2. Immunology/Inflammation Apoptosis
  3. Transmembrane Glycoprotein Apoptosis
  4. Anti-Mouse/Human CD44 Antibody (IM7)

Anti-Mouse/Human CD44 Antibody (IM7) 

Cat. No.: HY-P99126 Purity: 99.00%
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Anti-Mouse/Human CD44 Antibody (IM7) is an anti-huamn and mouse CD44 IgG2b monoclonal antibody. Anti-Mouse/Human CD44 Antibody (IM7) relieves inflammation and induces cell apoptosis by blocking the interaction between CD44 and hyaluronic acid. Anti-Mouse/Human CD44 Antibody (IM7) can be used for research on inflammation conditions and cancer such as arthritis and osteosarcoma.

For research use only. We do not sell to patients.

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Description

Anti-Mouse/Human CD44 Antibody (IM7) is an anti-huamn and mouse CD44 IgG2b monoclonal antibody. Anti-Mouse/Human CD44 Antibody (IM7) relieves inflammation and induces cell apoptosis by blocking the interaction between CD44 and hyaluronic acid. Anti-Mouse/Human CD44 Antibody (IM7) can be used for research on inflammation conditions and cancer such as arthritis and osteosarcoma[1][2].

IC50 & Target

CD44
In Vitro

Anti-Mouse/Human CD44 Antibody (IM7) (0.05-50 μg/mL, 24-72 h) significantly reduces cell activity of SW1353 cells in a time-dependent manner[1].
Anti-Mouse/Human CD44 Antibody (IM7) (50 μg/mL, 72 h) significantly induces cell apoptosis of SW1353 cells[1].
Anti-Mouse/Human CD44 Antibody (IM7) (12-20 h) inhibits the migration and adhesion of inflammatory cells by inducing CD44 shedding and blocking hyaluronic acid binding in white blood cells and synovial cells from arthritis mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse/Human CD44 Antibody (IM7) Related Antibodies

Cell Viability Assay[1]

Cell Line: SW1353 cells
Concentration: 0.05, 5 and 50 μg/mL
Incubation Time: 24, 48 and 72 h
Result: Significantly reduced the activity of SW1353 cells after 72 hours.
In Vivo

Anti-Mouse/Human CD44 Antibody (IM7) (50 and 100 μg, i.p., once daily, for 10 days) significantly alleviates symptoms of arthritis without significant side effects in BALB/c mice and DBA/1 mice with arthritis[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice with proteoglycan-arthritis and DBA/1 mice with collagen-arthritis[2]
Dosage: Initial dose of 100 µg, maintenance dose of 50 µg
Administration: Intraperitoneal injection (i.p.), once daily, for 10 days
Result: Significantly reduced joint swelling within 24-36 hours.
Restored normal joint function in mice after 8 days of treatment.
Significantly reduced leukocyte infiltration in synovium.
Prevented white blood cells from migrating to synovial tissue, but does not affect their homing to lymph nodes.
Gene ID

12505  [NCBI]

Accession

NP_001034240.1
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse/Human CD44 Antibody (IM7)]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Immobilized CD44 Protein, Mouse (HEK293, His, HY-P74291) can bind Anti-Mouse CD44 Antibody (IM7). The EC50 for this effect is 0.165 μg/mL.
Purity & Documentation

Purity: 99.00%

SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Anti-Mouse/Human CD44 Antibody (IM7) Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse/Human CD44 Antibody (IM7)Transmembrane GlycoproteinApoptosisCD44inflammationcancerarthritisosteosarcomaSW1353Inhibitorinhibitorinhibit

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