PROTAC BTK Degrader-10

Cat. No.: HY-160966 Purity: 99.24%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

PROTAC BTK Degrader-10 (Example 1P) is a PROTAC degrader for BTK. PROTAC BTK Degrader-10 can be used for research of chronic lymphocytic leukemia (CLL)(Pink: ligand for target protein (HY-170758); Black: linker (HY-W392857); Blue: ligand for E3 ligase Cereblon (HY-W733176))

For research use only. We do not sell to patients.

PROTAC BTK Degrader-10 Chemical Structure

CAS No. : 2988804-46-0

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

Biological Activity
Purity & Documentation
References
Customer Review

Description

PROTAC BTK Degrader-10 (Example 1P) is a PROTAC degrader for BTK. PROTAC BTK Degrader-10 can be used for research of chronic lymphocytic leukemia (CLL)^[1](Pink: ligand for target protein (HY-170758); Black: linker (HY-W392857); Blue: ligand for E3 ligase Cereblon (HY-W733176))

Molecular Weight

771.91

Formula

C₄₂H₄₉N₁₁O₄

CAS No.

2988804-46-0

Appearance

Solid

Color

Light yellow to yellow

SMILES

CC1=C([C@H](NC(C2=NC(C(C)(C)C)=NO2)=O)C)C=CC(C3=NC=NC(NC4=CC=C(C=N4)N5[C@@H](C)CN(CCC6=CC=C(C=C6)N7C(NC(CC7)=O)=O)CC5)=C3)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (129.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2955 mL	6.4774 mL	12.9549 mL
5 mM	0.2591 mL	1.2955 mL	2.5910 mL
10 mM	0.1295 mL	0.6477 mL	1.2955 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.24%

Select Batch:

Data Sheet (264 KB) SDS (251 KB)

COA (244 KB) HNMR (265 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Bian Z, et al., Pyrimidines for degrading bruton's tyrosine kinase. EP4249073

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2955 mL	6.4774 mL	12.9549 mL	32.3872 mL
	5 mM	0.2591 mL	1.2955 mL	2.5910 mL	6.4774 mL
	10 mM	0.1295 mL	0.6477 mL	1.2955 mL	3.2387 mL
	15 mM	0.0864 mL	0.4318 mL	0.8637 mL	2.1591 mL
	20 mM	0.0648 mL	0.3239 mL	0.6477 mL	1.6194 mL
	25 mM	0.0518 mL	0.2591 mL	0.5182 mL	1.2955 mL
	30 mM	0.0432 mL	0.2159 mL	0.4318 mL	1.0796 mL
	40 mM	0.0324 mL	0.1619 mL	0.3239 mL	0.8097 mL
	50 mM	0.0259 mL	0.1295 mL	0.2591 mL	0.6477 mL
	60 mM	0.0216 mL	0.1080 mL	0.2159 mL	0.5398 mL
	80 mM	0.0162 mL	0.0810 mL	0.1619 mL	0.4048 mL
	100 mM	0.0130 mL	0.0648 mL	0.1295 mL	0.3239 mL