2. PROTAC Anti-infection
  3. PROTACs HIV
  4. FC-14369

FC-14369 is a PROTAC degrader targeting HIV-1 Nef protein with a DC50 value of 160 nM. FC-14369 binds to both Nef and Cereblon E3 ubiquitin ligase via its bifunctional structure, inducing Nef ubiquitination and proteasomal degradation to restore cell-surface CD4 and MHC-I expression and inhibit HIV-1 replication. FC-14369 can be used in research on HIV infection and AIDS. (Pink: Nef ligand-2 (HY-171862); Black: Ethylenediamine (HY-Y0275); Blue: Thalidomide (HY-14658))

For research use only. We do not sell to patients.

FC-14369

FC-14369 Chemical Structure

CAS No. : 3066894-28-5

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Customer Review

Based on 1 publication(s) in Google Scholar

FC-14369 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All HIV Isoform Specific Products:

View All Isoforms
HIV HIV-1 HIV-2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

FC-14369 is a PROTAC degrader targeting HIV-1 Nef protein with a DC50 value of 160 nM. FC-14369 binds to both Nef and Cereblon E3 ubiquitin ligase via its bifunctional structure, inducing Nef ubiquitination and proteasomal degradation to restore cell-surface CD4 and MHC-I expression and inhibit HIV-1 replication. FC-14369 can be used in research on HIV infection and AIDS[1]. (Pink: Nef ligand-2 (HY-171862); Black: Ethylenediamine (HY-Y0275); Blue: Thalidomide (HY-14658))

IC50 & Target

HIV-1

 

Molecular Weight

855.22

Formula

C42H34ClF3N8O7
CAS No.
Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCCNC(COC4=CC=C(CCC5=C(O)N(C6=NC7=C(N6)C=CC(Cl)=C7)N=C5C8=CC=C(C(F)(F)F)C=C8)C=C4)=O)=CC=C3)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (116.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1693 mL 5.8464 mL 11.6929 mL
5 mM 0.2339 mL 1.1693 mL 2.3386 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 97.85%

SDS (252 KB)

COA (249 KB) HNMR (222 KB) RP-HPLC (227 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1693 mL 5.8464 mL 11.6929 mL 29.2322 mL
5 mM 0.2339 mL 1.1693 mL 2.3386 mL 5.8464 mL
10 mM 0.1169 mL 0.5846 mL 1.1693 mL 2.9232 mL
15 mM 0.0780 mL 0.3898 mL 0.7795 mL 1.9488 mL
20 mM 0.0585 mL 0.2923 mL 0.5846 mL 1.4616 mL
25 mM 0.0468 mL 0.2339 mL 0.4677 mL 1.1693 mL
30 mM 0.0390 mL 0.1949 mL 0.3898 mL 0.9744 mL
40 mM 0.0292 mL 0.1462 mL 0.2923 mL 0.7308 mL
50 mM 0.0234 mL 0.1169 mL 0.2339 mL 0.5846 mL
60 mM 0.0195 mL 0.0974 mL 0.1949 mL 0.4872 mL
80 mM 0.0146 mL 0.0731 mL 0.1462 mL 0.3654 mL
100 mM 0.0117 mL 0.0585 mL 0.1169 mL 0.2923 mL
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FC-14369 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FC-143693066894-28-5FC14369FC 14369PROTACsHIVHuman immunodeficiency virusPROTACHIV-1 Nef proteinHIV infectionAIDSInhibitorinhibitorinhibit

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