2. Inhibitory Antibodies
  3. In Vivo Antibodies

In Vivo Antibodies

MCE In Vivo Antibodies are used for in vivo and in vitro studies in animal models such as mice and rats, and maintain stable neutralizing/blocking antibody efficacy after repeated in vivo injections. MCE In Vivo Antibodies target a wide range of immune checkpoints, cytokines, lymphocyte markers, and tumor-associated antigens, and are available as Isotype Control Antibodies.

In Vivo Antibodies (287):

Cat. No. Product Name Purity  
  • HY-P99144
    Anti-Mouse PD-1 Antibody (RMP1-14) 99.63%  
    Anti-Mouse PD-1 Antibody (RMP1-14) is an anti-mouse PD-1 IgG2a antibody. Anti-Mouse PD-1 Antibody (RMP1-14) can be used for the study of colon carcinoma.
  • HY-P99145
    Anti-Mouse PD-L1/B7-H1 Antibody (10F.9G2) 99.60%  
    Anti-Mouse PD-L1/B7-H1 Antibody (10F.9G2) is an anti-mouse PD-L1/B7-H1 IgG2b antibody inhibitor derived from host rat. Anti-Mouse PD-L1/B7-H1 Antibody (10F.9G2) blocks PD-1 signaling. Anti-Mouse PD-L1/B7-H1 Antibody (10F.9G2) can be used for the research of cancer, such as colon cancer.
  • HY-P99126
    Anti-Mouse/Human CD44 Antibody (IM7) 99.00%  
    Anti-Mouse/Human CD44 Antibody (IM7) is an anti-huamn and mouse CD44 IgG2b monoclonal antibody. Anti-Mouse/Human CD44 Antibody (IM7) relieves inflammation and induces cell apoptosis by blocking the interaction between CD44 and hyaluronic acid. Anti-Mouse/Human CD44 Antibody (IM7) can be used for research on inflammation conditions and cancer such as arthritis and osteosarcoma.
  • HY-P99137
    Anti-Mouse IFNAR1 Antibody (MAR1-5A3) 99.00%  
    Anti-Mouse IFNAR1 Antibody (MAR1-5A3) is a neutralizing antibody of IFNAR1. Anti-Mouse IFNAR1 Antibody (MAR1-5A3) reacts with IFNAR1 and inhibits IFNAR1 signaling in vitro and in vivo. Mouse IgG1 kappa, Isotype Control (HY-P99977) is the isotype control of Anti-Mouse IFNAR1 Antibody (MAR1-5A3).
  • HY-P99132
    Anti-Mouse CTLA-4 Antibody (9D9) ≥98.0%  
    Anti-Mouse CTLA-4 Antibody (9D9) is an anti-mouse CTLA-4 IgG2b monoclonal antibody. Anti-Mouse CTLA-4 Antibody (9D9) can bind to CTLA-4 and block its binding to B7. Anti-Mouse CTLA-4 Antibody (9D9) enhances T cell function by regulating the ratio of CD8+ T cells to regulatory T cells (Tregs). Anti-Mouse CTLA-4 Antibody (9D9) can be used for research on cancer such as colon cancer and melanoma.
  • HY-P991078
    Anti-Mouse PD-1 (LALA-PG) Antibody (RMP1-14)  
    Anti-Mouse PD-1 (LALA-PG) Antibody (RMP1-14) is a mouse-derived IgG2a, κ type antibody inhibitor, targeting to mouse PD-1.
  • HY-P99382A
    Vopratelimab (Mouse IgG2a)  
    Vopratelimab (Mouse IgG2a) is a monoclonal antibody that selectively targets Inducible CO-Stimulator of T cells (ICOS). The variable region of Vopratelimab (Mouse IgG2a) is consistent with that of Vopratelimab (HY-P99382), while the constant region is of Mouse IgG2a sequence. Vopratelimab (Mouse IgG2a) has antitumor immune response and enhances combinatorial efficacy with anti-PD-1 (HY-P9902A) therapy.
  • HY-P991110
    Anti-Mouse CD25 Antibody (7D4)  
    Anti-Mouse CD25 Antibody (7D4) is a mouse IgG2 monoclonal antibody that targets CD25. Recommend Isotype Controls: Mouse IgG2a kappa, Isotype Control (HY-P99978).
  • HY-P99136
    Anti-Mouse IFN gamma Antibody (H22)  
    Anti-Mouse IFN gamma Antibody (H22) is an anti-mouse IFN gamma IgG antibody inhibitor derived from host Armenian Hamster. Anti-Mouse IFN gamma Antibody (H22) abrogates specific binding of I25II-rIFN-γ to macrophages. Anti-Mouse IFN gamma Antibody (H22) inhibits macrophage-activating factor (MAF) (ID50 = 56 ng). Anti-Mouse IFN gamma Antibody (H22) inhibits IFN-gamma dependent antiviral activity (ID50 = 2 ng). Anti-Mouse IFN gamma Antibody (H22) neutralizes IFNγ in mice. Anti-Mouse IFN gamma Antibody (H22) can be used for the researches of inflammation and infection, such as arthritis.
  • HY-P99124
    Anti-Mouse CD3 Antibody (17A2) 98.56%  
    Anti-Mouse CD3 Antibody (17A2) is an anti-mouse CD3 IgG2b antibody inhibitor derived from the host Rat. Anti-Mouse CD3 Antibody (17A2) enhances T-cell proliferation and activation and stimulate IFN-γ or IL-17 production in splenic T cells. Anti-Mouse CD3 Antibody (17A2) significantly suppresses mortality in Graft-versus-host disease (GVHD) mice models.
  • HY-P99144A
    Anti-Mouse PD-1 Antibody (S-5001)  
    Anti-Mouse PD-1 Antibody (S-5001) is an anti-mouse PD-1 IgG1 antibody inhibitor.
  • HY-P990148
    Anti-Mouse VEGF-A Antibody (2G11-2A05)  
    Anti-Mouse VEGF-A Antibody (2G11-2A05) is a rat-derived anti-VEGF-A IgG2a, κ type antibody inhibitor, binding to mouse VEGF-A with high affinity. Anti-Mouse VEGF-A Antibody (2G11-2A05) shows good anti-tumor effect in gastric cancer xenograft models.
  • HY-P99123
    Anti-Mouse CD28 Antibody (37.51)  
    Anti-Mouse CD28 Antibody (37.51) is an agonistic agonistic CD28-specific antibody derived from the host Syrian Hamster. Anti-Mouse CD28 Antibody (37.51) partially prevents lethal graft-versus-hostdisease (GVHD) by selective depletion of alloreactive T cells in mice.
  • HY-P990117
    Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10)  
    Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) is a mouse-derived Osteopontin/SPP1 IgG1, κ type antibody inhibitor. Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) blocks Angiotensin II (HY-13948)-induced DNA synthesis and collagen gel contraction in cardiac fibroblasts. Anti-Mouse/Rat/Human Osteopontin/SPP1 Antibody (MPIIIB10) significantly inhibits tumor growth in CT26 or MC38 tumors mice models.
  • HY-P990211
    Anti-Mouse IL-6R Antibody (15A7) 98.47%  
    Anti-Mouse IL-6R Antibody (15A7) is a rat-derived anti-mouse IL-6R IgG2b κ type antibody inhibitor. Anti-Mouse IL-6R Antibody (15A7) blocks IL-6 binding to IL-6Rα and inhibits both IL-6 classic and trans-signaling. Anti-Mouse IL-6R Antibody (15A7) can be used for the researches of cancer and inflammation, such as triple-negative breast cancer.
  • HY-P990222
    Anti-Mouse/Rat IL-17A Antibody (17F3) 99.04%  
    Anti-Mouse/Rat IL-17A Antibody (17F3) is a mouse-derived IgG1, κ type antibody inhibitor, targeting to mouse/rat IL-17A.
  • HY-P99148
    Anti-Mouse/Rat/Rabbit TNF alpha Antibody (TN3-19.12)  
    Anti-Mouse TNF alpha Antibody (TN3-19.12) is an anti-mouse TNF alpha IgG antibody inhibitor derived from host Armenian Hamster. Anti-Mouse TNF alpha Antibody (TN3-19.12) neutralizes cytotoxic activity in supernatants obtained from LNC-8 cells. Anti-Mouse TNF alpha Antibody (TN3-19.12) reduces the symptoms and severity of EAE (experimental allergic encephalomyelitis) in LNC-8 cells xenograft mice models. Anti-Mouse TNF alpha Antibody (TN3-19.12) prevents diabetes in NOD mice. Anti-Mouse TNF alpha Antibody (TN3-19.12) shows apparent radiosensitizing effect in CD2F1 mice.
  • HY-P990106
    Anti-Mouse VEGFR-2 Antibody (DC101) 99.41%  
    Anti-Mouse VEGFR-2 Antibody (DC101) is a rat anti-mouse VEGFR2 monoclonal antibody. Anti-Mouse VEGFR-2 Antibody (DC101) inhibits tumor angiogenesis by blocking the binding of VEGF and VEGFR2. Anti-Mouse VEGFR-2 Antibody (DC101) promotes immune cell infiltration and induces tumor cell apoptosis. Anti-Mouse VEGFR-2 Antibody (DC101) can be used for research on various types of cancer such as melanoma, lung cancer and breast cancer .
  • HY-P990212
    Anti-Mouse IL-6 Antibody (MP5-20F3) 99.20%  
    Anti-Mouse IL-6 Antibody (MP5-20F3) is an anti-mouse IL-6 IgG1 monoclonal antibody. Anti-Mouse IL-6 Antibody (MP5-20F3) reshapes the tumor microenvironment by blocking IL-6. Anti-Mouse IL-6 Antibody (MP5-20F3) can inhibit the STAT3 pathway and enhance T cell infiltration. Anti-Mouse IL-6 Antibody (MP5-20F3) can be used for research on inflammation and infection conditions such as malignant pleural effusion (MPE).
  • HY-P990001
    Anti-Mouse IL-10 Antibody (JES5-2A5)  
    Anti-Mouse IL-10 Antibody (JES5-2A5) is an anti-mouse IL-10 IgG1 monoclonal antibody. Anti-Mouse IL-10 Antibody (JES5-2A5) restores the anti-tumor activity of IL-6 by blocking the IL-10/SOCS3 axis. Anti-Mouse IL-10 Antibody (JES5-2A5) can reverse microcirculation and cognitive deficits. Anti-Mouse IL-10 Antibody (JES5-2A5) can be used for research on cancer and metabolic disease such as osteosarcoma and type 1 diabetes mellitus (T1DM).