2,5-Deoxyfructosazine-¹³C₄  (Synonyms: NSC 270912-¹³C₄)

2,5-Deoxyfructosazine-¹³C₄ (NSC 270912-¹³C₄) is the ¹³C-labeled 2,5-Deoxyfructosazine (HY-135078). 2,5-Deoxyfructosazine is a pyrazine derivative that can be found in cured tobacco and is used as a flavoring agent in the food and tobacco industry. Pyrazines, including 2,5-deoxyfructosazine, can be produced either by pyrolytic decomposition of natural compounds or by the reaction of sugars with alcoholic ammonia. 2,5-Deoxyfructosazine is also formed by the breakdown of D-glucosamine at neutral pH. Like glucosamine, 2,5-deoxyfructosazine has DNA strand breakage activity and strongly inhibits IL-2 production by Jurkat cells stimulated with phytohemagglutinin (IC₅₀=~1.25 mM).

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

308.27

C₈¹³C₄H₂₀N₂O₇

1246815-27-9

17460-13-8

OC[C@@H](O)[C@@H](O)[C@H](O)[13C]1=N[13CH]=[13C](C[C@H](O)[C@H](O)CO)N=[13CH]1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Henry, et al. Synthesis of water-compatible imprinted polymers of in situ produced fructosazine and 2,5-deoxyfructosazine. Talanta 99, 816-823 (2012).