2. Others PI3K/Akt/mTOR Stem Cell/Wnt
  3. Biochemical Assay Reagents GSK-3
  4. AZ12943203

AZ12943203 (Compound 13e) is a PET radioligand with a Kd of 2.94  nM. AZ12943203 has a significant inhibitory potency toward GSK-3β (IC50 : 4.44 nM), and can specifically bind to GSK-3-rich regions of the rodent brain. AZ12943203 can be used for neurodegenerative diseases imaging, particularly Alzheimer’s disease.

For research use only. We do not sell to patients.

AZ12943203 Chemical Structure

AZ12943203 Chemical Structure

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Description

AZ12943203 (Compound 13e) is a PET radioligand with a Kd of 2.94  nM. AZ12943203 has a significant inhibitory potency toward GSK-3β (IC50 : 4.44 nM), and can specifically bind to GSK-3-rich regions of the rodent brain. AZ12943203 can be used for neurodegenerative diseases imaging, particularly Alzheimer’s disease[1].

Molecular Weight

493.58

Formula

C26H32FN7O2
SMILES

CC(N1CCN(CC2=CC=C(NC3=NC=C(F)C(C4=CN=C(C)N4C5CCOCC5)=N3)C=C2)CC1)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AZ12943203 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZ12943203AZ 12943203AZ-12943203Biochemical Assay ReagentsGSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3PETRadioligandAlzheimer’s diseaseInhibitorinhibitorinhibit

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