E-cadherin Antibody (YA4821)

E-cadherin Antibody (YA4821) is a mouse-derived and non-conjugated monoclonal antibody, targeting to E-cadherin. It can be applicated for WB, IHC-P, ICC/IF, FC, ELISA assays, in the background of human, mouse, monkey.

Cadherins are calcium-dependent cell adhesion proteins that preferentially interact homophilically between connected cells, contributing to the sorting of heterogeneous cell types. CDH1 regulates epithelial cell-cell adhesion, mobility, and proliferation. By interacting with AMOTL2 (by similar), it organizes radial actin fiber structures and mediates cellular responses to contractile forces by anchoring these fibers to CDH1 junction complexes at the membrane. During early desmosome formation, CDH1 facilitates recruitment of DSG2 and DSP to desmosomal plaques. It acts as a potent invasion suppressor and serves as a ligand for integrin α-E/β-7. E-Cad/CTF2 promotes non-amyloidogenic processing of Aβ precursors and strongly inhibits APP C99/C83 production. Additionally (Microbial infection), CDH1 functions as a receptor for Listeria monocytogenes via binding of bacterial InlA to mediate internalization.

P12830

Observed band size: 125-130 kDa

affinity purified.

Non-conjugated

Unmodified

Primary Antibody; Mouse Monoclonal Antibody

Monoclonal

Mouse

Human, Mouse, Monkey

WB: 1:500-1:2000; IHC: 1:200-1:1000; FC: 1:200-1:400; ELISA: 1:10000; ICC/IF: 1:50-200

WB, IHC-P, ICC/IF, FC, ELISA

Liquid

Supplied in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

Purified recombinant fragment of human E-cadherin expressed in E. Coli.