2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
  4. Glycine Receptor (GlyR)

Glycine Receptor (GlyR)

Glycine Receptor

Glycine Receptor (GlyR) is a ligand-gated chloride ion channel. GlyR can specifically bind to the neurotransmitter glycine, mediate the influx of chloride ions, thereby generating inhibitory postsynaptic potentials and regulating the excitability of neurons. GlyR can be activated by a series of simple amino acids, such as glycine, alanine, and taurine. GlyR is involved in various physiological functions such as sensory information processing, motor control, pain perception, and cognition, and plays a crucial role in the process of neural signal transmission. Abnormal functions of GlyR are associated with multiple neurodevelopment-related disorders, such as autism and epilepsy[1].

Glycine Receptor (GlyR) Related Products (1):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-106969A
    ZD 9379 sodium
    		Antagonist
    ZD 9379 sodium is a competitive glycine/NMDA receptor antagonist, with an IC50 value of 75 nM (glutamate site). ZD 9379 sodium selectively antagonizes the glycine binding site (GlyB site) on the NMDA receptor, inhibiting the binding of glycine to the NMDA receptor and alleviating excitotoxicity. ZD 9379 sodium reduces the frequency of cortical spreading depression (SDs), alleviates energy depletion in the ischemic penumbra, and delays the expansion of infarction. ZD 9379 sodium reduces the infarct volume and improves neurological function in mouse models. ZD 9379 sodium can be used in studies of acute ischemic stroke, etc.
    ZD 9379 sodium