Anti-Mouse IFNAR1 Antibody (MAR1-5A3)

Cat. No.: HY-P99137 Purity: ≥99.0%: Data Sheet
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Anti-Mouse IFNAR1 Antibody (MAR1-5A3) is a neutralizing antibody of IFNAR1. Anti-Mouse IFNAR1 Antibody (MAR1-5A3) reacts with IFNAR1 and inhibits IFNAR1 signaling in vitro and in vivo. Mouse IgG1 kappa, Isotype Control (HY-P99977) is the isotype control of Anti-Mouse IFNAR1 Antibody (MAR1-5A3).

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1 mg		In-stock	Estimated Time of Arrival: December 31
5 mg		In-stock	Estimated Time of Arrival: December 31
10 mg		In-stock	Estimated Time of Arrival: December 31
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Description	Anti-Mouse IFNAR1 Antibody (MAR1-5A3) is a neutralizing antibody of IFNAR1. Anti-Mouse IFNAR1 Antibody (MAR1-5A3) reacts with IFNAR1 and inhibits IFNAR1 signaling in vitro and in vivo. Mouse IgG1 kappa, Isotype Control (HY-P99977) is the isotype control of Anti-Mouse IFNAR1 Antibody (MAR1-5A3)^[1]^[2].
Isotype	Mouse IgG1 kappa
Recommend Isotype Controls	Mouse IgG1 kappa, Isotype Control
Species	Mouse
In Vitro	Anti-Mouse IFNAR1 Antibody (MAR1-5A3) (20 μg/ml, 18 h) inhibits IFNAR1 signaling in Bone marrow-derived macrophages^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Anti-Mouse IFNAR1 Antibody (MAR1-5A3) Related Antibodies
In Vivo	Anti-Mouse IFNAR1 Antibody (MAR1-5A3) (250-500 μg/mouse for i.p.) inhibits IFNAR1 signaling in WT mice model^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application	ELISA, FACS, Functional assay, Research in vivo
Conjugated	Unconjugated
Reconsititution	The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight	150 kDa
Appearance	Liquid
Color	Colorless to light yellow
SMILES	[Anti-Mouse IFNAR1 Antibody (MAR1-5A3)]
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity	Immobilized IFNAR1 Protein, Mouse (HEK293, His, HY-P73127) can bind Anti-Mouse IFNAR1 Antibody (MAR1-5A3). The EC₅₀ for this effect is 12.87 ng/mL.
Purity & Documentation	Purity: ≥99.0% Select Batch: Data Sheet (258 KB) SDS (251 KB) COA (232 KB) SDS-PAGE (60 KB) SEC-HPLC (68 KB) Inhibitory Antibodies User Guide (602 KB)
References	[1]. Macal M, et al. Self-Renewal and Toll-like Receptor Signaling Sustain Exhausted Plasmacytoid Dendritic Cells during Chronic Viral Infection. Immunity. 2018 Apr 17;48(4):730-744.e5. [Content Brief] [2]. Schliehe C, et al. The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection. Nat Immunol. 2015 Jan;16(1):67-74. [Content Brief]

Anti-Mouse IFNAR1 Antibody (MAR1-5A3) Related Classifications

Inflammation/Immunology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IFNAR1 Antibody (MAR1-5A3)IFNARInterferon-α/β receptorInterferon-alpha/beta receptorInhibitorinhibitorinhibit

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Immobilized IFNAR1 Protein, Mouse (HEK293, His, HY-P73127) can bind Anti-Mouse IFNAR1 Antibody (MAR1-5A3). The EC₅₀ for this effect is 12.87 ng/mL.

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