2. Anti-infection
  3. Bacterial
  4. PA2-GNU7

PA2-GNU7 is an antimicrobial peptide (AMP). PA2-GNU7 exhibits potent antimicrobial activity with minimal inhibitory concentration (MIC) against P. aeruginosa, E. coli, S. typhimurium, S. aureus, and C. albicans are 2 μM, 1 μM, 2 μM, 2 μM, and 8 μM, respectively. PA2-GNU7 rapidly and selectively kills Pseudomonas aeruginosa without affecting other commensal bacteria. PA2-GNU7 significantly improves survival of mice infected with P. aeruginosa. PA2-GNU7 can be used for the research and development of therapeutic agents against MDR Pseudomonas aeruginosa infections.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

PA2-GNU7

PA2-GNU7 Chemical Structure

CAS No. : 2387505-19-1

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PA2-GNU7 Related Antibodies

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Description

PA2-GNU7 is an antimicrobial peptide (AMP). PA2-GNU7 exhibits potent antimicrobial activity with minimal inhibitory concentration (MIC) against P. aeruginosa, E. coli, S. typhimurium, S. aureus, and C. albicans are 2 μM, 1 μM, 2 μM, 2 μM, and 8 μM, respectively. PA2-GNU7 rapidly and selectively kills Pseudomonas aeruginosa without affecting other commensal bacteria. PA2-GNU7 significantly improves survival of mice infected with P. aeruginosa. PA2-GNU7 can be used for the research and development of therapeutic agents against MDR Pseudomonas aeruginosa infections[1].

In Vitro

PA2-GNU7 (21 h) exhibits potent antimicrobial activity with minimal inhibitory concentration (MIC) against P. aeruginosa, E. coli, S. typhimurium, S. aureus, and C. albicans are 2 μM, 1 μM, 2 μM, 2 μM, and 8 μM, respectively[1].
PA2-GNU7 (1 μM) selectively kills P. aeruginosa in dual-species cultures (1:1 P. aeruginosa with E. coli or S. typhimurium)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PA2-GNU7 Related Antibodies
In Vivo

PA2-GNU7 (15-25 mg/kg, intraperitoneal injection, 30 min post-infection) significantly improves survival of BALB/c mice infected with P. aeruginosa[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice (6-8 weeks old, female) infected with 2×107 CFU MDR P. aeruginosa[1]
Dosage: 15 mg/kg or 25 mg/kg
Administration: Intraperitoneal injection 30 min post-infection
Result: Achieved significantly improved survival rates.
Reduced bacterial loads in the liver, kidney, and spleen.
Molecular Weight

3372.11

Formula

C150H276N50O37
CAS No.
Sequence

Ser-Gln-Arg-Lys-Leu-Ala-Ala-Lys-Leu-Thr-Ser-Lys-Gly-Gly-Gly-Arg-Leu-Leu-Arg-Pro-Leu-Leu-Gln-Leu-Leu-Lys-Gln-Lys-Leu-Arg
Sequence Shortening

SQRKLAAKLTSKGGGRLLRPLLQLLKQKLR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PA2-GNU7 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PA2-GNU72387505-19-1BacterialAntimicrobial peptideHybrid peptideMultidrug-resistant Pseudomonas aeruginosaOprFSelective antimicrobial activityInhibitorinhibitorinhibit

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