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  4. N-Methylpyrrolidone-d9

N-Methylpyrrolidone-d9  (Synonyms: NMP-d9; 1-Methyl-2-pyrrolidinone-d9)

Cat. No.: HY-Y1275S
Handling Instructions Technical Support

N-Methylpyrrolidone-d9 (NMP-d9) is deuterium labeled N-Methylpyrrolidone. N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a LD50 value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals.

For research use only. We do not sell to patients.

N-Methylpyrrolidone-d<sub>9</sub> Chemical Structure

N-Methylpyrrolidone-d9 Chemical Structure

CAS No. : 185964-60-7

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Other Forms of N-Methylpyrrolidone-d9:

N-Methylpyrrolidone-d9 Related Antibodies

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Description

N-Methylpyrrolidone-d9 (NMP-d9) is deuterium labeled N-Methylpyrrolidone. N-Methylpyrrolidone (1-Methyl-2-pyrrolidinone), a five-membered cyclic amide, is an orally active organic polar solvent with teratogenicity and toxicity. N-Methylpyrrolidone is low in acute toxicity with a LD50 value of 3914 mg/kg in rats and of 4050 mg/kg in mice. N-Methylpyrrolidone is extensively used in the manufacture of adhesives, paints, fuels, and pharmaceuticals[1][2][3][4].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

N-Methylpyrrolidone-d9 Related Antibodies
Molecular Weight

108.19

Formula

C5D9NO
CAS No.
Unlabeled CAS
SMILES

O=C1N(C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])C1([2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (924.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 9.2430 mL 46.2150 mL 92.4300 mL
5 mM 1.8486 mL 9.2430 mL 18.4860 mL
View the Complete Stock Solution Preparation Table

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 9.2430 mL 46.2150 mL 92.4300 mL 231.0750 mL
5 mM 1.8486 mL 9.2430 mL 18.4860 mL 46.2150 mL
10 mM 0.9243 mL 4.6215 mL 9.2430 mL 23.1075 mL
15 mM 0.6162 mL 3.0810 mL 6.1620 mL 15.4050 mL
20 mM 0.4621 mL 2.3107 mL 4.6215 mL 11.5537 mL
25 mM 0.3697 mL 1.8486 mL 3.6972 mL 9.2430 mL
30 mM 0.3081 mL 1.5405 mL 3.0810 mL 7.7025 mL
40 mM 0.2311 mL 1.1554 mL 2.3107 mL 5.7769 mL
50 mM 0.1849 mL 0.9243 mL 1.8486 mL 4.6215 mL
60 mM 0.1540 mL 0.7702 mL 1.5405 mL 3.8512 mL
80 mM 0.1155 mL 0.5777 mL 1.1554 mL 2.8884 mL
100 mM 0.0924 mL 0.4621 mL 0.9243 mL 2.3107 mL
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N-Methylpyrrolidone-d9 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Methylpyrrolidone-d9185964-60-7NMP-d9 1-Methyl-2-pyrrolidinone-d9Biochemical Assay ReagentsIsotope-Labeled CompoundsInhibitorinhibitorinhibit

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