2. MAPK/ERK Pathway
  3. Raf
  4. Vem-L-Cy5

Vem-L-Cy5 (compound 3)，modified with the NIR fluorophore cyanine-5 (Cy5)，is a Vemurafenib (HY-12057)-based inhibitor of BRAF. Vem-L-Cy5 targets to BRAFV600E，and also inhibits MEK phosphorylation. Vem-L-Cy5 has cell permeability，and inhibits cell growth of many types of cancer.

For research use only. We do not sell to patients.

Vem-L-Cy5

Vem-L-Cy5 Chemical Structure

CAS No. : 3057544-65-4

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Based on 1 publication(s) in Google Scholar

Vem-L-Cy5 Related Antibodies

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Description

Vem-L-Cy5 (compound 3)，modified with the NIR fluorophore cyanine-5 (Cy5)，is a Vemurafenib (HY-12057)-based inhibitor of BRAF. Vem-L-Cy5 targets to BRAFV600E，and also inhibits MEK phosphorylation. Vem-L-Cy5 has cell permeability，and inhibits cell growth of many types of cancer[1].

Molecular Weight

1194.31

Formula

C63H68F5N7O9S
CAS No.
Appearance

Solid

Color

Light blue to blue

SMILES

CC1(C)C(/C=C/C=C/C=C2N(CCCCCC(NCCOCCOCC(NC3=CC=C(C4=CN=C(NC=C5C(C6=C(F)C=CC(NS(=O)(CCC)=O)=C6F)=O)C5=C4)C=C3)=O)=O)C7=C(C=CC=C7)C/2(C)C)=[N+](C)C8=C1C=CC=C8.O=C([O-])C(F)(F)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (41.87 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8373 mL 4.1865 mL 8.3730 mL
5 mM 0.1675 mL 0.8373 mL 1.6746 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8373 mL 4.1865 mL 8.3730 mL 20.9326 mL
5 mM 0.1675 mL 0.8373 mL 1.6746 mL 4.1865 mL
10 mM 0.0837 mL 0.4187 mL 0.8373 mL 2.0933 mL
15 mM 0.0558 mL 0.2791 mL 0.5582 mL 1.3955 mL
20 mM 0.0419 mL 0.2093 mL 0.4187 mL 1.0466 mL
25 mM 0.0335 mL 0.1675 mL 0.3349 mL 0.8373 mL
30 mM 0.0279 mL 0.1396 mL 0.2791 mL 0.6978 mL
40 mM 0.0209 mL 0.1047 mL 0.2093 mL 0.5233 mL
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Vem-L-Cy5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vem-L-Cy53057544-65-4RafRaf kinaseshairy cell leukemiaanaplastic thyroid cancercolorectal cancer and melanomaInhibitorinhibitorinhibit

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