2. Anti-infection Immunology/Inflammation
  3. SARS-CoV COX
  4. SARS-CoV-2 Mpro-IN-41

SARS-CoV-2 Mpro-IN-41 (Compound 7e) is an orally active inhibitor of COX-2 and SARS-CoV-2 M pro (IC50 values are 9.66 μM and 13.24 μM, respectively). SARS-CoV-2 Mpro-IN-41 also has a certain inhibitory activity against COX-1 (IC50: 46.11 μM). SARS-CoV-2 Mpro-IN-41 can significantly inhibit the expression of inflammatory-related cytokines (such as TNF-α, IL-6, IL-1β) and exert anti-inflammatory effects. SARS-CoV-2 Mpro-IN-41 exerts anti-inflammatory and antiviral effects by selectively inhibiting COX-2 and SARS-CoV-2 M pro. SARS-CoV-2 Mpro-IN-41 can be used for anti-inflammatory and anti-coronavirus research.

For research use only. We do not sell to patients.

SARS-CoV-2 Mpro-IN-41 Chemical Structure

SARS-CoV-2 Mpro-IN-41 Chemical Structure

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SARS-CoV-2 Mpro-IN-41 Related Antibodies

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Description

SARS-CoV-2 Mpro-IN-41 (Compound 7e) is an orally active inhibitor of COX-2 and SARS-CoV-2 M pro (IC50 values are 9.66 μM and 13.24 μM, respectively). SARS-CoV-2 Mpro-IN-41 also has a certain inhibitory activity against COX-1 (IC50: 46.11 μM). SARS-CoV-2 Mpro-IN-41 can significantly inhibit the expression of inflammatory-related cytokines (such as TNF-α, IL-6, IL-1β) and exert anti-inflammatory effects. SARS-CoV-2 Mpro-IN-41 exerts anti-inflammatory and antiviral effects by selectively inhibiting COX-2 and SARS-CoV-2 M pro. SARS-CoV-2 Mpro-IN-41 can be used for anti-inflammatory and anti-coronavirus research[1].

IC50 & Target[1]

COX-1

46.11 μM (IC50)

COX-2

9.66 μM (IC50)

Molecular Weight

519.01

Formula

C27H23ClN4O3S
SMILES

O=C(C(C1=NN(C2=CC=C(S(=O)(C)=O)C=C2)C(C3=CC=C(Cl)C=C3)=C1)=C(C)N4C)N4C5=CC=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SARS-CoV-2 Mpro-IN-41 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SARS-CoV-2 Mpro-IN-41SARS-CoVCOXSARS coronavirusCyclooxygenaseCOX-2NSAIDCOVID-19ARDSWistar albino ratInhibitorinhibitorinhibit

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