2. PROTAC Protein Tyrosine Kinase/RTK
  3. Btk PROTACs
  4. L18I

L18I is a PROTAC targeting Btk that can reduce inflammation in autoimmune diseases such as lupus erythematosus induced by BM12 splenocytes. L18I is composed of PROTAC target protein ligand IBT6A (HY-13036A) (red part), PROTAC Linker Propargyl-PEG3-alcohol (HY-41921) (balck part) and E3 ubiquitin ligase ligand Lenalidomide-Br (HY-43722) (blue part), of which the active control of the target protein ligand is IBT6A-CO-ethyne (HY-163963), and the conjugate of E3 ubiquitin ligase ligand + Linker is Lenalidomide-C3-PEG3-N3 (HY-163964)[1].

For research use only. We do not sell to patients.

L18I Chemical Structure

L18I Chemical Structure

CAS No. : 2451070-32-7

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Based on 1 publication(s) in Google Scholar

L18I Related Antibodies

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View All PROTACs Isoform Specific Products:

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

L18I is a PROTAC targeting Btk that can reduce inflammation in autoimmune diseases such as lupus erythematosus induced by BM12 splenocytes. L18I is composed of PROTAC target protein ligand IBT6A (HY-13036A) (red part), PROTAC Linker Propargyl-PEG3-alcohol (HY-41921) (balck part) and E3 ubiquitin ligase ligand Lenalidomide-Br (HY-43722) (blue part), of which the active control of the target protein ligand is IBT6A-CO-ethyne (HY-163963), and the conjugate of E3 ubiquitin ligase ligand + Linker is Lenalidomide-C3-PEG3-N3 (HY-163964)[1].

IC50 & Target

Btk[1]
Molecular Weight

897.98

Formula

C47H51N11O8
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C1C2=CC=CC(CCCOCCOCCOCCN3C=C(C(N4CCC[C@@H](N5N=C(C6=CC=C(OC7=CC=CC=C7)C=C6)C8=C5N=CN=C8N)C4)=O)N=N3)=C2CN1C9C(NC(CC9)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (111.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1136 mL 5.5681 mL 11.1361 mL
5 mM 0.2227 mL 1.1136 mL 2.2272 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1136 mL 5.5681 mL 11.1361 mL 27.8403 mL
5 mM 0.2227 mL 1.1136 mL 2.2272 mL 5.5681 mL
10 mM 0.1114 mL 0.5568 mL 1.1136 mL 2.7840 mL
15 mM 0.0742 mL 0.3712 mL 0.7424 mL 1.8560 mL
20 mM 0.0557 mL 0.2784 mL 0.5568 mL 1.3920 mL
25 mM 0.0445 mL 0.2227 mL 0.4454 mL 1.1136 mL
30 mM 0.0371 mL 0.1856 mL 0.3712 mL 0.9280 mL
40 mM 0.0278 mL 0.1392 mL 0.2784 mL 0.6960 mL
50 mM 0.0223 mL 0.1114 mL 0.2227 mL 0.5568 mL
60 mM 0.0186 mL 0.0928 mL 0.1856 mL 0.4640 mL
80 mM 0.0139 mL 0.0696 mL 0.1392 mL 0.3480 mL
100 mM 0.0111 mL 0.0557 mL 0.1114 mL 0.2784 mL
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L18I Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L18I2451070-32-7BtkPROTACsBruton tyrosine kinaseInhibitorinhibitorinhibit

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