2. Immunology/Inflammation
  3. Interleukin Related
  4. Anti-Mouse IL-6R Antibody (15A7)

Anti-Mouse IL-6R Antibody (15A7) 

Cat. No.: HY-P990211 Purity: 98.47%
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Anti-Mouse IL-6R Antibody (15A7) is a rat-derived anti-mouse IL-6R IgG2b κ type antibody inhibitor. Anti-Mouse IL-6R Antibody (15A7) blocks IL-6 binding to IL-6Rα and inhibits both IL-6 classic and trans-signaling. Anti-Mouse IL-6R Antibody (15A7) can be used for the researches of cancer and inflammation, such as triple-negative breast cancer.

For research use only. We do not sell to patients.

Anti-Mouse IL-6R Antibody (15A7)

Anti-Mouse IL-6R Antibody (15A7) Chemical Structure

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Description

Anti-Mouse IL-6R Antibody (15A7) is a rat-derived anti-mouse IL-6R IgG2b κ type antibody inhibitor. Anti-Mouse IL-6R Antibody (15A7) blocks IL-6 binding to IL-6Rα and inhibits both IL-6 classic and trans-signaling. Anti-Mouse IL-6R Antibody (15A7) can be used for the researches of cancer and inflammation, such as triple-negative breast cancer[1][2][3][4].

Isotype

Rat IgG2b kappa
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

IL-6R
In Vitro

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse IL-6R Antibody (15A7) Related Antibodies
In Vivo

Anti-Mouse IL-6R Antibody (15A7) (100 μg, i.v., a single dose) inhibits leukocyte accumulation in air pouch mice model of local inflammation[1].
Anti-Mouse IL-6R Antibody (15A7) (2.5 mg/kg, i.v., semiweekly for 3 weeks) shows anti-tumor effect in triple-negative breast cancer mice models[2].
Anti-Mouse IL-6R Antibody (15A7) (10 mg/kg, i.p., after 6 h of IL-1α injection) efficiently crosses the maternal–foetal interface, restores foetal growth, and dampens foetal inflammation in pregnant IL-1α-induced inflammation mice models[3].
Anti-Mouse IL-6R Antibody (15A7) (0.5-3 mg, s.c., 24 h before T1033C2 injection) inhibits tumor growth and increases survival rate in T1033C2 plasmacytoma mice models[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Triple-negative breast cancer mice models[2]
Dosage: 2.5 mg/kg
Administration: Intravenously injection, semiweekly for 3 weeks
Result: Increased survival rate.
Inhibited postsurgical lung nodules metastasis.
Reduced CD163(+) M2 macrophage and Foxp3(+) Treg infiltration.
Animal Model: IL-1α-induced systemic inflammation mice models (pregnant)[3]
Dosage: 10 mg/kg
Administration: Intraperitoneally injection, after 6 h of IL-1α injection
Result: Could be detected in the intraamniotic space.
Prevented the IL-1α-induced expression of Ccl3, Nlrp3, Il12a, and Lrg1 in the placenta.
Decreased TNF and IL-6 levels.
Prevented the IL-1α-driven dysregulation of Il1a, Il1b, Tnf, and Lrg1 in the foetal brain, P2rx7 in the foetal lung, and S100a9 in the foetal intestine.
Protected against IL-1α-induced foetal growth restriction.
Improved adverse neonatal outcomes induced by intra-amniotic IL-1α.
Restored IL-1α-induced neonatal gut immune-microbiome alterations.
Animal Model: T1033C2 plasmacytoma mice models[4]
Dosage: 0.5-3 mg
Administration: Subcutaneously injection, 24 h before T1033C2 injection
Result: Showed protection rate of 60%.
Gene ID

16193  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse IL-6R Antibody (15A7)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 98.47%

COA (232 KB) SDS-PAGE (65 KB) SEC-HPLC (127 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Anti-Mouse IL-6R Antibody (15A7) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-6R Antibody (15A7)Interleukin RelatedILIL-6RCancerInflammationTriple-negative breast cancerPlasmacytomaInhibitorinhibitorinhibit

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