2. Peptides
  3. Peptide and Derivatives
  4. Antimicrobial Peptides

Antimicrobial Peptides

Custom Peptide Synthesis

Antimicrobial peptides (AMPs) are a class of small peptides that play a pivotal role in host innate immunity, primarily exhibiting broad-spectrum activity against bacteria, fungi, and viruses, and in many cases also demonstrating anti-parasitic and anti-tumor effects.

Antimicrobial Peptides (586):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P1222
    LL-37, human 154947-66-7 99.60%
    LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human could help protect the cornea from infection and modulates wound healing.
    LL-37, human
  • HY-A0248
    Polymyxin B Sulfate 1405-20-5
    Polymyxin B Sulfate is a potent antibacterial agent and a relatively toxic antibiotic. Polymyxin B Sulfate also is a antiendotoxin agent. Polymyxin B Sulfate shows endotoxin-neutralizing properties can be used as adjunctive research in gram-negative sepsis. Polymyxin B Sulfate shows antibacterial activities in vitro and in vivo.
    Polymyxin B Sulfate
  • HY-B0108
    Daptomycin 103060-53-3 99.73%
    Daptomycin is a lipopeptide antibiotic with rapid in vitro bactericidal activity against gram-positive organisms.
    Daptomycin
  • HY-B0990
    Thiostrepton 1393-48-2 99.80%
    Thiostrepton is a thiazole antibiotic which selectively inhibits FOXM1. FOXM1 binds to YAP/TEAD complex. YAP/TEAD/FOXM1 complex binding at regulatory regions of genes governing cell cycle may impact cell proliferation.
    Thiostrepton
  • HY-P0233
    Melittin 20449-79-0 99.78%
    Melittin is a PLA2 activator, stimulates the activity of the low molecular weight PLA2, while it does not the increase activity of the high molecular weight PLA2.
    Melittin
  • HY-P3361A
    IDR-1018 acetate 99.57%
    IDR-1018 acetate is an innate defense regulator conjugate, with MICs of 16 μg/mL for MRSA USA300 LAC, MRSA SAP 0017 and S. epidermidis ATCC14990. IDR-1018 acetate can be used to synthesis V-IDR1018 (vancomycin-innate defense regulator conjugate).
    IDR-1018 acetate
  • HY-P6172
    GCO-(GPO)10-GCOG
    GCO-(GPO)10-GCOG is a GPO repeat-containing peptide with a single collagen triple helix structure similar to collagen. The cross-linked triple helix GCO-(GPO)10-GCOG can form a collagen-related peptide (CRP) mimetic that tightly binds to the Yersinia adhesin YadA. YadA mediates the adhesion of the human enteric pathogen Yersinia enterocolitica to collagen and other extracellular matrix components, potentially interfering with host processes mediated by endogenous collagen-binding proteins in vivo. GCO-(GPO)10-GCOG can be used to study YadA-associated infections.
    GCO-(GPO)10-GCOG
  • HY-P11012
    EK1
    EK1 is a peptide-based fusion inhibitor of coronaviruses (CoVs) with broad spectrum inhibition to a number of CoV species. EK1 shows substantially improved pan-CoV fusion inhibitory activity. EK1 potently inhibits SARS-CoV-2. EK1 can form a stable six-helix bundle (6HB) structure with both short α-hCoV and long β-hCoV N-terminal heptad repeats.
    EK1
  • HY-P1607
    Nisin 1414-45-5
    Nisin is a bacteriocin produced by a group of Gram-positive bacteria that belongs to Lactococcus and Streptococcus species. Nisin has antibacterial and anti-inflammatory activity.
    Nisin
  • HY-P0163
    Gramicidin 1405-97-6 ≥98.0%
    Gramicidin is an antimicrobial peptide assembling as channels in membranes and increasing their permeability towards cations.
    Gramicidin
  • HY-106783
    Polymyxin B nonapeptide 86408-36-8 99.83%
    Polymyxin B nonapeptide is a cyclic peptide obtained from Polymyxin B by proteolytic removal of its terminal amino acyl residue. Polymyxin B nonapeptide is less toxic, lacks bactericidal activity, and retains its ability to render gram-negative bacteria susceptible to several antibiotics by permeabilizing their outer membranes.
    Polymyxin B nonapeptide
  • HY-P1222A
    LL-37, human TFA 99.78%
    LL-37, human TFA is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human TFA could help protect the cornea from infection and modulates wound healing.
    LL-37, human TFA
  • HY-P1975
    Aureobasidin A 127785-64-2 99.36%
    Aureobasidin A (Basifungin) is a cyclic peptide antibiotic with oral activity. Aureobasidin A is an inhibitor of inositol phosphorylated ceramide synthetase AUR1. Aureobasidin A has antifungal and antiparasitic activity.
    Aureobasidin A
  • HY-N6708
    Alamethicin 27061-78-5 99.66%
    Alamethicin is a linear 20-amino acid antibiotic, which can induce voltage-gated conductance in model and cell membranes. Alamethicin exhibits antimicrobial activity against Gram-positive bacteria, but not Gram-negative bacteria. Alamethicin can form an amphipathic α-helical structure in biological membranes.
    Alamethicin
  • HY-P1222B
    LL-37, human acetate 99.71%
    LL-37, human acetate is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human acetate could help protect the cornea from infection and modulates wound healing.
    LL-37, human acetate
  • HY-P2322
    Iturin A 52229-90-0 98.53%
    Iturin A is a cyclic lipid peptide with strong antifungal activity. Iturin A induces ROS explosion and induces apoptosis and autophagy in tumor cells. Iturin A has antitumor activity.
    Iturin A
  • HY-P5712
    Gramicidin S 113-73-5 99.89%
    Gramicidin S (Gramicidin soviet) is a cationic cyclic peptide antibiotic that selectively targets bacterial cell membranes and has anticancer activity. Gramicidin S also exerts antibacterial activity by destroying membrane integrity and interfering with membrane protein function. Gramicidin S inserts into the phospholipid bilayer through hydrophobic amino acid residues, specifically binds to negatively charged membrane lipids and disrupts membrane structure, thereby inhibiting cell division and cell wall synthesis, and ultimately causing bacterial death. Gramicidin S also inhibits ion channels, with IC50s of 41 μM, 24 μM, and 3 μM for Na+/K+-ATPase, tobacco leaf plasma membrane Mg2+/K+-ATPase, and rat heart plasma membrane Ca2+-ATPase, respectively.
    Gramicidin S
  • HY-106268A
    Larazotide acetate 881851-50-9 99.68%
    Larazotide acetate is a peptide which is an orally active zonulin antagonist. Larazotide acetate shows antiviral activity to varicella-zoster virus (VZV) with EC50s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide acetate can be used for the research of celiac disease and infection.
    Larazotide acetate
  • HY-P1674A
    Murepavadin TFA 99.53%
    Murepavadin (POL7080) (TFA), a 14-amino-acid cyclic peptide, is a highly potent, specific antibiotic. Murepavadin exhibits a potent antimicrobial activity for P. aeruginosa with MIC50 and MIC90 values both of 0.12 mg/L. Murepavadin also can target the lipopolysaccharide transport portin D. Murepavadin can be used for the research of bacterial resistance.
    Murepavadin TFA
  • HY-P3466
    Nisin Z 137061-46-2
    Nisin Z is an antimicrobial and anti-inflammatory peptide. Nisin Z is effective against Gram-positive bacteria and fungi, such as C. albicans.
    Nisin Z