2. PROTAC Cell Cycle/DNA Damage
  3. PROTACs CDK
  4. CPD-39

CPD-39 is a potent and orally active CCND1 and CDK4 heterobifunctional PROTAC degrader. CPD-39 shows anti-proliferation. (Pink: ligand for target protein (HY-50767); black: linker (HY-20240); Blue: E3 ligase ligand (HY-168667)).

For research use only. We do not sell to patients.

CPD-39 Chemical Structure

CPD-39 Chemical Structure

CAS No. : 3055472-38-0

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Based on 1 publication(s) in Google Scholar

CPD-39 Related Antibodies

Top Publications Citing Use of Products

View All PROTACs Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

View All CDK Isoform Specific Products:

View All Isoforms
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

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Description

CPD-39 is a potent and orally active CCND1 and CDK4 heterobifunctional PROTAC degrader. CPD-39 shows anti-proliferation. (Pink: ligand for target protein (HY-50767); black: linker (HY-20240); Blue: E3 ligase ligand (HY-168667))[1].

IC50 & Target[1].

CDK4

 

CCND1

 

Molecular Weight

884.04

Formula

C46H57N15O4
CAS No.
Appearance

Solid

Color

Colorless to light yellow

SMILES

CC(C1=C(C2=C(N(C1=O)C3CCCC3)N=C(N=C2)NC4=CC=C(C=N4)N5CCN(CC5)CC(NC6CC7(CC(C7)NC8=NC(NC)=CC=C8C(NC9=NN=C(C=C9)N(C)C)=O)C6)=O)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (113.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1312 mL 5.6559 mL 11.3117 mL
5 mM 0.2262 mL 1.1312 mL 2.2623 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1312 mL 5.6559 mL 11.3117 mL 28.2793 mL
5 mM 0.2262 mL 1.1312 mL 2.2623 mL 5.6559 mL
10 mM 0.1131 mL 0.5656 mL 1.1312 mL 2.8279 mL
15 mM 0.0754 mL 0.3771 mL 0.7541 mL 1.8853 mL
20 mM 0.0566 mL 0.2828 mL 0.5656 mL 1.4140 mL
25 mM 0.0452 mL 0.2262 mL 0.4525 mL 1.1312 mL
30 mM 0.0377 mL 0.1885 mL 0.3771 mL 0.9426 mL
40 mM 0.0283 mL 0.1414 mL 0.2828 mL 0.7070 mL
50 mM 0.0226 mL 0.1131 mL 0.2262 mL 0.5656 mL
60 mM 0.0189 mL 0.0943 mL 0.1885 mL 0.4713 mL
80 mM 0.0141 mL 0.0707 mL 0.1414 mL 0.3535 mL
100 mM 0.0113 mL 0.0566 mL 0.1131 mL 0.2828 mL
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CPD-39 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CPD-393055472-38-0CPD39CPD 39PROTACsCDKCyclin dependent kinaseT47D cellsCalu -1 cellsMCF7 cellsorally activeanti-proliferationInhibitorinhibitorinhibit

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