2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Topoisomerase I inhibitor 16

Topoisomerase I inhibitor 21 (Compound 3e) is an inhibitor for Topoisomerase I through stabilization of enzyme-DNA complex. Topoisomerase I inhibitor 21 exhibits antiproliferative activity in 39 human cancer cells (JFCR39) with mean GI50 39 nM.

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Topoisomerase I inhibitor 16

Topoisomerase I inhibitor 16 Chemical Structure

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Topoisomerase I inhibitor 16 Related Antibodies

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Description

Topoisomerase I inhibitor 21 (Compound 3e) is an inhibitor for Topoisomerase I through stabilization of enzyme-DNA complex. Topoisomerase I inhibitor 21 exhibits antiproliferative activity in 39 human cancer cells (JFCR39) with mean GI50 39 nM[1].

IC50 & Target

Topoisomerase I

 

Cellular Effect
Cell Line Type Value Description References
A549 GI50
49 nM
Compound: 3e
Growth inhibition of human A549 cells assessed as reduction in cell viability
Growth inhibition of human A549 cells assessed as reduction in cell viability
[PMID: 38518997]
ACHN GI50
< 10 nM
Compound: 3e
Growth inhibition of human ACHN cells assessed as reduction in cell viability
Growth inhibition of human ACHN cells assessed as reduction in cell viability
[PMID: 38518997]
DU-145 GI50
< 10 nM
Compound: 3e
Growth inhibition of human DU-145 cells assessed as reduction in cell viability
Growth inhibition of human DU-145 cells assessed as reduction in cell viability
[PMID: 38518997]
HCT-116 GI50
< 10 nM
Compound: 3e
Growth inhibition of human HCT-116 cells assessed as reduction in cell viability
Growth inhibition of human HCT-116 cells assessed as reduction in cell viability
[PMID: 38518997]
LOX IMVI GI50
< 10 nM
Compound: 3e
Growth inhibition of human LOX IMVI cells assessed as reduction in cell viability
Growth inhibition of human LOX IMVI cells assessed as reduction in cell viability
[PMID: 38518997]
MCF7 GI50
< 10 nM
Compound: 3e
Growth inhibition of human MCF7 cells assessed as reduction in cell viability
Growth inhibition of human MCF7 cells assessed as reduction in cell viability
[PMID: 38518997]
MKN-28 GI50
19 nM
Compound: 3e
Growth inhibition of human MKN-28 cells assessed as reduction in cell viability
Growth inhibition of human MKN-28 cells assessed as reduction in cell viability
[PMID: 38518997]
SK-OV-3 GI50
18 nM
Compound: 3e
Growth inhibition of human SK-OV-3 cells assessed as reduction in cell viability
Growth inhibition of human SK-OV-3 cells assessed as reduction in cell viability
[PMID: 38518997]
U-251 GI50
< 10 nM
Compound: 3e
Growth inhibition of human U-251 cells assessed as reduction in cell viability
Growth inhibition of human U-251 cells assessed as reduction in cell viability
[PMID: 38518997]
In Vitro

Topoisomerase I inhibitor 21 inhibits proliferations of cancer cells MCF7, U251, HCT-166, A549, LOX-IMVI, SK-OV-3, ACHN, MKN28 and DU145, with EC50s <50 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Topoisomerase I inhibitor 16 Related Antibodies
Molecular Weight

457.52

Formula

C27H27N3O4
SMILES

OC1=CC2=C(C=C1)C3=C(C(N=CC4=C5C=C(OC)C(O)=C4)=C5N3CCCN6CCOCC6)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Topoisomerase I inhibitor 16 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topoisomerase I inhibitor 16Topoisomerase I inhibitor16Topoisomerase I inhibitor-16TopoisomeraseJFCR39MCF7U251HCT-166A549LOX-IMVISK-OV-3ACHNMKN28DU145Inhibitorinhibitorinhibit

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