2. Metabolic Enzyme/Protease
  3. 3β-HSD
  4. Epostane

Epostane (WIN 32729) is an orally active inhibitor for 3β-hydroxysteroid dehydrogenase, with IC50 of 1.45 nM. Epostane blocks ovulation and pregnancy in rats.

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Epostane

Epostane Chemical Structure

CAS No. : 80471-63-2

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Based on 1 publication(s) in Google Scholar

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Description

Epostane (WIN 32729) is an orally active inhibitor for 3β-hydroxysteroid dehydrogenase, with IC50 of 1.45 nM. Epostane blocks ovulation and pregnancy in rats[1].

In Vivo

Epostane (0-200 mg/kg, p.o., single dose) inhibits ovulation in mature rats and gonadotropin-stimulated ovulation in immature rats, terminates pregnancy through lowering plasma progesterone levels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague Dawley rats model[1]
Dosage: 0-200 mg/kg
Administration: p.o., single dose
Result: Terminated ovulation and pregnancy in rats, which was reversed by injections of progesterone.
Molecular Weight

357.49

Formula

C22H31NO3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@@]3(CC[C@]4([H])[C@]2([H])CC[C@]5([C@@]4([H])CC[C@@]5(O)C)C)[C@](O3)(C(O)=C(C1)C#N)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Epostane Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Epostane80471-63-2WIN 32729WIN32729WIN-327293β-HSDSprague Dawley ratsprogesteroneInhibitorinhibitorinhibit

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