2. PROTAC Immunology/Inflammation
  3. PROTACs IRAK Toll-like Receptor (TLR) Interleukin Related
  4. PROTAC IRAK4 degrader-13

PROTAC IRAK4 degrader-13 (Degrader 1) is a selective IRAK4 PROTAC degrader with DC50s of 0.86 and 1.1 nM for monocytes and lymphocytes in PBMCs, respectively. PROTAC IRAK4 degrader-13 significantly induces TIR signal activation, and inhibits the expression of circulating proinflammatory cytokines in Imiquimod (HY-B0180) induced psoriasis mice model. PROTAC IRAK4 degrader-13 can be used for TLR- and IL-1R-driven driven neutrophilic inflammation diseases like hidradenitis suppurativa (HS) and atopic dermatitis (AD) research. Pink: IRAK4 ligand; Blue: E3 ligase ligand; Black: linker

For research use only. We do not sell to patients.

PROTAC IRAK4 degrader-13 Chemical Structure

PROTAC IRAK4 degrader-13 Chemical Structure

CAS No. : 2432992-21-5

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PROTAC IRAK4 degrader-13 Related Antibodies

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Description

PROTAC IRAK4 degrader-13 (Degrader 1) is a selective IRAK4 PROTAC degrader with DC50s of 0.86 and 1.1 nM for monocytes and lymphocytes in PBMCs, respectively. PROTAC IRAK4 degrader-13 significantly induces TIR signal activation, and inhibits the expression of circulating proinflammatory cytokines in Imiquimod (HY-B0180) induced psoriasis mice model. PROTAC IRAK4 degrader-13 can be used for TLR- and IL-1R-driven driven neutrophilic inflammation diseases like hidradenitis suppurativa (HS) and atopic dermatitis (AD) research[1]. Pink: IRAK4 ligand; Blue: E3 ligase ligand; Black: linker

IC50 & Target[1]

IRAK4

 

IL-6

 

IL-8

 

IL-17

 

IL-22

 

IL-23

 

IL-1b

 

Molecular Weight

843.94

Formula

C44H52F3N9O5
CAS No.
SMILES

O=C(C1=NC(C(F)(F)F)=CC=C1)NC2=CC3=CN([C@H]4CC[C@H](CN(C5CCN(CC6=C(C(N7C(CC8)C(NC8=O)=O)=CC=C6)N(C)C7=O)CC5)C)CC4)N=C3C=C2C(C)(O)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC IRAK4 degrader-13 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC IRAK4 degrader-132432992-21-5PROTACsIRAKToll-like Receptor (TLR)Interleukin RelatedInterleukin-1 receptor associated kinaseIL-1R associated kinaseILPROTACDegradationIRAK4TIR signalPBMCPsoriasis mice modelNeutrophilic inflammation diseasesHidradenitis suppurativaHSAtopic dermatitisADInhibitorinhibitorinhibit

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