2. Cell Cycle/DNA Damage Stem Cell/Wnt
  3. Casein Kinase
  4. JNJ-6204

JNJ-6204 is a dual inhibitor for CSNK1D (Casein Kinase 1 Delta) and CSNK1E (Casein Kinase 1 Epsilon) (CSNK1D IC50=2.3 nM; CSNK1E IC50=137 nM). JNJ-6204 shows good brain exposure.

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JNJ-6204 Chemical Structure

JNJ-6204 Chemical Structure

CAS No. : 2765264-50-2

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JNJ-6204 Related Antibodies

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Description

JNJ-6204 is a dual inhibitor for CSNK1D (Casein Kinase 1 Delta) and CSNK1E (Casein Kinase 1 Epsilon) (CSNK1D IC50=2.3 nM; CSNK1E IC50=137 nM). JNJ-6204 shows good brain exposure[1][2].

IC50 & Target

IC50: 2.3 nM (CSNK1D)[2]
In Vitro

JNJ-6204 inhibits CSNK1D in the BRET whole cell binding assay and in the PER2 translocation whole cell functional assay with IC50s of 72 nM and 542 nM, respectively[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JNJ-6204 Related Antibodies
Molecular Weight

370.41

Formula

C19H11D6FN6O
CAS No.
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

FC1=CC=C(N=C1)C2=NN3C(COC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C3)=C2C4=C5C(NN=C5)=NC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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JNJ-6204 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-62042765264-50-2JNJ6204JNJ 6204Casein Kinasegood brain exposureInhibitorinhibitorinhibit

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