2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Cytochrome P450 Keap1-Nrf2 Heme Oxygenase (HO) Reactive Oxygen Species
  4. CYP2E1-IN-1

CYP2E1-IN-1 (Compound 10) is an orally active cytochrome P450 2E1 (CYP2E1) inhibitor with a Kd of 7.02 μM, an IC50 of 1.64 μM, and a Ki of 0.897 μM. CYP2E1-IN-1 activates the Nrf2/HO-1 signaling pathway and inhibits ROS production, thereby alleviating pancreatic injury. CYP2E1-IN-1 has significant anti-inflammatory and antioxidant activities and can effectively reduce inflammation and oxidative stress in severe acute pancreatitis (SAP). CYP2E1-IN-1 can be used in the study of SAP and other inflammatory-related diseases.

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CYP2E1-IN-1 Chemical Structure

CYP2E1-IN-1 Chemical Structure

CAS No. : 38205-55-9

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CYP2E1-IN-1 Related Antibodies

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

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HO-1 HO-2

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Description

CYP2E1-IN-1 (Compound 10) is an orally active cytochrome P450 2E1 (CYP2E1) inhibitor with a Kd of 7.02 μM, an IC50 of 1.64 μM, and a Ki of 0.897 μM. CYP2E1-IN-1 activates the Nrf2/HO-1 signaling pathway and inhibits ROS production, thereby alleviating pancreatic injury. CYP2E1-IN-1 has significant anti-inflammatory and antioxidant activities and can effectively reduce inflammation and oxidative stress in severe acute pancreatitis (SAP). CYP2E1-IN-1 can be used in the study of SAP and other inflammatory-related diseases[1].

Molecular Weight

141.19

Formula

C6H7NOS
CAS No.
Appearance

<28°C Solid,>29°C Liquid

SMILES

CC(C1=C(N=CS1)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Purity & Documentation
References
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CYP2E1-IN-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CYP2E1-IN-138205-55-9Cytochrome P450Keap1-Nrf2Heme Oxygenase (HO)Reactive Oxygen SpeciesCYPsHeme OxygenaseCYP450SAPCYP2E1AR42J cellsC57BL/6J miceInhibitorinhibitorinhibit

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