Tubulin polymerization-IN-79

Cat. No.: HY-176171: Data Sheet Handling Instructions
FAQs
Technical Support

Tubulin polymerization-IN-79 (Compound C20) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-79 shows potent antiproliferative activity against esophageal cancer cells (e.g., KYSE450, IC₅₀=0.36 μM; EC-109, IC₅₀=0.63 μM). Tubulin polymerization-IN-79 occupies the colchicine binding site to disrupt microtubule network integrity, activating the Hippo signaling pathway, downregulating the oncogenic protein YAP expression, and inducing G2/M phase arrest and apoptosis in esophageal cancer cells. Tubulin polymerization-IN-79 is promising for research of esophageal cancers.

For research use only. We do not sell to patients.

Tubulin polymerization-IN-79 Chemical Structure

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All YAP Isoform Specific Products:

View All Isoforms

YAP/TAZ YAP/TAZ-TEAD TEAD YAP1

Biological Activity
Purity & Documentation
References
Customer Review

Description	Tubulin polymerization-IN-79 (Compound C20) is a tubulin polymerization inhibitor. Tubulin polymerization-IN-79 shows potent antiproliferative activity against esophageal cancer cells (e.g., KYSE450, IC₅₀=0.36 μM; EC-109, IC₅₀=0.63 μM). Tubulin polymerization-IN-79 occupies the colchicine binding site to disrupt microtubule network integrity, activating the Hippo signaling pathway, downregulating the oncogenic protein YAP expression, and inducing G2/M phase arrest and apoptosis in esophageal cancer cells. Tubulin polymerization-IN-79 is promising for research of esophageal cancers^[1].
Molecular Weight	385.39
Formula	C₁₉H₁₅NO₆S
SMILES	O=C1C=C(C2=CC=CC=C2O1)OS(=O)(C3=CC=C(C=C3)N4CCCC4=O)=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (272 KB) Handling Instructions (2659 KB)
References	[1]. Zhao D, et al. Discovery of novel coumarin-sulfonates as tubulin polymerization inhibitors targeting the colchicine-binding site with potent anticancer activities. Bioorg Med Chem Lett. 2025 Sep 1;125-126:130284.