2. Cell Cycle/DNA Damage Epigenetics
  3. Aurora Kinase
  4. AURKA-IN-3

AURKA-IN-3 (Compound AL8) is an irreversible covalent Aurora kinase A (AURKA) inhibitor with an IC50 value of 23.0 nM. AURKA-IN-3 inhibits the activation of cAMP signaling pathway and phospholipase C (PLC) signaling pathway mediated by AURKA, and reduces the autophosphorylation level of AURKA. AURKA-IN-3 is promising for research of malignant tumors associated with high AURKA expression (e.g., leukemia, lymphoma).

For research use only. We do not sell to patients.

AURKA-IN-3

AURKA-IN-3 Chemical Structure

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AURKA-IN-3 Related Antibodies

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Aurora Kinase Aurora A Aurora B Aurora C

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Description

AURKA-IN-3 (Compound AL8) is an irreversible covalent Aurora kinase A (AURKA) inhibitor with an IC50 value of 23.0 nM. AURKA-IN-3 inhibits the activation of cAMP signaling pathway and phospholipase C (PLC) signaling pathway mediated by AURKA, and reduces the autophosphorylation level of AURKA. AURKA-IN-3 is promising for research of malignant tumors associated with high AURKA expression (e.g., leukemia, lymphoma)[1].

IC50 & Target

Aurora A

23.0 nM (IC50)

Molecular Weight

719.12

Formula

C38H28ClFN6O6
SMILES

O=C(NC1=CC=C(NC2=C(OC)C(C2=O)=O)C=C1)C3=CC=C(NC4=NC=C5C(C6=CC=C(Cl)C=C6C(C7=C(OC)C=CC=C7F)=NC5)=N4)C=C3OC
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AURKA-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AURKA-IN-3Aurora KinaseAURKAPLCmalignant tumorsInhibitorinhibitorinhibit

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