2. Others Metabolic Enzyme/Protease Autophagy Membrane Transporter/Ion Channel
  3. Isotope-Labeled Compounds HMG-CoA Reductase (HMGCR) Autophagy Potassium Channel
  4. Rosuvastatin-d3

Rosuvastatin-d3 is a deuterium labeled Rosuvastatin. Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals.

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Rosuvastatin-d<sub>3</sub> Chemical Structure

Rosuvastatin-d3 Chemical Structure

CAS No. : 1133429-16-9

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Other Forms of Rosuvastatin-d3:

Rosuvastatin-d3 Related Antibodies

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Description

Rosuvastatin-d3 is a deuterium labeled Rosuvastatin. Rosuvastatin (ZD 4522) is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM[1]. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM, delayed cardiac repolarization, and thereby prolonged action potential durations (APDs) and corrected QT interval (QTc) intervals[2].

Molecular Weight

484.56

Synonyms

ZD 4522 d3

Formula

C22H25D3FN3O6S
CAS No.
Unlabeled CAS
SMILES

FC(C=C1)=CC=C1C2=NC(N(C([2H])([2H])[2H])S(=O)(C)=O)=NC(C(C)C)=C2/C=C/[C@@H](O)C[C@@H](O)CC(O)=O
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Rosuvastatin-d3 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rosuvastatin-d31133429-16-9ZD 4522 d3Isotope-Labeled CompoundsHMG-CoA Reductase (HMGCR)AutophagyPotassium ChannelKcsAether-a-go-gorelatedgenehERGcardiacrepolarizationactionpotentialdurationsAPDsQTQTcHsp70low-densitylipoproteincholesteroltriglyceridesInhibitorinhibitorinhibit

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