2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Glycine Receptor (GlyR) iGluR
  4. ZD 9379 sodium

ZD 9379 sodium is a competitive glycine/NMDA receptor antagonist, with an IC50 value of 75 nM (glutamate site). ZD 9379 sodium selectively antagonizes the glycine binding site (GlyB site) on the NMDA receptor, inhibiting the binding of glycine to the NMDA receptor and alleviating excitotoxicity. ZD 9379 sodium reduces the frequency of cortical spreading depression (SDs), alleviates energy depletion in the ischemic penumbra, and delays the expansion of infarction. ZD 9379 sodium reduces the infarct volume and improves neurological function in mouse models. ZD 9379 sodium can be used in studies of acute ischemic stroke, etc.

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ZD 9379 sodium

ZD 9379 sodium Chemical Structure

CAS No. : 170142-29-7

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Description

ZD 9379 sodium is a competitive glycine/NMDA receptor antagonist, with an IC50 value of 75 nM (glutamate site). ZD 9379 sodium selectively antagonizes the glycine binding site (GlyB site) on the NMDA receptor, inhibiting the binding of glycine to the NMDA receptor and alleviating excitotoxicity. ZD 9379 sodium reduces the frequency of cortical spreading depression (SDs), alleviates energy depletion in the ischemic penumbra, and delays the expansion of infarction. ZD 9379 sodium reduces the infarct volume and improves neurological function in mouse models. ZD 9379 sodium can be used in studies of acute ischemic stroke, etc[1][2].

In Vivo

ZD 9379 (5 mg/kg, i.v., for 4 hours) sodium significantly reduces the infarct volume in the rat model of permanent middle cerebral artery occlusion (MCAO), inhibits SDs, and improves neurological function[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MCAO model established in male Sprague-Dawley rats (weighing 290-340 grams)[1]
Dosage: 5 mg/kg
Administration: Intravenous injection (i.v.), for 4 hours
Result: Significantly reduced infarction volume, and the number of SDs was significantly decreased.
Significantly improved neurological scores, without causing significant changes in physiological parameters or behavioral side effects.
Molecular Weight

406.77

Formula

C19H15ClN3NaO4
CAS No.
SMILES

O=C1C2=C(C(NN1C3=C(C=C(OC)C=C3)C)=O)NC4=C(C=CC(Cl)=C4)C2=O.[Na]
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Purity & Documentation
References
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ZD 9379 sodium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZD 9379170142-29-7ZD9379ZD-9379Glycine Receptor (GlyR)iGluRGlycine ReceptorIonotropic glutamate receptorscerebral ischemiamiddle cerebral artery occlusionN-methyl-D-aspartatespreading cortical depressionratsInhibitorinhibitorinhibit

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