CD314/NKG2D Antibody (YA3918)

CD314/NKG2D Antibody (YA3918) is a mouse-derived and non-conjugated IgG2a antibody, targeting to CD314. It can be applicated for WB, FC, ELISA assays, in the background of human, rat.

CD314 functions as an activating and costimulatory receptor involved in immunosurveillance by binding to various cellular stress-inducible ligands displayed on the surface of autologous tumor cells and virus-infected cells. It delivers both stimulatory and costimulatory innate immune responses in activated killer (NK) cells, leading to cytotoxic activity. As a costimulatory receptor for the T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses, it amplifies T-cell activation. CD314 stimulates perforin-mediated elimination of ligand-expressing tumor cells, with signaling involving calcium influx and culminating in TNF-alpha expression. It participates in NK cell-mediated bone marrow graft rejection and may regulate NK cell differentiation and survival. Its ligands include members of MHC class I-related glycoprotein subfamilies such as MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2 > ULBP1 > ULBP3), and ULBP4.

P26718 

Predicted band size: 25 kDa; Observed band size: 25 kDa

affinity purified.

Non-conjugated

Primary Antibody; Mouse Monoclonal Antibody

Mouse

Human, Rat

WB: 1/500-1/2000; FC: 1/200-1/400; ELISA: 1/10000

WB, FC, ELISA

Liquid

Supplied in PBS with 0.05% sodium azide

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG2a

Purified recombinant fragment of human CD314 (AA: extra 73-216) expressed in E. Coli.