2. Immunology/Inflammation
  3. Osteopontin
  4. Anti-Mouse osteopontin/SPP1 Antibody (103D6)

Anti-Mouse osteopontin/SPP1 Antibody (103D6) 

Cat. No.: HY-P990116 Purity: 95.00%
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Anti-Mouse osteopontin/SPP1 Antibody (103D6) is a mouse-derived anti-mouse osteopontin/SPP1 IgG2c κ type antibody inhibitor. Anti-Mouse osteopontin/SPP1 Antibody (103D6) increases cytotoxic T lymphocyte lytic activity and suppresses colon tumor growth. Anti-Mouse osteopontin/SPP1 Antibody (103D6) ameliorates liver injury in common bile duct ligation (CBDL)-induced primary sclerosing cholangitis mice models.

For research use only. We do not sell to patients.

Anti-Mouse osteopontin/SPP1 Antibody (103D6)

Anti-Mouse osteopontin/SPP1 Antibody (103D6) Chemical Structure

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Description

Anti-Mouse osteopontin/SPP1 Antibody (103D6) is a mouse-derived anti-mouse osteopontin/SPP1 IgG2c κ type antibody inhibitor. Anti-Mouse osteopontin/SPP1 Antibody (103D6) increases cytotoxic T lymphocyte lytic activity and suppresses colon tumor growth. Anti-Mouse osteopontin/SPP1 Antibody (103D6) ameliorates liver injury in common bile duct ligation (CBDL)-induced primary sclerosing cholangitis mice models[1][2].

Isotype

Mouse IgG2c kappa
Recommend Isotype Controls
Species Reactivity

Mouse
IC50 & Target

osteopontin/SPP1
In Vitro

Anti-Mouse osteopontin/SPP1 Antibody (103D6) (24 h) significantly increases the lytic activity of a tumor-specific CTL in lysing the target CT26 tumor cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse osteopontin/SPP1 Antibody (103D6) Related Antibodies
In Vivo

Anti-Mouse osteopontin/SPP1 Antibody (103D6) (200 μg/mouse, s,c., every 3 days for 14 days) suppresses CT26 tumor growth in colon tumor mice models[1].
Anti-Mouse osteopontin/SPP1 Antibody (103D6) (200 μg/mouse, before CBDL operation and at day 0, 2, day 5 and day 7 following CBDL) ameliorates liver injury in common bile duct ligation (CBDL)-induced primary sclerosing cholangitis mice models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Colon tumor mice models injected with CT 26 cells (BALB/c, 2-3 months)[1]
Dosage: 200 μg/mouse
Administration: Subcutaneously injection, every 3 days for 14 days
Result: Suppressed CT26 tumor growth.
Animal Model: Common bile duct ligation (CBDL)-induced primary sclerosing cholangitis mice models (C57BL6/J, male, 8 weeks)[2]
Dosage: 200 μg/mouse
Administration: Before CBDL operation and at day 2, day 5 and day 7 following CBDL
Result: Showed lower serum alanine transaminase.
Had less ductular reaction, necrosis and fibrosis.
Decreased expression levels of inflammatoryand fibrotic markers.
Gene ID

20750  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse osteopontin/SPP1 Antibody (103D6)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 95.00%

SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Anti-Mouse osteopontin/SPP1 Antibody (103D6) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse osteopontin/SPP1 Antibody (103D6)OsteopontinSecreted Phosphoprotein 1SPP1Cytotoxic T lymphocyteColon tumorCBDLInhibitorinhibitorinhibit

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Anti-Mouse osteopontin/SPP1 Antibody (103D6)
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