(E/Z)-Mirin

Cat. No.: HY-117693: FAQs
Data Sheet
SDS
Handling Instructions Technical Support

(E/Z)-Mirin is a mixture of (E)-Mirin and Mirin ((Z)-Mirin) (HY-19959) configurations. Among them, Mirin is an inhibitor of MRN (Mre11-Rad50-Nbs1). Mirin prevents MRN-dependent ATM activation without affecting ATM protein kinase activity.

For research use only. We do not sell to patients.

(E/Z)-Mirin Chemical Structure

CAS No. : 299953-00-7

Size	Price	Stock
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution		Ask For Quote & Lead Time
Solution
10 mM * 1 mL in DMSO		Ask For Quote & Lead Time
Solid
5 mg		Ask For Quote & Lead Time
10 mg		Ask For Quote & Lead Time
50 mg		Ask For Quote & Lead Time
100 mg		Ask For Quote & Lead Time

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of (E/Z)-Mirin:

Mirin In-stock

4 Publications Citing Use of MCE (E/Z)-Mirin

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All ATM/ATR Isoform Specific Products:

View All Isoforms

ATM ATR

Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

220.25

Formula

C₁₀H₈N₂O₂S

CAS No.

299953-00-7

Appearance

Solid

Color

Brown to orange

SMILES

O=C1N=C(N)S/C1=C/C2=CC=C(O)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 83.33 mg/mL (378.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.5403 mL	22.7015 mL	45.4030 mL
5 mM	0.9081 mL	4.5403 mL	9.0806 mL
10 mM	0.4540 mL	2.2701 mL	4.5403 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Data Sheet (272 KB) SDS (393 KB) Handling Instructions (2659 KB)

References

[1]. Dupré A, et al. A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol. 2008;4(2):119-125. [Content Brief]

[2]. Ying S, et al. Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1. Cancer Res. 2012;72(11):2814-2821. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.5403 mL	22.7015 mL	45.4030 mL	113.5074 mL
	5 mM	0.9081 mL	4.5403 mL	9.0806 mL	22.7015 mL
	10 mM	0.4540 mL	2.2701 mL	4.5403 mL	11.3507 mL
	15 mM	0.3027 mL	1.5134 mL	3.0269 mL	7.5672 mL
	20 mM	0.2270 mL	1.1351 mL	2.2701 mL	5.6754 mL
	25 mM	0.1816 mL	0.9081 mL	1.8161 mL	4.5403 mL
	30 mM	0.1513 mL	0.7567 mL	1.5134 mL	3.7836 mL
	40 mM	0.1135 mL	0.5675 mL	1.1351 mL	2.8377 mL
	50 mM	0.0908 mL	0.4540 mL	0.9081 mL	2.2701 mL
	60 mM	0.0757 mL	0.3784 mL	0.7567 mL	1.8918 mL
	80 mM	0.0568 mL	0.2838 mL	0.5675 mL	1.4188 mL
	100 mM	0.0454 mL	0.2270 mL	0.4540 mL	1.1351 mL

(E/Z)-Mirin Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(E/Z)-Mirin299953-00-7ATM/ATRAtaxia telangiectasia mutatedATM and RAD3 relatedH2AXphosphorylationChk2G2arrestDSBrepairInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *