PI4P5K

Phosphatidylinositol 4-phosphate 5-kinases

Phosphatidylinositol 4-phosphate 5-kinases (PI4P5K) are a class of enzymes that phosphorylate phosphatidylinositol 4-phosphate. Phosphatidylinositol 4-phosphate 5-kinases phosphorylate phosphatidylinositol 4-phosphate (PI4P) in the 5-position to form phosphatidylinositol 4,5-bisphosphate (PI45P2). There are two types of phosphatidylinositol 4-phosphate 5-kinases found which includes Type I and Type II. Murine PI4P5K type Ibeta (mPIP5K-Ibeta) was implicated in receptor mediated endocytosis through the isolation of a truncated and inactive form of the enzyme that blocked the ligand-dependent downregulation of the colony-stimulating factor-1 receptor. Phosphatidylinositol 4-phosphate 5-kinases regulate diverse cellular processes such as G protein-coupled receptor(GPCR) signaling, vesicle trafficking, chemotaxis and cellular movement^[1]^[2].

References:

[1]. Jones DH, et al. Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the golgi compartment. J Biol Chem. 2000 May 5;275(18):13962-6. [Content Brief]

[2]. Galiano FJ, et al. Overexpression of murine phosphatidylinositol 4-phosphate 5-kinase type Ibeta disrupts a phosphatidylinositol 4,5 bisphosphate regulated endosomal pathway. J Cell Biochem. 2002;85(1):131-45. [Content Brief]

PI4P5K Inhibitors (5)

PI4P5K Related Products (6):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-16937

ISA-2011B	Inhibitor	99.85%
ISA-2011B is a PIP5K1α inhibitor with promising anticancer effects .

HY-110150

UNC3230	Inhibitor	99.39%
UNC3230 is a potent, selective and ATP-competitive PIP5K1C inhibitor with an IC₅₀ of ~41 nM. UNC3230 also inhibits PIP4K2C and does not inhibit any of the other lipid kinases that regulate phosphoinositide levels. UNC3230 has antinociceptive and anticancer effects.

HY-163476

PIP5K1C-IN-1	Inhibitor	98.71%
PIP5K1C-IN-1 (Compound 30) is a potent PIP5K1C inhibitor, with an IC₅₀ of 0.80 nM. PIP5K1C-IN-1 exhibits low total clearance in mice and high levels of kinase selectivity. PIP5K1C-IN-1 can be used for the research of cancer and chronic pain.

HY-163572

PIP5K1α-IN-1	Inhibitor	99.81%
PIP5K1α-IN-1 (Compound 3e) is an inhibitor for phosphatidylinositol 4-phosphate 5-kinase type I α (PIP5K1α) with an IC₅₀ of 0.46 μM.

HY-E70633

PIP5K1C Recombinant Human Active Lipid Kinase
PIP5K1C Recombinant Human Active Lipid Kinase is a phosphatidylinositol 4-phosphate 5-kinase (PIP5K) with nociceptive sensitization. PIP5K1C Recombinant Human Active Lipid Kinase can be used to study the role of PIP5K1C in nociceptive signaling and sensitization.

HY-163477

PIP5K1C-IN-2	Inhibitor
PIP5K1C-IN-2 (compound 33) is a potent and selective 4-phosphate 5-kinases 1 C (PIP5K1C) inhibitor with an IC₅₀ value of 0.0059 µM.

Name
Email *

	Sorry, but the email address you supplied was invalid.