Anti-Chikungunya virus E2 Antibody (CHK-265)

Cat. No.: HY-P990825 Purity: 95%: Data Sheet
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Anti-Chikungunya virus E2 Antibody (CHK-265) is mouse-derived IgG2c κ type antibody inhibitor, targeting to Chikungunya virus E2. Anti-Chikungunya virus E2 Antibody (CHK-265) reacts with a conserved epitope on the B domain of the E2 glycoprotein of chikungunya virus. Anti-Chikungunya virus E2 Antibody (CHK-265) can block viral entry and egress. Anti-Chikungunya virus E2 Antibody (CHK-265) can be used for the research of infection, such as Chikungunya virus (CHIKV), Mayaro (MAYV) and O’nyong’nyong virus (ONNV).

For research use only. We do not sell to patients.

Anti-Chikungunya virus E2 Antibody (CHK-265) Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Anti-Chikungunya virus E2 Antibody (CHK-265) Featured Recommendations:

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Description

Isotype

Mouse IgG2c

Recommend Isotype Controls

Mouse IgG2c kappa, Isotype Control

Species Reactivity

Virus

IC₅₀ & Target

B domain of the E2 glycoprotein of chikungunya virus

In Vitro

Anti-Chikungunya virus E2 Antibody (CHK-265) (0.001-10 μg/mL, 19 h) neutralizes alphaviruses that are closely (ONNV) or distantly (MAYV, RRV, and SFV) related to CHIKV^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-Chikungunya virus E2 Antibody (CHK-265) (100 μg, i.p., 1 day prior to infection) protect against alphavirus disease in CHIKV/MAYV/ONNV infected mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	CHIKV/MAYV/ONNV infected mice models^[1]
Dosage:	100 μg
Administration:	Intraperitoneally injection, 1 day prior to infection
Result:	Reduced ankle joint swelling. Reduced spread to the contralateral ankle joint. Decreased viral burden.

Accession

ADG95913

Application

ELISA, FACS, Functional assay, Research in vivo

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Chikungunya virus E2 Antibody (CHK-265)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: 95%

Select Batch:

Data Sheet (259 KB) SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Fox JM, et al. Broadly Neutralizing Alphavirus Antibodies Bind an Epitope on E2 and Inhibit Entry and Egress. Cell. 2015 Nov 19;163(5):1095-1107. [Content Brief]

Anti-Chikungunya virus E2 Antibody (CHK-265) Related Classifications

Infection

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Chikungunya virus E2 Antibody (CHK-265)FlavivirusCHIKVChikungunya virusAlphavirusesMayaroO’nyong’nyong virusInhibitorinhibitorinhibit

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