Neurofilament light polypeptide/NEFL, Human (His)

Neurofilament light chain polypeptide (NEFL), like NEFM and NEFH, is an important component of neurofilaments and maintains neuronal caliber. NEFL interacts cooperatively with PRPH and INA to facilitate the assembly of neuronal filamentous networks. Neurofilament light polypeptide/NEFL, Human (His) is the recombinant human-derived Neurofilament light polypeptide/NEFL, Human (His) protein, expressed by E. coli, with C-His labeled tag.

Neurofilament light polypeptide (NEFL) is a crucial component of neurofilaments, typically comprising a triad of intermediate filament proteins—NEFL, NEFM, and NEFH—that collectively contribute to the maintenance of neuronal caliber. NEFL may also engage in cooperative interactions with other neuronal intermediate filament proteins such as PRPH and INA, participating in the intricate assembly of neuronal filamentous networks. In addition to forming homodimers, NEFL forms heterodimers with NEFH or NEFM, and these complexes can further hetero-oligomerize. Furthermore, NEFL establishes interactions with specific proteins, including ARHGEF28 and TRIM2, highlighting its involvement in molecular networks that regulate various aspects of neuronal structure and function.

Human

E. coli

C-His

P07196 (S2-D543)

4747

Approximately 65-80 kDa, based on SDS-PAGE under reducing conditions.

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.