E-Cadherin Antibody (YA3775)

E-Cadherin Antibody (YA3775) is a mouse-derived and non-conjugated IgG1 antibody, targeting to CDH1. It can be applicated for WB, IHC-P, FC, ELISA assays, in the background of human, mouse, monkey.

Cadherins are calcium-dependent cell adhesion proteins that preferentially interact homophilically between connected cells, contributing to the sorting of heterogeneous cell types. CDH1 regulates epithelial cell-cell adhesion, mobility, and proliferation. By interacting with AMOTL2 (by similar), it organizes radial actin fiber structures and mediates cellular responses to contractile forces by anchoring these fibers to CDH1 junction complexes at the membrane. During early desmosome formation, CDH1 facilitates recruitment of DSG2 and DSP to desmosomal plaques. It acts as a potent invasion suppressor and serves as a ligand for integrin α-E/β-7. E-Cad/CTF2 promotes non-amyloidogenic processing of Aβ precursors and strongly inhibits APP C99/C83 production. Additionally (Microbial infection), CDH1 functions as a receptor for Listeria monocytogenes via binding of bacterial InlA to mediate internalization.

P12830

Predicted band size: 97 kDa; Observed band size: 135 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human, Mouse, Monkey

WB: 1/500-1/2000; IHC: 1/200-1/1000; FC: 1/200-1/400; ELISA: 1/10000

WB, IHC-P, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG1

Purified recombinant fragment of human CDH1 expressed in E. Coli.