2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Cell Cycle/DNA Damage
  3. FABP PPAR
  4. (E/Z)-ABP/PPAR modulator 1

(E/Z)-ABP/PPAR modulator 1 is a mixture of the E and Z isomers of ABP/PPAR modulator 1 (HY-172883). ABP/PPAR modulator 1 is an orally active FABP and PPAR multiple modulator (IC50s of 0.65  μM and 1.08  μM for FABP1 and FABP4, EC50 s of 9.19  μM, 2.20  μM and 1.58 μM for PPARα, PPARγ and PPARδ). ABP/PPAR modulator 1 has potent anti-metabolic dysfunction-associated steatohepatitis (MASH) activity. ABP/PPAR modulator 1 dose-dependently ameliorates multiple pathological characteristics of fatty liver in WD + Carbon tetrachloride-induced MASH mice model.

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(E/Z)-ABP/PPAR modulator 1

(E/Z)-ABP/PPAR modulator 1 Chemical Structure

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(E/Z)-ABP/PPAR modulator 1 Related Antibodies

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Description

(E/Z)-ABP/PPAR modulator 1 is a mixture of the E and Z isomers of ABP/PPAR modulator 1 (HY-172883). ABP/PPAR modulator 1 is an orally active FABP and PPAR multiple modulator (IC50s of 0.65  μM and 1.08  μM for FABP1 and FABP4, EC50 s of 9.19  μM, 2.20  μM and 1.58 μM for PPARα, PPARγ and PPARδ). ABP/PPAR modulator 1 has potent anti-metabolic dysfunction-associated steatohepatitis (MASH) activity. ABP/PPAR modulator 1 dose-dependently ameliorates multiple pathological characteristics of fatty liver in WD + Carbon tetrachloride-induced MASH mice model[1].

Molecular Weight

561.67

Formula

C33H39NO7
SMILES

COC1=CC=C(/C=C/C2=CC(OCC3=CC=C(OC(C)(C)C(N[C@@H](C(O)=O)CC(C)C)=O)C=C3)=CC(OC)=C2)C=C1
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Room temperature in continental US; may vary elsewhere.
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References
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(E/Z)-ABP/PPAR modulator 1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E/Z)-ABP/PPAR modulator 1FABPPPARFatty acid-binding proteinPeroxisome proliferator-activated receptorsMetabolic dysfunction-associated steatohepatitis (MASH)FABPsPPARsLipid metabolismOxidative stressFibrosisInflammationInhibitorinhibitorinhibit

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