2. Metabolic Enzyme/Protease
  3. E1/E2/E3 Enzyme
  4. p27 Analogue CP2

p27 Analogue CP2 is a macrocyclic peptide inhibitor targeting the SCFSkp2/Cks1 E3 ubiquitin ligase (Kd=32 nM). p27 Analogue CP2 blocks SCFSkp2/Cks1-mediated ubiquitylation and degradation of p27, restoring p27 levels and inhibiting cell proliferation. p27 Analogue CP2 is promising for research of cancers dependent on Skp2 overexpression such as breast cancer.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

p27 Analogue CP2 Chemical Structure

p27 Analogue CP2 Chemical Structure

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p27 Analogue CP2 Related Antibodies

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Description

p27 Analogue CP2 is a macrocyclic peptide inhibitor targeting the SCFSkp2/Cks1 E3 ubiquitin ligase (Kd=32 nM). p27 Analogue CP2 blocks SCFSkp2/Cks1-mediated ubiquitylation and degradation of p27, restoring p27 levels and inhibiting cell proliferation. p27 Analogue CP2 is promising for research of cancers dependent on Skp2 overexpression such as breast cancer[1].

Molecular Weight

1341.33

Formula

C52H85N20O20P
Sequence

Ala-Gly-Ser-{X2}-Glu-Gln-Thr{phos}-Pro-{X3}-Lys
Sequence Shortening

AGS-{X2}-EQT-{phos}-P-{X3}-K
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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p27 Analogue CP2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p27 Analogue CP2E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseSCFSkp2/Cks1 E3 ubiquitin ligasecell proliferationbreast cancerInhibitorinhibitorinhibit

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