2. PROTAC Cell Cycle/DNA Damage
  3. PROTACs DNA/RNA Synthesis
  4. aTAG 4531

aTAG 4531 (CFT-4531) is a potent, selective, and onmechanism tool degrader of MTH1 with DC50 value of 0.28 nM and Ki value of 1.8 nM. The degradation activity is due to the intricate formation of the ternary complex between the MTH1 aTAG, CRBN E3 ligase, and aTAG tool degrader. Red: MTH1 aTAG inhibitor (HY-134725), Blue: CRBN ligand (HY-126457), Black: linker (HY-108374).

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aTAG 4531

aTAG 4531 Chemical Structure

CAS No. : 2412985-00-1

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Based on 1 publication(s) in Google Scholar

aTAG 4531 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

aTAG 4531 (CFT-4531) is a potent, selective, and onmechanism tool degrader of MTH1 with DC50 value of 0.28 nM and Ki value of 1.8 nM. The degradation activity is due to the intricate formation of the ternary complex between the MTH1 aTAG, CRBN E3 ligase, and aTAG tool degrader. Red: MTH1 aTAG inhibitor (HY-134725), Blue: CRBN ligand (HY-126457), Black: linker (HY-108374)[1].

Molecular Weight

867.85

Formula

C46H39F2N9O7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=C(F)C=C(C2=CC3=C(NC4=CC=CC=C4)C(C(NC5CC5)=O)=CN=C3C=C2F)C=C1)NCCCCN6N=NC(COC7=CC=CC(C(N8C9C(NC(CC9)=O)=O)=O)=C7C8=O)=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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aTAG 4531 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

aTAG 45312412985-00-1CFT-4531aTAG4531aTAG-4531CFT4531CFT 4531PROTACsDNA/RNA Synthesisonmechanism toolCAR-T cellsInhibitorinhibitorinhibit

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aTAG 4531
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HY-163168
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