY-N0830S3 Palmitic acid-1-13C
HY-B0617S S-Adenosyl-L-methionine-d3 Isotope-labeled Nucleic Acids
HY-113139S 1-Methylinosine-d3

MCE offers 8,000+ high-quality reference standards, each accompanied by detailed analytical documentation verifying structure, purity, and quantity in accordance with ISO 17025 standards.

• Broad Categories: covering fields such as biology, medicine, food and environmentcal science.
• Full Range of Sizes: available in various pre-packaged options.
• Rigorous Quality Testing: NMR, MS, KF, LOD, TGA and qNMR, with measurement traceability support.
Cat. No Names Category
HY-16561R Resveratrol (Standard) Natural Product Standards
HY-14649R Retinoic acid (Standard) Cosmetic Testing Standards
HY-B1103R Hydroxyhexamide (Standard) Drug Metabolite Standards
HY-13582R Carbendazim (Standard) Pesticide Standards
HY-B0196R Venlafaxine (Standard) Pharmacuetical Impurity Standards
HY-13757AR Tamoxifen (Standard) Pharmacuetical Components Standards
HY-B0166R L-Ascorbic acid (Standard) Human Metabolite Standards

•

29,000+ Pre-Designed siRNA Set: each set contains 3 siRNAs for target gene (human, mouse, or rat), a negative control, a positive control, and a FAM-labeled negative control. We guarantee that when the transfection efficiency exceeds 80%, at least one siRNA will achieve 70% target mRNA silencing; otherwise, we will synthesize 3 new siRNAs free of charge.

Component Quantity Description
siRNA-1 5 nmoL Three different siRNAs are designed for different regions of the target gene.
siRNA-2
siRNA-3
siRNA Negative Control 5 nmoL There is no homology between negative control sequence and the target gene sequence.
FAM-labeled siRNA
Negative Control		 5 nmoL It is used to detect the transfection efficiency.
GAPDH siRNA
Positive Control		 5 nmoL It is used to confirm that the RNAi experiments were performed correctly.

•

18,000+ miRNA Tools: including miRNA mimics, inhibitors, agomirs, and antagomirs, developed based on mature miRNA sequences from the miRBase database, for studying miRNA function.

Category Characteristic Description
miRNA mimic Mimics endogenous miRNA Transfection reagents are required. Suitable for cellular experiments.
miRNA inhibitor Inhibits miRNA function
miRNA agomir Mimics endogenous miRNA Using special chemical modification and end labeling techniques. Suitable for animal experiments.
miRNA antagomir Inhibits miRNA function
Please Note
1. This promotion is exclusively available in the following regions: Singapore, Malaysia, Indonesia, Australia, New Zealand, India, Thailand.
2. This offer cannot be combined with other promotions and is valid for end users only.
3. MCE reserves the right of final interpretation.
4. For inquiries, contact us at sales@medchemexpress.cn (India: in.sales@medchemexpress.com).