2. Inhibitory Antibodies
  3. In Vivo Antibodies
  4. Anti-Mouse Ly6G Antibody (1A8)

Anti-Mouse Ly6G Antibody (1A8) 

Cat. No.: HY-P990118 Purity: 95.00%
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Anti-Mouse Ly6G Antibody (1A8) is a rat-derived anti-mouse Ly6G IgG2a, κ type antibody inhibitor. Anti-Mouse Ly6G Antibody (1A8) can deplete neutrophil in various mice. Anti-Mouse Ly6G Antibody (1A8) can be used for the researches of inflammation, such as arthritis and peritonitis[2].

For research use only. We do not sell to patients.

Anti-Mouse Ly6G Antibody (1A8) Chemical Structure

Anti-Mouse Ly6G Antibody (1A8) Chemical Structure

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Description

Anti-Mouse Ly6G Antibody (1A8) is a rat-derived anti-mouse Ly6G IgG2a, κ type antibody inhibitor. Anti-Mouse Ly6G Antibody (1A8) can deplete neutrophil in various mice. Anti-Mouse Ly6G Antibody (1A8) can be used for the researches of inflammation, such as arthritis and peritonitis[1][2].

Isotype

Rat IgG2a kappa
Recommend Isotype Controls
IC50 & Target

Ly6G
In Vitro

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse Ly6G Antibody (1A8) Related Antibodies
In Vivo

Anti-Mouse Ly6G Antibody (1A8) (25-100 µg, i.p., 3 times a week) induces neutrophil depletion in various mice, including C57Bl6/J and IMR32 tumor bearing SCID mice[1].
Anti-Mouse Ly6G Antibody (1A8) (5 µg, i.p., 1 day before arthritis induction and again at day 2) abrogates arthritis in IgG immune complex-mediated K/BxN serum transfer arthritis mice models[2].
Anti-Mouse Ly6G Antibody (1A8) (5 µg, i.p., 5 days before and once again 3 days before peritonitis) inhibits integrin–mediated neutrophil migration in peritonitis mice model induced by IL-1β[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57Bl6/J, Balb/c, NXG, and SCID mice (>20 weeks)[1]
Dosage: 25 and 100 µg
Administration: Intraperitoneally injection, 3 times a week
Result: Efficiently deplete neutrophils.
Animal Model: SCID mice were injected with IMR32 cells in a 1:2 mix with Vitrogel Hydrogel Matrix[1]
Dosage: 100 µg
Administration: Intraperitoneally injection, 3 times a week
Result: Showed complete neutrophil depletion.
Animal Model: IgG immune complex-mediated K/BxN serum transfer arthritis mice models[2]
Dosage: 5 µg
Administration: Intraperitoneally injection, 1 day before arthritis induction and again at day 2
Result: Abrogated arthritis.
Animal Model: Peritonitis model induced by IL-1β[2]
Dosage: 5 µg
Administration: Intraperitoneally injection, 5 days before and once again 3 days before peritonitis
Result: Altered the ratio of WT-to-CD18-/- migrated neutrophils.
Gene ID

546644  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse Ly6G Antibody (1A8)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse Ly6G Antibody (1A8) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse Ly6G Antibody (1A8)OthersLy6GNeutrophilInflammationArthritisPeritonitisInhibitorinhibitorinhibit

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